8XBE
| Human GPR34 -Gi complex bound to S3E-LysoPS | 分子名称: | (2~{S})-2-azanyl-3-[[(2~{R})-1-ethoxy-3-[(~{Z})-octadec-9-enoyl]oxy-propan-2-yl]oxy-oxidanyl-phosphoryl]oxy-propanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Kawahara, R, Shihoya, W, Nureki, O. | 登録日 | 2023-12-06 | 公開日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis for lysophosphatidylserine recognition by GPR34. Nat Commun, 15, 2024
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8XBI
| Human GPR34 -Gi complex bound to M1, receptor focused | 分子名称: | (2~{S})-2-azanyl-3-[[(2~{R})-1-ethoxy-3-[3-[2-[(3-phenoxyphenyl)methoxy]phenyl]propanoyloxy]propan-2-yl]oxy-oxidanyl-phosphoryl]oxy-propanoic acid, Probable G-protein coupled receptor 34 | 著者 | Kawahara, R, Shihoya, W, Nureki, O. | 登録日 | 2023-12-06 | 公開日 | 2023-12-27 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Structural basis for lysophosphatidylserine recognition by GPR34. Nat Commun, 15, 2024
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8XBH
| Human GPR34 -Gi complex bound to M1 | 分子名称: | (2~{S})-2-azanyl-3-[[(2~{R})-1-ethoxy-3-[3-[2-[(3-phenoxyphenyl)methoxy]phenyl]propanoyloxy]propan-2-yl]oxy-oxidanyl-phosphoryl]oxy-propanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Kawahara, R, Shihoya, W, Nureki, O. | 登録日 | 2023-12-06 | 公開日 | 2023-12-27 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | Structural basis for lysophosphatidylserine recognition by GPR34. Nat Commun, 15, 2024
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7C4S
| Sphingosine-1-phosphate receptor 3 with a natural ligand. | 分子名称: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, ... | 著者 | Iwata, S, Maeda, S, Luo, F, Nango, E, hirata, K, Asada, H. | 登録日 | 2020-05-18 | 公開日 | 2021-06-09 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Endogenous agonist-bound S1PR3 structure reveals determinants of G protein-subtype bias. Sci Adv, 7, 2021
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7DFP
| Human dopamine D2 receptor in complex with spiperone | 分子名称: | 8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one, D(2) dopamine receptor,Soluble cytochrome b562, FabH, ... | 著者 | Im, D, Shimamura, T, Iwata, S. | 登録日 | 2020-11-09 | 公開日 | 2020-12-30 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structure of the dopamine D 2 receptor in complex with the antipsychotic drug spiperone. Nat Commun, 11, 2020
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6JOD
| Angiotensin II type 2 receptor with ligand | 分子名称: | Angiotensin II, Heavy chain of 4A03Fab, Light chain of 4A03Fab, ... | 著者 | Asada, H, Iwata, S, Hirata, K, Shimamura, T. | 登録日 | 2019-03-20 | 公開日 | 2020-01-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone. Structure, 28, 2020
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4GTY
| Crystal structure of mouse Enpp1 in complex with GMP | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Kato, K, Nishimasu, H, Ishitani, R, Nureki, O. | 登録日 | 2012-08-29 | 公開日 | 2012-11-07 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | 主引用文献 | Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling. Proc.Natl.Acad.Sci.USA, 109, 2012
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4GTX
| Crystal structure of mouse Enpp1 in complex with TMP | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Kato, K, Nishimasu, H, Ishitani, R, Nureki, O. | 登録日 | 2012-08-29 | 公開日 | 2012-11-07 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.201 Å) | 主引用文献 | Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling. Proc.Natl.Acad.Sci.USA, 109, 2012
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4GTW
| Crystal structure of mouse Enpp1 in complex with AMP | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE MONOPHOSPHATE, ... | 著者 | Kato, K, Nishimasu, H, Ishitani, R, Nureki, O. | 登録日 | 2012-08-29 | 公開日 | 2012-11-07 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling. Proc.Natl.Acad.Sci.USA, 109, 2012
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4GTZ
| Crystal structure of mouse Enpp1 in complex with CMP | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Kato, K, Nishimasu, H, Ishitani, R, Nureki, O. | 登録日 | 2012-08-29 | 公開日 | 2012-11-07 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.191 Å) | 主引用文献 | Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling. Proc.Natl.Acad.Sci.USA, 109, 2012
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6OSA
| human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in non-canonical conformation (NC state) | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Kato, H.E, Zhang, Y, Kobilka, B.K, Skiniotis, G. | 登録日 | 2019-05-01 | 公開日 | 2019-07-10 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Conformational transitions of a neurotensin receptor 1-Gi1complex. Nature, 572, 2019
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6OS9
| human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in canonical conformation (C state) | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Kato, H.E, Zhang, Y, Kobilka, B.K, Skiniotis, G. | 登録日 | 2019-05-01 | 公開日 | 2019-07-10 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Conformational transitions of a neurotensin receptor 1-Gi1complex. Nature, 572, 2019
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6KS0
