5XF8
 
 | | Cryo-EM structure of the Cdt1-MCM2-7 complex in AMPPNP state | | 分子名称: | Cell division cycle protein CDT1, DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, ... | | 著者 | Zhai, Y, Cheng, E, Wu, H, Li, N, Yung, P.Y, Gao, N, Tye, B.K. | | 登録日 | 2017-04-09 | | 公開日 | 2017-05-03 | | 実験手法 | ELECTRON MICROSCOPY (7.1 Å) | | 主引用文献 | Open-ringed structure of the Cdt1-Mcm2-7 complex as a precursor of the MCM double hexamer
Nat. Struct. Mol. Biol., 24, 2017
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4IA9
 | | Crystal structure of human WD REPEAT DOMAIN 5 in complex with 2-chloro-4-fluoro-3-methyl-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide | | 分子名称: | 1,2-ETHANEDIOL, 2-chloro-4-fluoro-3-methyl-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide, UNKNOWN ATOM OR ION, ... | | 著者 | Dong, A, Dombrovski, L, Bolshan, Y, Getlik, M, Tempel, W, Kuznetsova, E, Wasney, G.A, Hajian, T, Poda, G, Nguyen, K.T, Schapira, M, Brown, P.J, Al-awar, R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Smil, D, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC) | | 登録日 | 2012-12-06 | | 公開日 | 2012-12-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction.
ACS Med Chem Lett, 4, 2013
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2ND4
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2NA6
 | | Transmembrane domain of mouse Fas/CD95 death receptor | | 分子名称: | Tumor necrosis factor receptor superfamily member 6 | | 著者 | Fu, Q, Chou, J.J, Wu, H, Fu, T, Membrane Protein Structures by Solution NMR (MPSbyNMR) | | 登録日 | 2015-12-21 | | 公開日 | 2016-01-27 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor.
Mol.Cell, 61, 2016
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4IJD
 | | Crystal structure of methyltransferase domain of human PR domain-containing protein 9 | | 分子名称: | Histone-lysine N-methyltransferase PRDM9, UNKNOWN ATOM OR ION, ZINC ION | | 著者 | Dong, A, Dombrovski, L, Li, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC) | | 登録日 | 2012-12-21 | | 公開日 | 2013-02-13 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Crystal structure of methyltransferase domain of human PR domain-containing protein 9
To be Published
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3SKJ
 | | Structural And Functional Characterization of an Agonistic Anti-Human EphA2 Monoclonal Antibody | | 分子名称: | Antibody, heavy chain, light chain, ... | | 著者 | Oganesyan, V.Y, Wu, H, Dall'Acqua, W.F. | | 登録日 | 2011-06-22 | | 公開日 | 2011-08-31 | | 最終更新日 | 2017-05-31 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural and functional characterization of an agonistic anti-human EphA2 monoclonal antibody.
J.Mol.Biol., 413, 2011
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3RBN
 | | Crystal structure of MutL protein homolog 1 isoform 1 [Homo sapiens] | | 分子名称: | DNA mismatch repair protein Mlh1 | | 著者 | Dong, A, Dombrovsky, L, Wernimont, A, Loppnau, P, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC) | | 登録日 | 2011-03-29 | | 公開日 | 2011-04-27 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | | 主引用文献 | Crystal structure of MutL protein homolog 1 isoform 1 [Homo sapiens]
To be Published
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4JKV
 | | Structure of the human smoothened 7TM receptor in complex with an antitumor agent | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-fluoro-N-methyl-N-{1-[4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl]piperidin-4-yl}-2-(trifluoromethyl)benzamide, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Wang, C, Wu, H, Katritch, V, Han, G.W, Huang, X, Liu, W, Siu, F.Y, Roth, B.L, Cherezov, V, Stevens, R.C, GPCR Network (GPCR) | | 登録日 | 2013-03-11 | | 公開日 | 2013-04-24 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Structure of the human smoothened receptor bound to an antitumour agent.
