5C5N
 
 | | Structure of SARS-3CL protease complex with a phenyl-beta-alanyl (R,S)-N-decalin type inhibitor | | 分子名称: | (2S)-3-(1H-imidazol-5-yl)-2-({[(3R,4aS,8aR)-2-(N-phenyl-beta-alanyl)decahydroisoquinolin-3-yl]methyl}amino)propanal, 3C-like proteinase | | 著者 | Akaji, K, Teruya, K, Shimamoto, Y, Sanjho, A, Yamashita, E, Nakagawa, A. | | 登録日 | 2015-06-21 | | 公開日 | 2016-06-22 | | 最終更新日 | 2020-01-29 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Fused-ring structure of N-decalin as a novel scaffold for SARS 3CL protease inhibitors
to be published
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5C5O
 | | Structure of SARS-3CL protease complex with a phenyl-beta-alanyl (S,R)-N-decalin type inhibitor | | 分子名称: | (2S)-3-(1H-imidazol-5-yl)-2-({[(3S,4aR,8aS)-2-(N-phenyl-beta-alanyl)decahydroisoquinolin-3-yl]methyl}amino)propanal, 3C-like proteinase | | 著者 | Akaji, K, Teruya, K, Shimamoto, Y, Sanjho, A, Yamashita, E, Nakagawa, A. | | 登録日 | 2015-06-21 | | 公開日 | 2016-06-22 | | 最終更新日 | 2020-01-29 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Fused-ring structure of N-decalin as a novel scaffold for SARS 3CL protease inhibitors
to be published
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2ROM
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2RSY
 | | Solution structure of the SH2 domain of Csk in complex with a phosphopeptide from Cbp | | 分子名称: | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1, Tyrosine-protein kinase CSK | | 著者 | Tanaka, H, Akagi, K, Oneyama, C, Tanaka, M, Sasaki, Y, Kanou, T, Lee, Y, Yokogawa, D, Debenecker, M, Nakagawa, A, Okada, M, Ikegami, T. | | 登録日 | 2012-09-10 | | 公開日 | 2013-04-10 | | 最終更新日 | 2019-12-25 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Identification of a new interaction mode between the Src homology 2 domain of C-terminal Src kinase (Csk) and Csk-binding protein/phosphoprotein associated with glycosphingolipid microdomains.
J.Biol.Chem., 288, 2013
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6LYC
 | | Crystal structure of the NOD SIRPa complex with D4-2 | | 分子名称: | ACETIC ACID, D4-2, SIRPa of the NOD mouse strain | | 著者 | Murata, Y, Matsuda, M, Nakagawa, A, Matozaki, T. | | 登録日 | 2020-02-14 | | 公開日 | 2020-07-01 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | | 主引用文献 | Macrocyclic Peptide-Mediated Blockade of the CD47-SIRP alpha Interaction as a Potential Cancer Immunotherapy.
Cell Chem Biol, 27, 2020
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4U5X
 | | Structure of plant small GTPase OsRac1 complexed with the non-hydrolyzable GTP analog GMPPNP | | 分子名称: | GLYCEROL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | 著者 | Ohki, I, Kosami, K, Fujiwara, T, Nakagawa, A, Shimamoto, K, Kojima, C. | | 登録日 | 2014-07-25 | | 公開日 | 2014-08-20 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The Crystal Structure of the Plant Small GTPase OsRac1 Reveals Its Mode of Binding to NADPH Oxidase
J.Biol.Chem., 289, 2014
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5WY1
 | | Crystal structure of mouse DNA methyltransferase 1 (T1505A mutant) | | 分子名称: | DNA (cytosine-5)-methyltransferase 1, ZINC ION | | 著者 | Kanada, K, Takeshita, K, Suetake, I, Tajima, S, Nakagawa, A. | | 登録日 | 2017-01-10 | | 公開日 | 2017-05-24 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.27 Å) | | 主引用文献 | Conserved threonine 1505 in the catalytic domain stabilizes mouse DNA methyltransferase 1
J. Biochem., 162, 2017
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1GCJ
 | | N-TERMINAL FRAGMENT OF IMPORTIN-BETA | | 分子名称: | IMPORTIN BETA | | 著者 | Lee, S.J, Imamoto, N, Sakai, H, Nakagawa, A, Kose, S, Koike, M, Yamamoto, M, Kumasaka, T, Yoneda, Y, Tsukihara, T. | | 登録日 | 2000-07-31 | | 公開日 | 2000-10-18 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The adoption of a twisted structure of importin-beta is essential for the protein-protein interaction required for nuclear transport.
