5XXE
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![BU of 5xxe by Molmil](/molmil-images/mine/5xxe) | Crystal structure of Poz1 and Tpz1 | 分子名称: | Protection of telomeres protein poz1, Protection of telomeres protein tpz1, SULFATE ION, ... | 著者 | Xue, J, Chen, H, Wu, J, Lei, M. | 登録日 | 2017-07-03 | 公開日 | 2017-12-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of the fission yeast S. pombe telomeric Tpz1-Poz1-Rap1 complex. Cell Res., 27, 2017
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5XXF
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![BU of 5xxf by Molmil](/molmil-images/mine/5xxf) | Crystal structure of Poz1, Tpz1 and Rap1 | 分子名称: | Protection of telomeres protein poz1, Protection of telomeres protein tpz1, Rap1, ... | 著者 | Xue, J, Chen, H, Wu, J, Lei, M. | 登録日 | 2017-07-03 | 公開日 | 2017-12-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structure of the fission yeast S. pombe telomeric Tpz1-Poz1-Rap1 complex. Cell Res., 27, 2017
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5XUP
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![BU of 5xup by Molmil](/molmil-images/mine/5xup) | Crystal structure of TRF1 and TERB1 | 分子名称: | Telomere repeats-binding bouquet formation protein 1, Telomeric repeat-binding factor 1 | 著者 | Long, J, Huang, C, Wu, J, Lei, M. | 登録日 | 2017-06-24 | 公開日 | 2017-11-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Telomeric TERB1-TRF1 interaction is crucial for male meiosis. Nat. Struct. Mol. Biol., 24, 2017
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3K6G
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![BU of 3k6g by Molmil](/molmil-images/mine/3k6g) | Crystal structure of Rap1 and TRF2 complex | 分子名称: | Telomeric repeat-binding factor 2, Telomeric repeat-binding factor 2-interacting protein 1 | 著者 | Chen, Y, Rai, R, Yang, Y.T, Zheng, H, Chang, S, Lei, M. | 登録日 | 2009-10-08 | 公開日 | 2010-10-13 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms. Nat.Struct.Mol.Biol., 18, 2011
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8HME
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![BU of 8hme by Molmil](/molmil-images/mine/8hme) | head module state 1 of Tetrahymena IFT-A | 分子名称: | Intraflagellar transport protein 122 homolog, Intraflagellar transporter, WD40 repeat protein, ... | 著者 | Ma, Y, Wu, J, Lei, M. | 登録日 | 2022-12-03 | 公開日 | 2023-06-14 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structural insight into the intraflagellar transport complex IFT-A and its assembly in the anterograde IFT train. Nat Commun, 14, 2023
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8HMC
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![BU of 8hmc by Molmil](/molmil-images/mine/8hmc) | base module state 1 of Tetrahymena IFT-A | 分子名称: | Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 43 homolog, Tetratricopeptide repeat protein, ... | 著者 | Ma, Y, Wu, J, Lei, M. | 登録日 | 2022-12-03 | 公開日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural insight into the intraflagellar transport complex IFT-A and its assembly in the anterograde IFT train. Nat Commun, 14, 2023
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8HMD
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![BU of 8hmd by Molmil](/molmil-images/mine/8hmd) | base module state 2 of Tetrahymena IFT-A | 分子名称: | Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 43 homolog, Tetratricopeptide repeat protein, ... | 著者 | Ma, Y, Wu, J, Lei, M. | 登録日 | 2022-12-03 | 公開日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | 主引用文献 | Structural insight into the intraflagellar transport complex IFT-A and its assembly in the anterograde IFT train. Nat Commun, 14, 2023
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3CRU
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![BU of 3cru by Molmil](/molmil-images/mine/3cru) | Structural characterization of an engineered allosteric protein | 分子名称: | GLUTATHIONE, Glutathione S-transferase class-mu 26 kDa isozyme | 著者 | Sagermann, M, Chapleau, R, DeLorimier, E, Lei, M. | 登録日 | 2008-04-07 | 公開日 | 2009-02-24 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Using affinity chromatography to engineer and characterize pH-dependent protein switches. Protein Sci., 18, 2009
