6H50
| Crystal structure of human KDM5B in complex with compound 34a | 分子名称: | 1,2-ETHANEDIOL, 8-[4-(1-methylpiperidin-4-yl)pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, ... | 著者 | Le Bihan, Y.V, Velupillai, S, van Montfort, R.L.M. | 登録日 | 2018-07-23 | 公開日 | 2019-06-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays. Eur.J.Med.Chem., 177, 2019
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6H4R
| Crystal structure of human KDM4A in complex with compound 17f | 分子名称: | 8-[4-[2-[4-[4-[2-(dimethylamino)ethyl]phenyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | 著者 | Le Bihan, Y.V, van Montfort, R.L.M. | 登録日 | 2018-07-23 | 公開日 | 2019-06-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays. Eur.J.Med.Chem., 177, 2019
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6H4Z
| Crystal structure of human KDM5B in complex with compound 16a | 分子名称: | 1,2-ETHANEDIOL, 8-[4-[2-[4-(3-chlorophenyl)piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, ... | 著者 | Le Bihan, Y.V, Velupillai, S, van Montfort, R.L.M. | 登録日 | 2018-07-23 | 公開日 | 2019-06-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays. Eur.J.Med.Chem., 177, 2019
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5ACY
| N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 1-(2R,4S)-2-methyl-4-(phenylamino)-6-4-(piperidin-1-ylmethyl)phenyl-1,2,3,4- tetrahydroquinolin-1-yl-ethan-1-one | 分子名称: | 1,2-ETHANEDIOL, 1-[(2S,4R)-2-methyl-4-(phenylamino)-6-[4-(piperidin-1-ylmethyl)phenyl]-3,4-dihydroquinolin-1(2H)-yl]ethanone, BROMODOMAIN-CONTAINING PROTEIN 4 | 著者 | Chung, C. | 登録日 | 2015-08-18 | 公開日 | 2015-10-07 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Autism-Like Syndrome is Induced by Pharmacological Suppression of Bet Proteins in Young Mice. J.Exp.Med., 212, 2015
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5B2Q
| Crystal structure of Francisella novicida Cas9 RHA in complex with sgRNA and target DNA (TGG PAM) | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | 著者 | Hirano, H, Nishimasu, H, Nakane, T, Ishitani, R, Nureki, O. | 登録日 | 2016-02-01 | 公開日 | 2016-03-02 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure and Engineering of Francisella novicida Cas9 Cell, 164, 2016
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5B43
| Crystal structure of Acidaminococcus sp. Cpf1 in complex with crRNA and target DNA | 分子名称: | 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cpf1, DNA (34-MER), ... | 著者 | Yamano, T, Nishimasu, H, Hirano, H, Nakane, T, Ishitani, R, Nureki, O. | 登録日 | 2016-03-30 | 公開日 | 2016-05-04 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA Cell, 165, 2016
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3E64
| Fragment based discovery of JAK-2 inhibitors | 分子名称: | 4-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzenesulfonamide, Tyrosine-protein kinase JAK2 | 著者 | Antonysamy, S, Fang, W, Hirst, G, Park, F, Russell, M, Smyth, L, Sprengeler, P, Stappenbeck, F, Steensma, R, Thompson, D.A, Wilson, M, Wong, M, Zhang, A, Zhang, F. | 登録日 | 2008-08-14 | 公開日 | 2008-10-14 | 最終更新日 | 2012-02-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Fragment-based discovery of JAK-2 inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
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5B2O
| Crystal structure of Francisella novicida Cas9 in complex with sgRNA and target DNA (TGG PAM) | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | 著者 | Hirano, H, Nishimasu, H, Nakane, T, Ishitani, R, Nureki, O. | 登録日 | 2016-02-01 | 公開日 | 2016-03-02 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure and Engineering of Francisella novicida Cas9 Cell, 164, 2016
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6XLO
| Crystal structure of bRaf in complex with inhibitor | 分子名称: | 3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide, IODIDE ION, Serine/threonine-protein kinase B-raf | 著者 | Yin, J, Eigenbrot, C, Wang, W. | 登録日 | 2020-06-28 | 公開日 | 2021-05-26 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.493 Å) | 主引用文献 | Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3 H )-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor. J.Med.Chem., 64, 2021
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7RQZ
| Cryo-EM structure of the full-length TRPV1 with RTx at 48 degrees Celsius, in an open state, class alpha | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
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7RQY