Nature, 497, 2013
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2NS5
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8P1R
 | | Bifidobacterium asteroides alpha-L-fucosidase (TT1819) catalytic mutant. | | 分子名称: | 1,2-ETHANEDIOL, Bifidobacterium asteroides alpha-L-fucosidase (TT1819) catalytic mutant, MAGNESIUM ION | | 著者 | Owen, C.D, Penner, M, Gascuena, A.N, Wu, H, Hernando, P.J, Monaco, S, Le Gall, G, Gardner, R, Ndeh, D, Urbanowicz, P.A, Spencer, D.I.R, Walsh, M.A, Angulo, J, Juge, N. | | 登録日 | 2023-05-12 | | 公開日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.659 Å) | | 主引用文献 | Exploring sequence, structure and function of microbial fucosidases from glycoside hydrolase GH29 family
To Be Published
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8P1S
 | | Bifidobacterium asteroides alpha-L-fucosidase (TT1819) in complex with fucose. | | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Bifidobacterium asteroides alpha-L-fucosidase (TT1819), ... | | 著者 | Owen, C.D, Penner, M, Gascuena, A.N, Wu, H, Hernando, P.J, Monaco, S, Le Gall, G, Gardner, R, Ndeh, D, Urbanowicz, P.A, Spencer, D.I.R, Walsh, M.A, Angulo, J, Juge, N. | | 登録日 | 2023-05-12 | | 公開日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Exploring sequence, structure and function of microbial fucosidases from glycoside hydrolase GH29 family
To Be Published
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7K5I
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2OB0
 | | Human MAK3 homolog in complex with Acetyl-CoA | | 分子名称: | ACETYL COENZYME *A, Human MAK3 homolog | | 著者 | Walker, J.R, Schuetz, S, Antoshenko, T, Wu, H, Bernstein, G, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | | 登録日 | 2006-12-18 | | 公開日 | 2006-12-26 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure of Human MAK3 homolog
To be Published
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2OF5
 | | Oligomeric Death Domain complex | | 分子名称: | Death domain-containing protein CRADD, Leucine-rich repeat and death domain-containing protein | | 著者 | Park, H.H, Logette, E, Raunser, S, Cuenin, S, Walz, T, Tschopp, J, Wu, H. | | 登録日 | 2007-01-02 | | 公開日 | 2007-04-17 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex.
Cell(Cambridge,Mass.), 128, 2007
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2PKU
 | | Solution structure of PICK1 PDZ in complex with the carboxyl tail peptide of GluR2 | | 分子名称: | PRKCA-binding protein, peptide (GLU)(SER)(VAL)(LYS)(ILE) | | 著者 | Pan, L, Wu, H, Shen, C, Shi, Y, Xia, J, Zhang, M. | | 登録日 | 2007-04-18 | | 公開日 | 2007-11-20 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes
Embo J., 26, 2007
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4KFP
 | | Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived Ureas as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | | 分子名称: | 1,2-ETHANEDIOL, N-(4-{[1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl]sulfonyl}benzyl)-2H-pyrrolo[3,4-c]pyridine-2-carboxamide, Nicotinamide phosphoribosyltransferase, ... | | 著者 | Dragovich, P.S, Bair, K.W, Baumeister, T, Ho, Y, Liederer, B.M, Liu, X, O'Brien, T, Oeh, J, Sampath, D, Skelton, N, Wang, L, Wang, W, Wu, H, Xiao, Y, Yuen, P, Zak, M, Zhang, L, Zheng, X. | | 登録日 | 2013-04-27 | | 公開日 | 2013-08-14 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 23, 2013
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2QL1
 | | Structural Characterization of a Mutated, ADCC-Enhanced Human Fc Fragment | | 分子名称: | IGHM protein, ZINC ION, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Oganesyan, V, Wu, H, Dall'Acqua, W.F. | | 登録日 | 2007-07-12 | | 公開日 | 2008-04-01 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.534 Å) | | 主引用文献 | Structural characterization of a mutated, ADCC-enhanced human Fc fragment
Mol.Immunol., 45, 2008
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2PON
 | | Solution structure of the Bcl-xL/Beclin-1 complex | | 分子名称: | Apoptosis regulator Bcl-X, Beclin-1 | | 著者 | Feng, W, Huang, S, Wu, H, Zhang, M. | | 登録日 | 2007-04-27 | | 公開日 | 2007-09-04 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Molecular Basis of Bcl-xL's Target Recognition Versatility Revealed by the Structure of Bcl-xL in Complex with the BH3 Domain of Beclin-1.
