4WWN
| Crystal structure of human PI3K-gamma in complex with (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine AMG319 inhibitor | 分子名称: | N-{(1S)-1-[7-fluoro-2-(pyridin-2-yl)quinolin-3-yl]ethyl}-9H-purin-6-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | 著者 | Whittington, D.A, Tang, J, Yakowec, P. | 登録日 | 2014-11-11 | 公開日 | 2014-12-17 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Discovery and in Vivo Evaluation of (S)-N-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and Related PI3K delta Inhibitors for Inflammation and Autoimmune Disease. J.Med.Chem., 58, 2015
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6AGI
| Crystal Structure of EFHA2 in Ca-binding State | 分子名称: | CALCIUM ION, Calcium uptake protein 3, mitochondrial, ... | 著者 | Yangfei, X, Xue, Y, Yuequan, S. | 登録日 | 2018-08-11 | 公開日 | 2019-01-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.799 Å) | 主引用文献 | Dimerization of MICU Proteins Controls Ca2+Influx through the Mitochondrial Ca2+Uniporter. Cell Rep, 26, 2019
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6AIC
| Crystal structures of the N-terminal domain of Staphylococcus aureus DEAD-box Cold shock RNA helicase CshA in complex with AMP | 分子名称: | ADENOSINE MONOPHOSPHATE, DEAD-box ATP-dependent RNA helicase CshA | 著者 | Tian, T, Chengliang, W, Xiaobao, C, Xuan, Z, Jianye, Z. | 登録日 | 2018-08-22 | 公開日 | 2018-11-21 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structures of the N-terminal domain of the Staphylococcus aureus DEAD-box RNA helicase CshA and its complex with AMP Acta Crystallogr F Struct Biol Commun, 74, 2018
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6LRU
| Marsupenaeus japonicus ferritin mutant (T158H) | 分子名称: | FE (III) ION, Ferritin, IMIDAZOLE, ... | 著者 | Zhao, G, Tan, X, Zhang, T. | 登録日 | 2020-01-16 | 公開日 | 2020-11-25 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Converting histidine-induced 3D protein arrays in crystals into their 3D analogues in solution by metal coordination cross-linking. Commun Chem, 2020
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5YQX
| Crystal Structure Analysis of the BRD4 | 分子名称: | (2R)-2-(cyclopropylmethyl)-7-(3,5-dimethyl-1,2-oxazol-4-yl)-4H-1,4-benzoxazin-3-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ... | 著者 | Xue, X, Zhang, Y, Wang, C, Song, M. | 登録日 | 2017-11-08 | 公開日 | 2018-11-28 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Benzoxazinone-containing 3,5-dimethylisoxazole derivatives as BET bromodomain inhibitors for treatment of castration-resistant prostate cancer. Eur.J.Med.Chem., 152, 2018
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6LRV
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8HBT
| AmAT7-3 mutant A310G | 分子名称: | AmAT7-3-A310G, Astragaloside IV | 著者 | Wang, L.L. | 登録日 | 2022-10-31 | 公開日 | 2023-09-13 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Characterization and structure-based protein engineering of a regiospecific saponin acetyltransferase from Astragalus membranaceus. Nat Commun, 14, 2023
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8HNB
| Cryo-EM structure of human OATP1B1 in apo state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Solute carrier organic anion transporter family member 1B1 | 著者 | Shan, Z, Yang, X, Zhang, Y. | 登録日 | 2022-12-07 | 公開日 | 2023-09-13 | 最終更新日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | 主引用文献 | Cryo-EM structures of human organic anion transporting polypeptide OATP1B1. Cell Res., 33, 2023
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8H8I
| Triterpenoid saponin acetyltransferase, AmAT7-3 | 分子名称: | AmAT7-3, Astragaloside IV | 著者 | Wang, L.L. | 登録日 | 2022-10-22 | 公開日 | 2023-09-13 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Characterization and structure-based protein engineering of a regiospecific saponin acetyltransferase from Astragalus membranaceus. Nat Commun, 14, 2023
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8HNH
| Cryo-EM structure of human OATP1B1 in complex with simeprevir | 分子名称: | (2R,3aR,10Z,11aS,12aR,14aR)-N-(cyclopropylsulfonyl)-2-({7-methoxy-8-methyl-2-[4-(1-methylethyl)-1,3-thiazol-2-yl]quinolin-4-yl}oxy)-5-methyl-4,14-dioxo-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydrocyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Shan, Z, Yang, X, Zhang, Y. | 登録日 | 2022-12-07 | 公開日 | 2023-09-13 | 最終更新日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (3.73 Å) | 主引用文献 | Cryo-EM structures of human organic anion transporting polypeptide OATP1B1. Cell Res., 33, 2023
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6YS3