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3CRT
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![BU of 3crt by Molmil](/molmil-images/mine/3crt) | Structural characterization of an engineered allosteric protein | 分子名称: | GLUTATHIONE, Glutathione S-transferase class-mu 26 kDa isozyme | 著者 | Sagermann, M, Chapleau, R, DeLorimier, E, Lei, M. | 登録日 | 2008-04-07 | 公開日 | 2009-02-24 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Using affinity chromatography to engineer and characterize pH-dependent protein switches. Protein Sci., 18, 2009
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3DBQ
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![BU of 3dbq by Molmil](/molmil-images/mine/3dbq) | Crystal structure of TTK kinase domain | 分子名称: | Dual specificity protein kinase TTK | 著者 | Wang, W, Yang, Y.T, Gao, Y.F, Zhu, S.C, Wang, F, Old, W, Xu, Q.B, Resing, K, Ahn, N, Lei, M, Liu, X.D. | 登録日 | 2008-06-02 | 公開日 | 2009-02-10 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural and Mechanistic Insights into Mps1 Kinase Activation J.CELL.MOL.MED., 13, 2008
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3BU8
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![BU of 3bu8 by Molmil](/molmil-images/mine/3bu8) | Crystal Structure of TRF2 TRFH domain and TIN2 peptide complex | 分子名称: | TERF1-interacting nuclear factor 2, Telomeric repeat-binding factor 2 | 著者 | Chen, Y, Yang, Y, van Overbeek, M, Donigian, J.R, Baciu, P, de Lange, T, Lei, M. | 登録日 | 2008-01-02 | 公開日 | 2008-02-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science, 319, 2008
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5H65
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![BU of 5h65 by Molmil](/molmil-images/mine/5h65) | Crystal structure of human POT1 and TPP1 | 分子名称: | Adrenocortical dysplasia protein homolog, Protection of telomeres protein 1, ZINC ION | 著者 | Chen, C, Wu, J, Lei, M. | 登録日 | 2016-11-10 | 公開日 | 2017-05-31 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer. Nat Commun, 8, 2017
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7V2Y
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![BU of 7v2y by Molmil](/molmil-images/mine/7v2y) | cryo-EM structure of yeast THO complex with Sub2 | 分子名称: | ATP-dependent RNA helicase SUB2, Protein TEX1, THO complex subunit 2, ... | 著者 | Chen, C, Tan, M, Wu, Z, Wu, J, Lei, M. | 登録日 | 2021-08-10 | 公開日 | 2022-07-27 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex. Sci Bull (Beijing), 66, 2021
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4GM8
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![BU of 4gm8 by Molmil](/molmil-images/mine/4gm8) | Crystal structure of human WD repeat domain 5 with compound MM-102 | 分子名称: | MM-102, WD repeat-containing protein 5 | 著者 | Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S. | 登録日 | 2012-08-15 | 公開日 | 2013-07-31 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | 主引用文献 | High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J.Am.Chem.Soc., 135, 2013
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7V2W
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![BU of 7v2w by Molmil](/molmil-images/mine/7v2w) | protomer structure from the dimer of yeast THO complex | 分子名称: | Protein TEX1, THO complex subunit 2, THO complex subunit HPR1, ... | 著者 | Chen, C, Tan, M, Wu, Z, Wu, J, Lei, M. | 登録日 | 2021-08-10 | 公開日 | 2022-07-27 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex. Sci Bull (Beijing), 66, 2021
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4GMB
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![BU of 4gmb by Molmil](/molmil-images/mine/4gmb) | Crystal structure of human WD repeat domain 5 with compound MM-402 | 分子名称: | MM-402, WD repeat-containing protein 5 | 著者 | Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S. | 登録日 | 2012-08-15 | 公開日 | 2014-02-19 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.781 Å) | 主引用文献 | Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. J.Med.Chem., 60, 2017
