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2J6W
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BU of 2j6w by Molmil
R164N mutant of the RUNX1 Runt domain
分子名称: CHLORIDE ION, RUNT-RELATED TRANSCRIPTION FACTOR 1
著者Grembecka, J, Zhe, L, Lukasik, S.M, Liu, Y, Bielnicka, I, Bushweller, J.H, Speck, N.A.
登録日2006-10-04
公開日2007-10-09
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A Mutation in the S-Switch Region of the Runt Domain Alters the Dynamics of an Allosteric Network Responsible for Cbfbeta Regulation.
J.Mol.Biol., 364, 2006
2JYI
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BU of 2jyi by Molmil
Solution structure of MLL CXXC domain
分子名称: ZINC ION, Zinc finger protein HRX
著者Cierpicki, T, Bushweller, J.H.
登録日2007-12-13
公開日2008-12-09
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Structural basis for maintenance of unmethylated CpG elements by the CXXC domain of MLL and its critical contributions to MLL-AF9 immortalization activity
To be Published
2K73
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BU of 2k73 by Molmil
Solution NMR structure of integral membrane protein DsbB
分子名称: Disulfide bond formation protein B
著者Zhou, Y, Cierpicki, T, Flores Jimenez, R.H, Lukasik, S.M, Ellena, J.F, Cafiso, D.S, Kadokura, H, Beckwith, J, Bushweller, J.H.
登録日2008-08-01
公開日2008-10-07
最終更新日2021-10-20
実験手法SOLUTION NMR
主引用文献NMR solution structure of the integral membrane enzyme DsbB: functional insights into DsbB-catalyzed disulfide bond formation.
Mol.Cell, 31, 2008
2KNH
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BU of 2knh by Molmil
The Solution structure of the eTAFH domain of AML1-ETO complexed with HEB peptide
分子名称: Protein CBFA2T1, Transcription factor 12
著者Park, S, Cierpicki, T, Tonelli, M, Bushweller, J.H.
登録日2009-08-25
公開日2009-10-06
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity.
Blood, 113, 2009
2KKF
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BU of 2kkf by Molmil
Solution structure of MLL CXXC domain in complex with palindromic CPG DNA
分子名称: 5'-D(*CP*CP*CP*TP*GP*CP*GP*CP*AP*GP*GP*G)-3', Histone-lysine N-methyltransferase HRX, ZINC ION
著者Cierpicki, T, Riesbeck, J.E, Grembecka, J.E, Lukasik, S.M, Popovic, R, Omonkowska, M, Shultis, D.S, Zeleznik-Le, N.J, Bushweller, J.H.
登録日2009-06-18
公開日2009-12-08
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia.
Nat.Struct.Mol.Biol., 17, 2010
2K74
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BU of 2k74 by Molmil
Solution NMR structure of DsbB-ubiquinone complex
分子名称: Disulfide bond formation protein B, UBIQUINONE-2
著者Zhou, Y, Cierpicki, T, Flores Jimenez, R.H, Lukasik, S.M, Ellena, J.F, Cafiso, D.S, Kadokura, H, Beckwith, J, Bushweller, J.H.
登録日2008-08-01
公開日2008-10-07
最終更新日2021-10-20
実験手法SOLUTION NMR
主引用文献NMR solution structure of the integral membrane enzyme DsbB: functional insights into DsbB-catalyzed disulfide bond formation.
Mol.Cell, 31, 2008
2KYX
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BU of 2kyx by Molmil
Solution structure of the RRM domain of CYP33
分子名称: Peptidyl-prolyl cis-trans isomerase E
著者Park, S, Bushweller, J.H.
登録日2010-06-09
公開日2010-08-25
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献The PHD3 domain of MLL acts as a CYP33-regulated switch between MLL-mediated activation and repression .
Biochemistry, 49, 2010
2N4Q
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BU of 2n4q by Molmil
Solution NMR structure of CBX8 in complex with AF9 (CBX8-AF9)
分子名称: Chromobox protein homolog 8, Protein AF-9
著者Kuntimaddi, A, Leach, B.I, Bushweller, J.H.
登録日2015-06-30
公開日2016-07-20
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Solution NMR Structure of CBX8 in complex with AF9 (CBX8-AF9)
To be Published
2MV7
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BU of 2mv7 by Molmil
Solution NMR structure of DOT1L in complex with AF9 (DOT1L-AF9)
分子名称: Histone-lysine N-methyltransferase, H3 lysine-79 specific, Protein AF-9
著者Kuntimaddi, A, Bushweller, J.H.
登録日2014-09-24
公開日2015-04-22
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Degree of Recruitment of DOT1L to MLL-AF9 Defines Level of H3K79 Di- and Tri-methylation on Target Genes and Transformation Potential.
Cell Rep, 11, 2015
2ODD
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BU of 2odd by Molmil
Solution structure of the MYND domain from AML1-ETO complexed with SMRT, a corepressor
分子名称: Protein CBFA2T1, SMRT, ZINC ION
著者Liu, Y.Z, Chen, W, Gaudet, J, Cheney, M.D, Roudaia, L, Cierpicki, T, Klet, R.C, Hartman, K, Laue, T.M, Speck, N.A, Bushweller, J.H.
登録日2006-12-22
公開日2007-06-19
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity.
Cancer Cell, 11, 2007
2OD1
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BU of 2od1 by Molmil
Solution structure of the MYND domain from human AML1-ETO
分子名称: Protein CBFA2T1, ZINC ION
著者Liu, Y.Z, Chen, W, Gaudet, J, Cheney, M.D, Roudaia, L, Cierpicki, T, Klet, R.C, Hartman, K, Laue, T.M, Speck, N.A, Bushweller, J.H.