| Cryo-EM structure of the 50S ribosomal subunit at 2.58 Angstroms with modeled GBC SecM peptide | 分子名称: | 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | 著者 | Schulte, L, Reitz, J, Kudlinzki, D, Hodirnau, V.V, Frangakis, A, Schwalbe, H. | 登録日 | 2020-04-20 | 公開日 | 2020-09-30 | 実験手法 | ELECTRON MICROSCOPY (2.58 Å) | 主引用文献 | Cryo-EM structure of the 50S ribosomal subunit at 2.58 Angstroms with modeled GBC SecM peptide Nat Commun, 2020
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4WWO
| Crystal structure of human PI3K-gamma in complex with phenylquinoline inhibitor N-{(1S)-1-[8-chloro-2-(3-fluorophenyl)quinolin-3-yl]ethyl}-9H-purin-6-amine | 分子名称: | N-{(1S)-1-[8-chloro-2-(3-fluorophenyl)quinolin-3-yl]ethyl}-9H-purin-6-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | 著者 | Whittington, D.A, Tang, J, Yakowec, P. | 登録日 | 2014-11-11 | 公開日 | 2014-12-17 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discovery and in Vivo Evaluation of (S)-N-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and Related PI3K delta Inhibitors for Inflammation and Autoimmune Disease. J.Med.Chem., 58, 2015
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6OTS
| Rat ERK2 E320K | 分子名称: | Mitogen-activated protein kinase 1 | 著者 | Taylor, C.A, Cormier, K.W, Juang, Y.-C, Goldsmith, E.J, Cobb, M.H. | 登録日 | 2019-05-03 | 公開日 | 2019-07-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Functional divergence caused by mutations in an energetic hotspot in ERK2. Proc.Natl.Acad.Sci.USA, 116, 2019
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8FEZ
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8PHI
| Crystal structure of prefusion-stabilized RSV F Variant DS-Cav1 in complex with Lonafarnib | 分子名称: | 2-(2-METHOXYETHOXY)ETHANOL, 4-{2-[4-(3,10-DIBROMO-8-CHLORO-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXAMIDE, CALCIUM ION, ... | 著者 | Rajak, M, Krey, T. | 登録日 | 2023-06-19 | 公開日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.289 Å) | 主引用文献 | Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor. Nat Commun, 15, 2024
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7YMD
| Cryo-EM structure of Nse1/3/4 | 分子名称: | Non-structural maintenance of chromosome element 3, Non-structural maintenance of chromosome element 4, Non-structural maintenance of chromosomes element 1 | 著者 | Qian, L, Jun, Z, Zhenguo, C, Wang, L. | 登録日 | 2022-07-28 | 公開日 | 2024-01-31 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (4.176 Å) | 主引用文献 | Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms. Nat.Struct.Mol.Biol., 2024
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5Y9P
| Staphylococcus aureus RNase HII | 分子名称: | GLYCEROL, Ribonuclease HII | 著者 | Hang, T, Wu, M, Zhang, X. | 登録日 | 2017-08-26 | 公開日 | 2018-08-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural insights into a novel functional dimer of Staphylococcus aureus RNase HII Biochem. Biophys. Res. Commun., 503, 2018
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7V0E
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8HPB
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7WA9
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8HQB
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4LK2
| Crystal structure of RNA splicing effector Prp5 | 分子名称: | NICKEL (II) ION, Pre-mRNA-processing ATP-dependent RNA helicase PRP5 | 著者 | Zhang, Z.-M, Li, J, Yang, F, Xu, Y, Zhou, J. | 登録日 | 2013-07-05 | 公開日 | 2013-12-11 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Crystal structure of Prp5p reveals interdomain interactions that impact spliceosome assembly. Cell Rep, 5, 2013
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8HMH
| The closed state of RGLG2-VWA | 分子名称: | E3 ubiquitin-protein ligase RGLG2, MAGNESIUM ION | 著者 | Wang, Q. | 登録日 | 2022-12-03 | 公開日 | 2023-12-27 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | The regulation of RGLG2-VWA by Ca 2+ ions. Biochim Biophys Acta Proteins Proteom, 1872, 2024
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6M6I
| Structure of HSV2 B-capsid portal vertex | 分子名称: | Coiled coils chain 1, Coiled coils chain 2, Major capsid protein, ... | 著者 | Wang, X.X, Wang, N. | 登録日 | 2020-03-14 | 公開日 | 2021-03-10 | 実験手法 | ELECTRON MICROSCOPY (4.05 Å) | 主引用文献 | Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation. Protein Cell, 11, 2020
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6M6H
| Structure of HSV2 C-capsid portal vertex | 分子名称: | Capsid vertex component 1, Capsid vertex component 2, Large tegument protein deneddylase, ... | 著者 | Wang, X.X, Wang, N. | 登録日 | 2020-03-14 | 公開日 | 2021-03-24 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation. Protein Cell, 11, 2020
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