J.Mol.Biol., 372, 2007
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2PSW
 | | Human MAK3 homolog in complex with CoA | | 分子名称: | COENZYME A, N-acetyltransferase 13 | | 著者 | Walker, J.R, Schuetz, A, Antoshenko, T, Wu, H, Bernstein, G, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | | 登録日 | 2007-05-07 | | 公開日 | 2007-06-05 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure of Human MAK3 homolog.
To be Published
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8GCE
 | | The Extracellular Domain of Integrin AlphaIIbBeta3 in Intermediate State | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Huo, T, Wu, H, Wang, Z. | | 登録日 | 2023-03-01 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | | 主引用文献 | Full-length alpha IIb beta 3 cryo-EM structure reveals intact integrin initiate-activation intrinsic architecture.
Structure, 32, 2024
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8GCD
 | | Full length Integrin AlphaIIbBeta3 in inactive state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Huo, T, Wu, H, Wang, Z. | | 登録日 | 2023-03-01 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | | 主引用文献 | Full-length alpha IIb beta 3 cryo-EM structure reveals intact integrin initiate-activation intrinsic architecture.
Structure, 32, 2024
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6L62
 | | Neutralization mechanism of a monoclonal antibody targeting a porcine circovirus type 2 Cap protein conformational epitope | | 分子名称: | Capsid protein, Heavy chain of Fab fragment, Light chain of Fab fragment | | 著者 | Sun, Z, Huang, L, Xia, D, Wei, Y, Sun, E, Zhu, H, Bian, H, Wu, H, Feng, L, Wang, J, Liu, C. | | 登録日 | 2019-10-25 | | 公開日 | 2020-02-12 | | 最終更新日 | 2020-04-29 | | 実験手法 | ELECTRON MICROSCOPY (7.2 Å) | | 主引用文献 | Neutralization Mechanism of a Monoclonal Antibody Targeting a Porcine Circovirus Type 2 Cap Protein Conformational Epitope.
J.Virol., 94, 2020
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6LM3
 | | Neutralization mechanism of a monoclonal antibody targeting a porcine circovirus type 2 Cap protein conformational epitope | | 分子名称: | Capsid protein | | 著者 | Sun, Z, Huang, L, Xia, D, Wei, Y, Sun, E, Zhu, H, Bian, H, Wu, H, Feng, L, Wang, J, Liu, C. | | 登録日 | 2019-12-24 | | 公開日 | 2020-02-12 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (6.7 Å) | | 主引用文献 | Neutralization Mechanism of a Monoclonal Antibody Targeting a Porcine Circovirus Type 2 Cap Protein Conformational Epitope.
J.Virol., 94, 2020
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2GTR
 | | Human chromodomain Y-like protein | | 分子名称: | Chromodomain Y-like protein | | 著者 | Min, J, Wu, H, Antoshenko, T, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | | 登録日 | 2006-04-28 | | 公開日 | 2006-05-09 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The Crystal Structure of Human chromodomain Y-like Protein.
To be Published
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2LGG
 | | Structure of PHD domain of UHRF1 in complex with H3 peptide | | 分子名称: | E3 ubiquitin-protein ligase UHRF1, ZINC ION, histone H3 peptide | | 著者 | Wang, C, Shen, J, Yang, Z, Chen, P, Zhao, B, Hu, W, Lan, W, Tong, X, Wu, H, Li, G, Cao, C. | | 登録日 | 2011-07-26 | | 公開日 | 2011-09-28 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger.
Cell Res., 21, 2011
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