登録日2006-12-21
公開日2007-06-19
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity.
Cancer Cell, 11, 2007
6WUW
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BU of 6wuw by Molmil
Crystal structure of Human Serum Albumin complex with JMS-053
分子名称: 1,2-ETHANEDIOL, 7-imino-2-phenylthieno[3,2-c]pyridine-4,6(5H,7H)-dione, MYRISTIC ACID, ...
著者Czub, M.P, Cooper, D.R, Shabalin, I.G, Lazo, J.S, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2020-05-05
公開日2020-05-20
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of the Complex of an Iminopyridinedione Protein Tyrosine Phosphatase 4A3 Phosphatase Inhibitor with Human Serum Albumin.
Mol.Pharmacol., 98, 2020
1YBO
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BU of 1ybo by Molmil
Crystal structure of the PDZ tandem of human syntenin with syndecan peptide
分子名称: Syndecan-4, Syntenin 1
著者Grembecka, J, Cooper, D.R, Cierpicki, T, Kang, B.S, Devedjiev, Y, Derewenda, Z.
登録日2004-12-21
公開日2006-01-10
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The binding of the PDZ tandem of syntenin to target proteins
Biochemistry, 45, 2006
2BQQ
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BU of 2bqq by Molmil
X-ray Structure of the N-terminal Domain of Human Doublecortin
分子名称: NEURONAL MIGRATION PROTEIN DOUBLECORTIN
著者Kim, M.H, Cooper, D.R, Derewenda, U, Derewenda, Z.S.
登録日2005-04-27
公開日2006-07-19
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The Dc-Module of Doublecortin: Dynamics, Domain Boundaries, and Functional Implications.
Proteins, 64, 2006
1W9E
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BU of 1w9e by Molmil
Crystal structure of the PDZ tandem of human syntenin in complex with TNEFYF peptide
分子名称: BENZOIC ACID, SYNTENIN 1, TNEFYF PEPTIDE
著者Grembecka, J, Cierpicki, T, Devedjiev, Y, Cooper, D.R, Derewenda, U, Derewenda, Z.S.
登録日2004-10-09
公開日2006-03-22
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献The Binding of the Pdz Tandem of Syntenin to Target Proteins.
Biochemistry, 45, 2006
1W9O
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BU of 1w9o by Molmil
Crystal structure of the PDZ tandem of human syntenin in complex with TNEYYV peptide
分子名称: BENZOIC ACID, SYNTENIN 1, TNEYYV PEPTIDE
著者Grembecka, J, Cierpicki, T, Devedjiev, Y, Cooper, D.R, Derewenda, U, Derewenda, Z.S.
登録日2004-10-15
公開日2006-03-22
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献The Binding of the Pdz Tandem of Syntenin to Target Proteins.
Biochemistry, 45, 2006
1W9Q
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BU of 1w9q by Molmil
Crystal structure of the PDZ tandem of human syntenin in complex with TNEFAF peptide
分子名称: BENZOIC ACID, SYNTENIN 1, TNEFAF PEPTIDE
著者Grembecka, J, Cierpicki, T, Devedjiev, Y, Cooper, D.R, Derewenda, Z.S.
登録日2004-10-15
公開日2006-03-22
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The Binding of the Pdz Tandem of Syntenin to Target Proteins.
Biochemistry, 45, 2006
1V1T
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BU of 1v1t by Molmil
Crystal structure of the PDZ tandem of human syntenin in complex with TNEYKV peptide
分子名称: BENZOIC ACID, SYNTENIN 1, TNEYKV PEPTIDE
著者Grembecka, J, Cierpicki, T, Devedjiev, Y, Cooper, D.R, Derewenda, U, Derewenda, Z.S.
登録日2004-04-23
公開日2005-06-14
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The Binding of the Pdz Tandem of Syntenin to Target Proteins.
Biochemistry, 45, 2006
2KYG
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BU of 2kyg by Molmil
Structure of the AML1-ETO Nervy Domain - PKA(RIIa) complex and its contribution to AML1-ETO activity
分子名称: Protein CBFA2T1, cAMP-dependent protein kinase type II-alpha regulatory subunit
著者Corpora, T.A, Cierpecki, T, Bushweller, J.
登録日2010-05-25
公開日2010-10-20
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structure of the AML1-ETO NHR3-PKA(RIIalpha) complex and its contribution to AML1-ETO activity.
J.Mol.Biol., 402, 2010
2N2N
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BU of 2n2n by Molmil
Tom1 negatively modulates binding of Tollip to phosphatidylinositol 3-phosphate via a coupled folding and binding mechanism
分子名称: Target of Myb protein 1
著者Xiao, S, Armstrong, G, Capelluto, D.
登録日2015-05-11
公開日2015-09-16
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Tom1 Modulates Binding of Tollip to Phosphatidylinositol 3-Phosphate via a Coupled Folding and Binding Mechanism.
Structure, 23, 2015
2N31
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BU of 2n31 by Molmil
Tom1 negatively modulates binding of Tollip to phosphatidylinositol 3-phosphate via a coupled folding and binding mechanism
分子名称: Toll interacting protein variant
著者Xiao, S, Armstrong, G, Capelluto, D.
登録日2015-05-19
公開日2015-09-16
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Tom1 Modulates Binding of Tollip to Phosphatidylinositol 3-Phosphate via a Coupled Folding and Binding Mechanism.
Structure, 23, 2015
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