2LND
 
 | | Solution NMR Structure of DE NOVO DESIGNED PROTEIN, PFK fold, Northeast Structural Genomics Consortium Target OR134 | | 分子名称: | DE NOVO DESIGNED PROTEIN, PFK fold | | 著者 | Liu, G, Koga, N, Koga, R, Xiao, R, Lee, H, Janjua, H, Kohan, E, Acton, T.B, Everett, J.K, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2011-12-23 | | 公開日 | 2012-01-25 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Northeast Structural Genomics Consortium Target OR134
To be Published
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2LR0
 | | Solution NMR structure of de novo designed protein, p-loop ntpase fold, northeast structural genomics consortium target or136 | | 分子名称: | P-loop ntpase fold | | 著者 | Liu, G, Koga, N, Koga, R, Xiao, R, Lee, H, Janjua, H, Kohan, E, Acton, T.B, Everett, J.K, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2012-03-19 | | 公開日 | 2012-07-04 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution NMR structure of de novo designed protein, p-loop ntpase fold, northeast structural genomics consortium target or136
To be Published
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2MME
 | | Hybrid structure of the Shigella flexneri MxiH Type three secretion system needle | | 分子名称: | MxiH | | 著者 | Demers, J.P, Habenstein, B, Loquet, A, Vasa, S.K, Becker, S, Baker, D, Lange, A, Sgourakis, N.G. | | 登録日 | 2014-03-14 | | 公開日 | 2014-10-08 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (7.7 Å), SOLID-STATE NMR | | 主引用文献 | High-resolution structure of the Shigella type-III secretion needle by solid-state NMR and cryo-electron microscopy.
Nat Commun, 5, 2014
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4ILS
 | | Crystal structure of engineered protein. northeast structural genomics Consortium target or117 | | 分子名称: | Engineered protein | | 著者 | Seetharaman, J, Lew, S, Nivon, L, Baker, D, Bjelic, S, Ciccosanti, C, Sahdev, S, Xiao, R, Everett, J.K, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2012-12-31 | | 公開日 | 2013-03-20 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structure of engineered protein. northeast structural genomics Consortium target or117
To be Published
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4IX0
 | | Computational Design of an Unnatural Amino Acid Metalloprotein with Atomic Level Accuracy | | 分子名称: | NICKEL (II) ION, SULFATE ION, Unnatural Amino Acid Mediated Metalloprotein | | 著者 | Mills, J, Bolduc, J, Khare, S, Stoddard, B, Baker, D. | | 登録日 | 2013-01-24 | | 公開日 | 2013-08-21 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Computational design of an unnatural amino Acid dependent metalloprotein with atomic level accuracy.
J.Am.Chem.Soc., 135, 2013
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4J9T
 | | Crystal structure of a putative, de novo designed unnatural amino acid dependent metalloprotein, northeast structural genomics consortium target OR61 | | 分子名称: | ARSENIC, GLYCEROL, designed unnatural amino acid dependent metalloprotein | | 著者 | Forouhar, F, Lew, S, Seetharaman, J, Mills, J.H, Khare, S.D, Everett, J.K, Baker, D, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2013-02-17 | | 公開日 | 2013-03-27 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Computational design of an unnatural amino Acid dependent metalloprotein with atomic level accuracy.
J.Am.Chem.Soc., 135, 2013
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4HB7
 | | The Structure of Dihydropteroate Synthase from Staphylococcus aureus subsp. aureus Mu50. | | 分子名称: | 1,2-ETHANEDIOL, Dihydropteroate synthase | | 著者 | Cuff, M.E, Holowicki, J, Jedrzejczak, R, Terwilliger, T.C, Rubin, E.J, Guinn, K, Baker, D, Ioerger, T.R, Sacchettini, J.C, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI) | | 登録日 | 2012-09-27 | | 公開日 | 2012-10-17 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | The Structure of Dihydropteroate Synthase from Staphylococcus aureus subsp. aureus Mu50.
TO BE PUBLISHED
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4IWW
 | | Computational Design of an Unnatural Amino Acid Metalloprotein with Atomic Level Accuracy | | 分子名称: | COBALT (II) ION, SULFATE ION, Unnatural Amino Acid Mediated Metalloprotein | | 著者 | Mills, J, Bolduc, J, Khare, S, Stoddard, B, Baker, D. | | 登録日 | 2013-01-24 | | 公開日 | 2013-08-21 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Computational design of an unnatural amino Acid dependent metalloprotein with atomic level accuracy.