| Cryo-EM structure of the full-length TRPV1 with RTx at 25 degrees Celsius, in an open state, class B | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
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7RQX
| Cryo-EM structure of the full-length TRPV1 with RTx at 25 degrees Celsius, in an intermediate-open state, class A | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
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7RQU
| Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in a closed state, class I | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, SODIUM ION, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
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7RQW
| Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in an open state, class III | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
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7RQV
| Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in an intermediate-closed state, class II | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
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5B2P
| Crystal structure of Francisella novicida Cas9 in complex with sgRNA and target DNA (TGA PAM) | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | 著者 | Hirano, H, Nishimasu, H, Nakane, T, Ishitani, R, Nureki, O. | 登録日 | 2016-02-01 | 公開日 | 2016-03-02 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure and Engineering of Francisella novicida Cas9 Cell, 164, 2016
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3E63
| Fragment based discovery of JAK-2 inhibitors | 分子名称: | 5-phenyl-1H-indazol-3-amine, Tyrosine-protein kinase JAK2 | 著者 | Antonysamy, S, Fang, W, Hirst, G, Park, F, Russell, M, Smyth, L, Sprengeler, P, Stappenbeck, F, Steensma, R, Thompson, D.A, Wilson, M, Wong, M, Zhang, A, Zhang, F. | 登録日 | 2008-08-14 | 公開日 | 2008-10-14 | 最終更新日 | 2012-02-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Fragment-based discovery of JAK-2 inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
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3E62
| Fragment based discovery of JAK-2 inhibitors | 分子名称: | 5-bromo-1H-indazol-3-amine, Tyrosine-protein kinase JAK2 | 著者 | Antonysamy, S, Fang, W, Hirst, G, Park, F, Russell, M, Smyth, L, Sprengeler, P, Stappenbeck, F, Steensma, R, Thompson, D.A, Wilson, M, Wong, M, Zhang, A, Zhang, F. | 登録日 | 2008-08-14 | 公開日 | 2008-10-14 | 最終更新日 | 2012-02-08 | 実験手法 | X-RAY DIFFRACTION (1.922 Å) | 主引用文献 | Fragment-based discovery of JAK-2 inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
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6J22
| Crystal structure of Bi-functional enzyme | 分子名称: | Histidine biosynthesis bifunctional protein HisIE | 著者 | Zhang, H, Shang, G, Wang, Y. | 登録日 | 2018-12-30 | 公開日 | 2020-01-01 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural analysis of Shigella flexneri bi-functional enzyme HisIE in histidine biosynthesis. Biochem.Biophys.Res.Commun., 516, 2019
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6LNA
| YdiU complex with AMPNPP and Mn2+ | 分子名称: | CALCIUM ION, MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Li, B, Yang, Y, Ma, Y. | 登録日 | 2019-12-28 | 公開日 | 2020-12-30 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.701 Å) | 主引用文献 | The YdiU Domain Modulates Bacterial Stress Signaling through Mn 2+ -Dependent UMPylation. Cell Rep, 32, 2020
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6J2L
| Crystal structure of Bi-functional enzyme | 分子名称: | Histidine biosynthesis bifunctional protein HisIE, MAGNESIUM ION, ZINC ION | 著者 | Zhang, H, Shang, G, Wang, Y. | 登録日 | 2019-01-01 | 公開日 | 2020-01-01 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Structural analysis of Shigella flexneri bi-functional enzyme HisIE in histidine biosynthesis. Biochem.Biophys.Res.Commun., 516, 2019
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6MZG
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6MZE
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6MZF
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5CZZ
| Crystal structure of Staphylococcus aureus Cas9 in complex with sgRNA and target DNA (TTGAAT PAM) | 分子名称: | 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas9, DNA (28-MER), ... | 著者 | Nishimasu, H, Ishitani, R, Nureki, O. | 登録日 | 2015-08-01 | 公開日 | 2015-09-02 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal Structure of Staphylococcus aureus Cas9. Cell, 162, 2015
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