J.Mol.Biol., 302, 2000
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1QSH
 | | MAGNESIUM(II)-AND ZINC(II)-PROTOPORPHYRIN IX'S STABILIZE THE LOWEST OXYGEN AFFINITY STATE OF HUMAN HEMOGLOBIN EVEN MORE STRONGLY THAN DEOXYHEME | | 分子名称: | PROTEIN (HEMOGLOBIN ALPHA CHAIN), PROTEIN (HEMOGLOBIN BETA CHAIN), PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Miyazaki, G, Morimoto, H, Yun, K.-M, Park, S.-Y, Nakagawa, A, Minagawa, H, Shibayama, N. | | 登録日 | 1999-06-22 | | 公開日 | 1999-07-02 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Magnesium(II) and zinc(II)-protoporphyrin IX's stabilize the lowest oxygen affinity state of human hemoglobin even more strongly than deoxyheme.
J.Mol.Biol., 292, 1999
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1QSI
 | | MAGNESIUM(II)-AND ZINC(II)-PROTOPORPHYRIN IX'S STABILIZE THE LOWEST OXYGEN AFFINITY STATE OF HUMAN HEMOGLOBIN EVEN MORE STRONGLY THAN DEOXYHEME | | 分子名称: | CARBON MONOXIDE, PROTEIN (HEMOGLOBIN ALPHA CHAIN), PROTEIN (HEMOGLOBIN BETA CHAIN), ... | | 著者 | Miyazaki, G, Morimoto, H, Yun, K.-M, Park, S.-Y, Nakagawa, A, Minagawa, H, Shibayama, N. | | 登録日 | 1999-06-22 | | 公開日 | 1999-07-02 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Magnesium(II) and zinc(II)-protoporphyrin IX's stabilize the lowest oxygen affinity state of human hemoglobin even more strongly than deoxyheme.
J.Mol.Biol., 292, 1999
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1DPT
 | | D-DOPACHROME TAUTOMERASE | | 分子名称: | D-DOPACHROME TAUTOMERASE | | 著者 | Sugimoto, H, Taniguchi, M, Nakagawa, A, Tanaka, I. | | 登録日 | 1998-05-11 | | 公開日 | 1999-03-30 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution.
Biochemistry, 38, 1999
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1O5W
 | | The structure basis of specific recognitions for substrates and inhibitors of rat monoamine oxidase A | | 分子名称: | Amine oxidase [flavin-containing] A, FLAVIN-ADENINE DINUCLEOTIDE, N-[3-(2,4-DICHLOROPHENOXY)PROPYL]-N-METHYL-N-PROP-2-YNYLAMINE | | 著者 | Ma, J, Yoshimura, M, Yamashita, E, Nakagawa, A, Ito, A, Tsukihara, T. | | 登録日 | 2003-10-06 | | 公開日 | 2004-04-20 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structure of rat monoamine oxidase a and its specific recognitions for substrates and inhibitors.
J.Mol.Biol., 338, 2004
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5X6U
 | | Crystal structure of human heteropentameric complex | | 分子名称: | Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ... | | 著者 | Yonehara, R, Nada, S, Nakai, T, Nakai, M, Kitamura, A, Ogawa, A, Nakatsumi, H, Nakayama, K.I, Li, S, Standley, D.M, Yamashita, E, Nakagawa, A, Okada, M. | | 登録日 | 2017-02-23 | | 公開日 | 2017-12-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for the assembly of the Ragulator-Rag GTPase complex.
Nat Commun, 8, 2017
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5X6V
 | | Crystal structure of human heteroheptameric complex | | 分子名称: | ACETATE ION, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ... | | 著者 | Yonehara, R, Nada, S, Nakai, T, Nakai, M, Kitamura, A, Ogawa, A, Nakatsumi, H, Nakayama, K.I, Li, S, Standley, D.M, Yamashita, E, Nakagawa, A, Okada, M. | | 登録日 | 2017-02-23 | | 公開日 | 2017-12-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Structural basis for the assembly of the Ragulator-Rag GTPase complex.
Nat Commun, 8, 2017
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5ZFG
 | | Crystal structure of a diazinon-metabolizing glutathione S-transferase in the silkworm, Bombyx mori | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Glutathione S-transferase | | 著者 | Yamamoto, K, Higashiura, A, Nakagawa, A. | | 登録日 | 2018-03-06 | | 公開日 | 2018-09-12 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Characterisation of a diazinon-metabolising glutathione S-transferase in the silkworm Bombyx mori by X-ray crystallography and genome editing analysis.
