5T31
| Exploiting an Asp-Glu switch in Glycogen Synthase Kinase 3 to design paralog selective inhibitors for use in acute myeloid leukemia | 分子名称: | (4~{S})-4-ethyl-7,7-dimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one, Glycogen synthase kinase-3 beta | 著者 | Stein, A.J, Holson, E.B, Wagner, F.F, Cambell, A.J. | 登録日 | 2016-08-24 | 公開日 | 2018-02-21 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med, 10, 2018
|
|
8IGZ
| Xcc NAMPT Quadruple mutant | 分子名称: | Pre-B cell enhancing factor related protein | 著者 | Xu, G.L, Ming, Z.H. | 登録日 | 2023-02-21 | 公開日 | 2024-02-28 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | 主引用文献 | Structural insights into Xanthomonas campestris pv. campestris NAD + biosynthesis via the NAM salvage pathway. Commun Biol, 7, 2024
|
|
4ZO1
| Crystal Structure of the T3-bound TR-beta Ligand-binding Domain in complex with RXR-alpha | 分子名称: | 3,5,3'TRIIODOTHYRONINE, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha, ... | 著者 | Bruning, J.B, Kojetin, D.J, Matta-Camacho, E, Hughes, T.S, Srinivasan, S, Nwachukwu, J.C, Cavett, V, Nowak, J, Chalmers, M.J, Marciano, D.P, Kamenecka, T.M, Rance, M, Shulman, A.I, Mangelsdorf, D.J, Griffin, P.R, Nettles, K.W. | 登録日 | 2015-05-05 | 公開日 | 2015-09-02 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.221 Å) | 主引用文献 | Structural mechanism for signal transduction in RXR nuclear receptor heterodimers. Nat Commun, 6, 2015
|
|
5SWW
| Crystal Structure of Human APOBEC3A complexed with ssDNA | 分子名称: | DNA 15-Mer, DNA dC->dU-editing enzyme APOBEC-3A, GLYCEROL, ... | 著者 | Shi, K, Banerjee, S, Kurahashi, K, Aihara, H. | 登録日 | 2016-08-09 | 公開日 | 2016-12-28 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.151 Å) | 主引用文献 | Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B. Nat. Struct. Mol. Biol., 24, 2017
|
|
3B5R
| |
5TD5
| Crystal Structure of Human APOBEC3B variant complexed with ssDNA | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DNA (5'-D(P*TP*TP*CP*AP*T)-3'), ... | 著者 | Shi, K, Banerjee, S, Kurahashi, K, Aihara, H. | 登録日 | 2016-09-16 | 公開日 | 2016-12-28 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.718 Å) | 主引用文献 | Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B. Nat. Struct. Mol. Biol., 24, 2017
|
|
3B66
| Crystal structure of the androgen receptor ligand binding domain in complex with SARM S-21 | 分子名称: | 4-{[(1R,2S)-1,2-dihydroxy-2-methyl-3-(4-nitrophenoxy)propyl]amino}-2-(trifluoromethyl)benzonitrile, Androgen receptor | 著者 | Bohl, C.E, Miller, D.D, Dalton, J.T. | 登録日 | 2007-10-27 | 公開日 | 2008-09-09 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators Bioorg.Med.Chem.Lett., 18, 2008
|
|
3B67
| |
3B65
| |
3B68
| |
7YO8
| |
7YO9
| |
4PKS
| Anthrax toxin lethal factor with bound small molecule inhibitor 11 | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Lethal factor, ... | 著者 | Maize, K.M, De la Mora, T, Finzel, B.C. | 登録日 | 2014-05-15 | 公開日 | 2014-11-12 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr.,Sect.D, 70, 2014
|
|
4PKR
| Anthrax toxin lethal factor with bound small molecule inhibitor 10 | 分子名称: | CHLORIDE ION, GLYCEROL, Lethal factor, ... | 著者 | Maize, K.M, De la Mora, T, Finzel, B.C. | 登録日 | 2014-05-15 | 公開日 | 2014-11-12 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr.,Sect.D, 70, 2014
|
|
4PKU
| Anthrax toxin lethal factor with bound small molecule inhibitor 15 | 分子名称: | Lethal factor, N~2~-(3-aminobenzyl)-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION | 著者 | Maize, K.M, De la Mora, T, Finzel, B.C. | 登録日 | 2014-05-15 | 公開日 | 2014-11-12 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr.,Sect.D, 70, 2014
|
|
4PKW
| Anthrax toxin lethal factor with bound small molecule inhibitor GM6001 | 分子名称: | 1,2-ETHANEDIOL, 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE, GLYCEROL, ... | 著者 | Maize, K.M, De la Mora, T, Finzel, B.C. | 登録日 | 2014-05-15 | 公開日 | 2014-11-12 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr.,Sect.D, 70, 2014
|
|
4PKV
| |
4PKQ
| Anthrax toxin lethal factor with bound zinc | 分子名称: | 1,2-ETHANEDIOL, Lethal factor, TRIETHYLENE GLYCOL, ... | 著者 | Maize, K.M, Finzel, B.C. | 登録日 | 2014-05-15 | 公開日 | 2014-11-12 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr.,Sect.D, 70, 2014
|
|
4PKT
| Anthrax toxin lethal factor with bound small molecule inhibitor 13 | 分子名称: | Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-N~2~-(4-nitrobenzyl)-D-alaninamide, ZINC ION | 著者 | Maize, K.M, De la Mora, T, Finzel, B.C. | 登録日 | 2014-05-15 | 公開日 | 2014-11-12 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr.,Sect.D, 70, 2014
|
|
1K4W
| X-ray structure of the orphan nuclear receptor ROR beta ligand-binding domain in the active conformation | 分子名称: | Nuclear receptor ROR-beta, STEARIC ACID, steroid receptor coactivator-1 | 著者 | Stehlin, C, Wurtz, J.M, Steinmetz, A, Greiner, E, Schuele, R, Moras, D, Renaud, J.P. | 登録日 | 2001-10-09 | 公開日 | 2002-04-09 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation. EMBO J., 20, 2001
|
|