J.Am.Chem.Soc., 135, 2013
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7SKN
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7UHC
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7UHB
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5WOD
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3CQU
 | | Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor | | 分子名称: | Glycogen synthase kinase-3 beta, N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, RAC-alpha serine/threonine-protein kinase | | 著者 | Pandit, J. | | 登録日 | 2008-04-03 | | 公開日 | 2008-05-27 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Synthesis and structure based optimization of novel Akt inhibitors
Bioorg.Med.Chem.Lett., 18, 2008
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3LF9
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8C3W
 | | Crystal structure of a computationally designed heme binding protein, dnHEM1 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Ortmayer, M, Levy, C. | | 登録日 | 2022-12-29 | | 公開日 | 2023-07-05 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site.
J.Am.Chem.Soc., 145, 2023
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3MIS
 | | I-MsoI re-designed for altered DNA cleavage specificity (-8G) | | 分子名称: | CALCIUM ION, DNA (5'-D(*CP*GP*GP*AP*GP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*CP*CP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*GP*GP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*CP*TP*CP*CP*G)-3'), ... | | 著者 | Taylor, G.K, Stoddard, B.L. | | 登録日 | 2010-04-12 | | 公開日 | 2010-05-19 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs.
Nucleic Acids Res., 38, 2010
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8TL7
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8V2D
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8V3B
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4PEK
 | | Crystal structure of a computationally designed retro-aldolase, RA114.3 | | 分子名称: | Retro-aldolase | | 著者 | Bhabha, G, Zhang, X, Liu, Y, Ekiert, D.C. | | 登録日 | 2014-04-23 | | 公開日 | 2015-04-08 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | De novo-designed enzymes as small-molecule-regulated fluorescence imaging tags and fluorescent reporters.
J.Am.Chem.Soc., 136, 2014
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5IEN
 | | Structure of CDL2.2, a computationally designed Vitamin-D3 binder | | 分子名称: | 3-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANOL, CDL2.2, GLYCEROL | | 著者 | Stoddard, B.L, Doyle, L.A. | | 登録日 | 2016-02-25 | | 公開日 | 2017-03-01 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.089 Å) | | 主引用文献 | Unintended specificity of an engineered ligand-binding protein facilitated by unpredicted plasticity of the protein fold.
Protein Eng.Des.Sel., 31, 2018
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4PEJ
 | | Crystal structure of a computationally designed retro-aldolase, RA110.4 (Cys free) | | 分子名称: | Retro-aldolase | | 著者 | Bhabha, G, Zhang, X, Liu, Y, Ekiert, D.C. | | 登録日 | 2014-04-23 | | 公開日 | 2015-04-08 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | De novo-designed enzymes as small-molecule-regulated fluorescence imaging tags and fluorescent reporters.
J.Am.Chem.Soc., 136, 2014
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5IEO
 | | Structure of CDL2.3a, a computationally designed Vitamin-D3 binder | | 分子名称: | 1,2-ETHANEDIOL, 3-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANOL, CDL2.3a | | 著者 | Stoddard, B.L, Doyle, L.A. | | 登録日 | 2016-02-25 | | 公開日 | 2017-03-01 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.851 Å) | | 主引用文献 | Unintended specificity of an engineered ligand-binding protein facilitated by unpredicted plasticity of the protein fold.
Protein Eng.Des.Sel., 31, 2018
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4W4M
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6Q38
 | | The Crystal structure of CK2a bound to P1-C4 | | 分子名称: | 3,5-bis(1-methyl-1,2,3-triazol-4-yl)benzoic acid, BENZOIC ACID, Casein kinase II subunit alpha, ... | | 著者 | Brear, P, Iegre, J, Baker, D, Tan, Y, Sore, H, Donovan, D, Spring, D, Chandra, V, Hyvonen, M. | | 登録日 | 2018-12-03 | | 公開日 | 2019-04-24 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Efficient development of stable and highly functionalised peptides targeting the CK2 alpha /CK2 beta protein-protein interaction.
Chem Sci, 10, 2019
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