3Q01
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4LRR
| Ternary complex between E. coli thymidylate synthase, dUMP, and F9 | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-oxo-2H-naphtho[1,8-bc]furan-6-yl 4-nitrobenzoate, SULFATE ION, ... | 著者 | Mangani, S, Pozzi, C, Ferrari, S, Costi, M.P. | 登録日 | 2013-07-20 | 公開日 | 2013-11-06 | 最終更新日 | 2013-12-11 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | 2'-Deoxyuridine 5'-Monophosphate Substrate Displacement in Thymidylate Synthase through 6-Hydroxy-2H-naphtho[1,8-bc]furan-2-one Derivatives. J.Med.Chem., 56, 2013
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2L6T
| Efficacy of an HIV-1 entry inhibitor targeting the GP41 fusion peptide | 分子名称: | VIR-576 | 著者 | Forssmann, W, The, Y, Stoll, M, Adermann, K, Albrecht, U, Barlos, K, Busmann, A, Can les-Mayordomo, A, Gimenez-Gallego, G, Hirsch, J, Jimenez-Barbero, J, Meyer-Olson, D, Muench, J, Perez-Castells, J, Staendker, L, Kirchhoff, F, Schmidt, R.E. | 登録日 | 2010-11-24 | 公開日 | 2011-01-19 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Short-term monotherapy in HIV-infected patients with a virus entry inhibitor against the gp41 fusion peptide. Sci Transl Med, 2, 2010
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2MB9
| Human Bcl10 CARD | 分子名称: | B-cell lymphoma/leukemia 10 | 著者 | Zheng, C, Bracken, C, Wu, H. | 登録日 | 2013-07-26 | 公開日 | 2013-10-16 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly. Mol.Cell, 51, 2013
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2W15
| High-resolution crystal structure of the P-I snake venom metalloproteinase BaP1 in complex with a peptidomimetic: insights into inhibitor binding | 分子名称: | (2R,3R)-N^1^-[(1S)-2,2-DIMETHYL-1-(METHYLCARBAMOYL)PROPYL]-N^4^-HYDROXY-2-(2-METHYLPROPYL)-3-{[(1,3-THIAZOL-2-YLCARBONYL)AMINO]METHYL}BUTANEDIAMIDE, GLYCEROL, ZINC ION, ... | 著者 | Lingott, T.J, Schleberger, C, Gutierrez, J.M, Merfort, I. | 登録日 | 2008-10-14 | 公開日 | 2009-06-16 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | High-Resolution Crystal Structure of the Snake Venom Metalloproteinase Bap1 Complexed with a Peptidomimetic: Insight Into Inhibitor Binding. Biochemistry, 48, 2009
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2W13
| High-resolution crystal structure of the P-I snake venom metalloproteinase BaP1 in complex with a peptidomimetic: insights into inhibitor binding | 分子名称: | (2R,3R)-N^1^-[(1S)-2,2-DIMETHYL-1-(METHYLCARBAMOYL)PROPYL]-N^4^-HYDROXY-2-(2-METHYLPROPYL)-3-{[(1,3-THIAZOL-2-YLCARBONYL)AMINO]METHYL}BUTANEDIAMIDE, ACETATE ION, GLYCEROL, ... | 著者 | Lingott, T.J, Schleberger, C, Gutierrez, J.M, Merfort, I. | 登録日 | 2008-10-14 | 公開日 | 2009-06-16 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.14 Å) | 主引用文献 | High-Resolution Crystal Structure of the Snake Venom Metalloproteinase Bap1 Complexed with a Peptidomimetic: Insight Into Inhibitor Binding. Biochemistry, 48, 2009
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3T0H
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3T0Z
| Hsp90 N-terminal domain bound to ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-alpha, MAGNESIUM ION | 著者 | Li, J. | 登録日 | 2011-07-21 | 公開日 | 2012-01-25 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.192 Å) | 主引用文献 | Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90. Acta Biochim Biophys Sin (Shanghai), 44, 2012
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2KIK
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3T10
| HSP90 N-terminal domain bound to ACP | 分子名称: | Heat shock protein HSP 90-alpha, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | 著者 | Li, J. | 登録日 | 2011-07-21 | 公開日 | 2012-01-25 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | 主引用文献 | Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90. Acta Biochim Biophys Sin (Shanghai), 44, 2012
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7JNI
| Crystal structure of the angiotensin II type 2 receptoror (AT2R) in complex with EMA401 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, FORMIC ACID, HEXANE-1,6-DIOL, ... | 著者 | Cherezov, V, Shaye, H, Han, G.W. | 登録日 | 2020-08-04 | 公開日 | 2022-02-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Inhibition of the angiotensin II type 2 receptor AT 2 R is a novel therapeutic strategy for glioblastoma. Proc.Natl.Acad.Sci.USA, 119, 2022
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4PPM
| Crystal structure of PigE: a transaminase involved in the biosynthesis of 2-methyl-3-n-amyl-pyrrole (MAP) from Serratia sp. FS14 | 分子名称: | Aminotransferase, MAGNESIUM ION, PYRIDOXAL-5'-PHOSPHATE | 著者 | Lou, X.D, Ran, T.T, Xu, D.Q, Wang, W.W. | 登録日 | 2014-02-27 | 公開日 | 2015-01-14 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of the catalytic domain of PigE: a transaminase involved in the biosynthesis of 2-methyl-3-n-amyl-pyrrole (MAP) from Serratia sp. FS14 Biochem.Biophys.Res.Commun., 447, 2014
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3BKD
| High resolution Crystal structure of Transmembrane domain of M2 protein | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Transmembrane Domain of Matrix protein M2, ... | 著者 | Stouffer, A.L, Acharya, R, Salom, D. | 登録日 | 2007-12-06 | 公開日 | 2008-01-29 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural basis for the function and inhibition of an influenza virus proton channel Nature, 451, 2008
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3CZR