Sci Rep, 8, 2018
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5ZF1
 | | Molecular structure of a novel 5,10-methylenetetrahydrofolate dehydrogenase from the silkworm, Bombyx mori | | 分子名称: | 1,2-ETHANEDIOL, 5,10-methylenetetrahydrofolate dehydrogenase, SULFATE ION | | 著者 | Haque, R, Higashiura, A, Nakagawa, A, Yamamoto, K. | | 登録日 | 2018-03-02 | | 公開日 | 2019-01-23 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Molecular structure of a 5,10-methylenetetrahydrofolate dehydrogenase from the silkwormBombyx mori.
FEBS Open Bio, 9, 2019
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5AZ1
 | | Crystal structure of aldo-keto reductase (AKR2E5) complexed with NADPH | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | | 著者 | Yamamoto, K, Higashiura, A, Suzuki, M, Nakagawa, A. | | 登録日 | 2015-09-15 | | 公開日 | 2016-02-10 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural characterization of an aldo-keto reductase (AKR2E5) from the silkworm Bombyx mori
Biochem.Biophys.Res.Commun., 474, 2016
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5AZ0
 | | Crystal structure of aldo-keto reductase (AKR2E5) of the silkworm, Bombyx mori | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | | 著者 | Yamamoto, K, Higashiura, A, Suzuki, M, Nakagawa, A. | | 登録日 | 2015-09-15 | | 公開日 | 2016-02-10 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural characterization of an aldo-keto reductase (AKR2E5) from the silkworm Bombyx mori
Biochem.Biophys.Res.Commun., 474, 2016
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7WJT
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4P76
 | | Cellular response to a crystal-forming protein | | 分子名称: | Photoconvertible fluorescent protein, SODIUM ION | | 著者 | Tsutsui, H, Jinno, Y, Shoda, K, Tomita, A, Matsuda, M, Yamashita, E, Katayama, H, Nakagawa, A, Miyawaki, A. | | 登録日 | 2014-03-26 | | 公開日 | 2015-04-29 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | A diffraction-quality protein crystal processed as an autophagic cargo
Mol.Cell, 58, 2015
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4TRW
 | | Structure of BACE1 complex with a syn-HEA-type inhibitor | | 分子名称: | Beta-secretase 1, L-alpha-glutamyl-L-isoleucyl-N-[(2R,3S)-1-{[(1S)-1-carboxybutyl]amino}-2-hydroxy-5-methylhexan-3-yl]-3-thiophen-2-yl-L-alaninamide | | 著者 | Akaji, K, Teruya, K, Akiyama, T, Sanjho, A, Yamashita, E, Nakagawa, A. | | 登録日 | 2014-06-18 | | 公開日 | 2015-07-01 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Evaluation of transition-state mimics in a superior BACE1 cleavage sequence as peptide-mimetic BACE1 inhibitors
Bioorg.Med.Chem., 23, 2015
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4TRZ
 | | Structure of BACE1 complex with 2-thiophenyl HEA-type inhibitor | | 分子名称: | 2-thiophenyl HEA-type inhibitor, Beta-secretase 1 | | 著者 | Akaji, K, Teruya, K, Akiyama, T, Sanjho, A, Yamashita, E, Nakagawa, A. | | 登録日 | 2014-06-18 | | 公開日 | 2015-07-01 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | Evaluation of transition-state mimics in a superior BACE1 cleavage sequence as peptide-mimetic BACE1 inhibitors
Bioorg.Med.Chem., 23, 2015
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5X71
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6IOL
 | | Cryo-EM structure of multidrug efflux pump MexAB-OprM (60 degree state) | | 分子名称: | Multidrug resistance protein MexA, Multidrug resistance protein MexB, Outer membrane protein OprM | | 著者 | Tsutsumi, K, Yonehara, R, Nakagawa, A, Yamashita, E. | | 登録日 | 2018-10-30 | | 公開日 | 2019-04-03 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.76 Å) | | 主引用文献 | Structures of the wild-type MexAB-OprM tripartite pump reveal its complex formation and drug efflux mechanism.
Nat Commun, 10, 2019
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6IOK
 | | Cryo-EM structure of multidrug efflux pump MexAB-OprM (0 degree state) | | 分子名称: | Multidrug resistance protein MexA, Multidrug resistance protein MexB, Outer membrane protein OprM | | 著者 | Tsutsumi, K, Yonehara, R, Nakagawa, A, Yamashita, E. | | 登録日 | 2018-10-30 | | 公開日 | 2019-04-03 | | 最終更新日 | 2019-04-17 | | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | | 主引用文献 | Structures of the wild-type MexAB-OprM tripartite pump reveal its complex formation and drug efflux mechanism.
Nat Commun, 10, 2019
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