| Crystal structure of the human adiponectin receptor 1 | 分子名称: | Adiponectin receptor protein 1, PHOSPHATE ION, The heavy chain variable domain (Antibody), ... | 著者 | Tanabe, H, Fujii, Y, Nakamura, Y, Hosaka, T, Okada-Iwabu, M, Iwabu, M, Kimura-Someya, T, Shirouzu, M, Yamauchi, T, Kadowaki, T, Yokoyama, S. | 登録日 | 2019-08-22 | 公開日 | 2020-08-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | 主引用文献 | Human adiponectin receptor AdipoR1 assumes closed and open structures. Commun Biol, 3, 2020
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6KRZ
| Crystal structure of the human adiponectin receptor 1 D208A mutant | 分子名称: | (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Adiponectin receptor protein 1, OLEIC ACID, ... | 著者 | Tanabe, H, Fujii, Y, Okada-Iwabu, M, Iwabu, M, Yamauchi, T, Kadowaki, T, Yokoyama, S. | 登録日 | 2019-08-22 | 公開日 | 2020-08-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Human adiponectin receptor AdipoR1 assumes closed and open structures. Commun Biol, 3, 2020
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6KS1
| Crystal structure of the human adiponectin receptor 2 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, ... | 著者 | Tanabe, H, Fujii, Y, Nakamura, Y, Hosaka, T, Okada-Iwabu, M, Iwabu, M, Kimura-Someya, T, Shirouzu, M, Yamauchi, T, Kadowaki, T, Yokoyama, S. | 登録日 | 2019-08-22 | 公開日 | 2020-08-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Human adiponectin receptor AdipoR1 assumes closed and open structures. Commun Biol, 3, 2020
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6LEH
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3WAV
| Crystal Structure of Autotaxin in Complex with Compound 10 | 分子名称: | (5Z)-5-(3,4-dichlorobenzylidene)-2-(4-methylpiperazin-1-yl)-1,3-thiazol-4(5H)-one, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Nishimasu, H, Ishitani, R, Nureki, O. | 登録日 | 2013-05-09 | 公開日 | 2013-07-31 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.797 Å) | 主引用文献 | Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe Acs Chem.Biol., 8, 2013
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6LPB
| Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Kobayashi, K, Shihoya, W, Nishizawa, T, Nureki, O. | 登録日 | 2020-01-09 | 公開日 | 2020-03-11 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein. Nat.Struct.Mol.Biol., 27, 2020
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3WAW
| Crystal Structure of Autotaxin in Complex with 2BoA | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Nishimasu, H, Ishitani, R, Nureki, O. | 登録日 | 2013-05-09 | 公開日 | 2013-07-31 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.954 Å) | 主引用文献 | Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe Acs Chem.Biol., 8, 2013
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3WAX
| Crystal Structure of Autotaxin in Complex with 3BoA | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Nishimasu, H, Ishitani, R, Nureki, O. | 登録日 | 2013-05-09 | 公開日 | 2013-07-31 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.899 Å) | 主引用文献 | Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe Acs Chem.Biol., 8, 2013
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3WAY
| Crystal Structure of Autotaxin in Complex with 4BoA | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Nishimasu, H, Ishitani, R, Nureki, O. | 登録日 | 2013-05-09 | 公開日 | 2013-07-31 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.746 Å) | 主引用文献 | Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe Acs Chem.Biol., 8, 2013
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4GEL
| Crystal structure of Zucchini | 分子名称: | 1,2-ETHANEDIOL, Mitochondrial cardiolipin hydrolase, PHOSPHATE ION, ... | 著者 | Nishimasu, H, Fukuhara, S, Ishitani, R, Nureki, O. | 登録日 | 2012-08-02 | 公開日 | 2012-10-17 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.756 Å) | 主引用文献 | Structure and function of Zucchini endoribonuclease in piRNA biogenesis Nature, 491, 2012
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4GEM
| Crystal structure of Zucchini (K171A) | 分子名称: | 1,2-ETHANEDIOL, Mitochondrial cardiolipin hydrolase, ZINC ION | 著者 | Nishimasu, H, Fukuhara, S, Ishitani, R, Nureki, O. | 登録日 | 2012-08-02 | 公開日 | 2012-10-17 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.206 Å) | 主引用文献 | Structure and function of Zucchini endoribonuclease in piRNA biogenesis Nature, 491, 2012
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4GEN
| Crystal structure of Zucchini (monomer) | 分子名称: | CHLORIDE ION, Mitochondrial cardiolipin hydrolase | 著者 | Nishimasu, H, Fukuhara, S, Ishitani, R, Nureki, O. | 登録日 | 2012-08-02 | 公開日 | 2012-10-17 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure and function of Zucchini endoribonuclease in piRNA biogenesis Nature, 491, 2012
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5X93
| Human endothelin receptor type-B in complex with antagonist K-8794 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[6-[(4-tert-butylphenyl)sulfonylamino]-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]oxy-N-(2,6-dimethylphenyl)propanamide, CHOLESTEROL, ... | 著者 | Shihoya, W, Nishizawa, T, Yamashita, K, Hirata, K, Okuta, A, Tani, K, Fujiyoshi, Y, Doi, T, Nureki, O. | 登録日 | 2017-03-05 | 公開日 | 2017-08-16 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog Nat. Struct. Mol. Biol., 24, 2017
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