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4GM3
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![BU of 4gm3 by Molmil](/molmil-images/mine/4gm3) | Crystal structure of human WD repeat domain 5 with compound MM-101 | 分子名称: | MM-101, WD repeat-containing protein 5 | 著者 | Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S. | 登録日 | 2012-08-15 | 公開日 | 2013-07-31 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.393 Å) | 主引用文献 | High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J.Am.Chem.Soc., 135, 2013
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4GM9
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![BU of 4gm9 by Molmil](/molmil-images/mine/4gm9) | Crystal structure of human WD repeat domain 5 with compound MM-401 | 分子名称: | MM-401, WD repeat-containing protein 5 | 著者 | Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Liu, L, Dou, Y, Lei, M, Wang, S. | 登録日 | 2012-08-15 | 公開日 | 2014-02-19 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of human WD repeat domain 5 with compound MM-401 To be Published
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7LH9
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![BU of 7lh9 by Molmil](/molmil-images/mine/7lh9) | Crystal structure of BRPF2 PWWP domain in complex with DNA | 分子名称: | Bromodomain-containing protein 1, DNA | 著者 | Zhang, M, Lei, M, Qin, S, Dong, A, Yang, A, Li, Y, Loppnau, P, Hughes, T.R, Arrowsmith, C.H, Edwards, A.M, Min, J, Liu, J, Structural Genomics Consortium (SGC) | 登録日 | 2021-01-21 | 公開日 | 2021-02-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains. Biochim Biophys Acta Gene Regul Mech, 1864, 2021
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2I46
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![BU of 2i46 by Molmil](/molmil-images/mine/2i46) | Crystal structure of human TPP1 | 分子名称: | Adrenocortical dysplasia protein homolog | 著者 | Wang, F, Podell, E.R, Zaug, A.J, Yang, Y.T, Baciu, P, Else, T, Hammer, G.D, Cech, T.R, Lei, M. | 登録日 | 2006-08-21 | 公開日 | 2006-11-28 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature, 445, 2007
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2HKO
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![BU of 2hko by Molmil](/molmil-images/mine/2hko) | Crystal structure of LSD1 | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1 | 著者 | Chen, Y, Yang, Y.T, Wang, F, Yanane, K, Zhang, Y, Lei, M. | 登録日 | 2006-07-05 | 公開日 | 2006-08-29 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of human histone lysine-specific demethylase 1 (LSD1). Proc.Natl.Acad.Sci.Usa, 103, 2006
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4I80
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2L3N
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![BU of 2l3n by Molmil](/molmil-images/mine/2l3n) | Solution structure of Rap1-Taz1 fusion protein | 分子名称: | DNA-binding protein rap1,Telomere length regulator taz1 | 著者 | Zhou, Z.R, Wang, F, Chen, Y, Lei, M, Hu, H. | 登録日 | 2010-09-19 | 公開日 | 2011-01-12 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms. Nat.Struct.Mol.Biol., 18, 2011
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5DOI
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![BU of 5doi by Molmil](/molmil-images/mine/5doi) | Crystal structure of Tetrahymena p45N and p19 | 分子名称: | Telomerase associated protein p45, Telomerase-associated protein 19 | 著者 | Wan, B, Tang, T, Wu, J, Lei, M. | 登録日 | 2015-09-11 | 公開日 | 2015-11-25 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex Nat.Struct.Mol.Biol., 22, 2015
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5DOK
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![BU of 5dok by Molmil](/molmil-images/mine/5dok) | Crystal structure of Tetrahymena p45C | 分子名称: | MAGNESIUM ION, Telomerase associated protein p45 | 著者 | Wan, B, Tang, T, Wu, J, Lei, M. | 登録日 | 2015-09-11 | 公開日 | 2015-11-25 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex Nat.Struct.Mol.Biol., 22, 2015
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