| Crystal Structure of Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) in Complex with Arylsulfonylpiperazine Inhibitor | 分子名称: | (2R)-1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-(4-nitrophenyl)piperazine, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Corticosteroid 11-beta-dehydrogenase isozyme 1, ... | 著者 | Wang, Z, Sudom, A, Walker, N.P. | 登録日 | 2008-04-29 | 公開日 | 2008-06-17 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Discovery and Initial SAR of Arylsulfonylpiperazine Inhibitors of 11beta-Hydroxysteroid Dehydrogenase Type 1 (11beta-HSD1) Bioorg.Med.Chem.Lett., 18, 2008
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1PU4
| Crystal structure of human vascular adhesion protein-1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Salminen, T.A, Airenne, T.T. | 登録日 | 2003-06-24 | 公開日 | 2005-05-03 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Crystal structure of the human vascular adhesion protein-1: unique structural features with functional implications. Protein Sci., 14, 2005
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2N0X
| Three dimensional structure of EPI-X4, a human albumin-derived peptide that regulates innate immunity through the CXCR4/CXCL12 chemotactic axis and antagonizes HIV-1 entry | 分子名称: | Serum albumin | 著者 | Perez-Castells, J, Canales, A, Jimenez-Barbero, J, Gimenez-Gallego, G. | 登録日 | 2015-03-18 | 公開日 | 2015-04-29 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Discovery and characterization of an endogenous CXCR4 antagonist. Cell Rep, 11, 2015
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1UMR
| Crystal structure of the platelet activator convulxin, a disulfide linked a4b4 cyclic tetramer from the venom of Crotalus durissus terrificus | 分子名称: | CONVULXIN ALPHA, CONVULXIN BETA | 著者 | Murakami, M.T, Zela, S.P, Gava, L.M, Michelan-Duarte, S, Cintra, A.C.O, Arni, R.K. | 登録日 | 2003-08-28 | 公開日 | 2003-11-21 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal Structure of the Platelet Activator Convulxin, a Disulfide Linked A4B4 Cyclic Tetramer from the Venom of Crotalus Durissus Terrificus Biochem.Biophys.Res.Commun., 310, 2003
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1UMV
| Crystal structure of an acidic, non-myotoxic phospholipase A2 from the venom of Bothrops jararacussu | 分子名称: | CALCIUM ION, HYPOTENSIVE PHOSPHOLIPASE A2 | 著者 | Murakami, M.T, Watanabe, L, Cintra, A.C.O, Arni, R.K. | 登録日 | 2003-08-28 | 公開日 | 2003-09-18 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Crystal Structure of an Acidic Platelet Aggregation Inhibitor and Hypotensive Phospholipase A(2) in the Monomeric and Dimeric States: Insights Into its Oligomeric State Biochem.Biophys.Res.Commun., 323, 2004
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1US1
| Crystal structure of human vascular adhesion protein-1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Airenne, T.T, Nymalm, Y, Kidron, H, Soderholm, A, Johnson, M.S, Salminen, T.A. | 登録日 | 2003-11-17 | 公開日 | 2005-02-16 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal Structure of the Human Vascular Adhesion Protein-1: Unique Structural Features with Functional Implications. Protein Sci., 14, 2005
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4DXW
| Crystal structure of NavRh, a voltage-gated sodium channel | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, Ion transport protein, ... | 著者 | Zhang, X, Ren, W.L, Yan, C.Y, Wang, J.W, Yan, N. | 登録日 | 2012-02-28 | 公開日 | 2012-05-23 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.052 Å) | 主引用文献 | Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel Nature, 486, 2012
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4GMX
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3SL0
| Crystal Structure of P. falciparum arginase complexed with 2-amino-6-borono-2-(difluoromethyl)hexanoic acid | 分子名称: | 2-(difluoromethyl)-6-(dihydroxyboranyl)-L-norleucine, Arginase, MANGANESE (II) ION | 著者 | Dowling, D.P, Ilies, M, Christianson, D.W. | 登録日 | 2011-06-23 | 公開日 | 2011-07-20 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | 主引用文献 | Binding of alpha , alpha-disubstituted amino acids to arginase suggests new avenues for inhibitor design. J.Med.Chem., 54, 2011
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3SL1
| Crystal Structure of P. falciparum arginase complexed with 2-amino-6-borono-2-methylhexanoic acid | 分子名称: | 6-(dihydroxyboranyl)-2-methyl-L-norleucine, Arginase, MANGANESE (II) ION | 著者 | Dowling, D.P, Ilies, M, Christianson, D.W. | 登録日 | 2011-06-23 | 公開日 | 2011-07-20 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.902 Å) | 主引用文献 | Binding of alpha , alpha-disubstituted amino acids to arginase suggests new avenues for inhibitor design. J.Med.Chem., 54, 2011
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6B8U
| Crystals Structure of B-Raf kinase domain in complex with an Imidazopyridinyl benzamide inhibitor | 分子名称: | Serine/threonine-protein kinase B-raf, ~{N}-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methyl-phenyl]-3-(trifluoromethyl)benzamide | 著者 | Appleton, B.A, Murray, J, Shafer, C.M. | 登録日 | 2017-10-09 | 公開日 | 2017-11-22 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors. Bioorg. Med. Chem. Lett., 27, 2017
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3U1R
| Structure Analysis of A New Psychrophilic Marine Protease | 分子名称: | Alkaline metalloprotease, CALCIUM ION, ZINC ION | 著者 | Zhang, S.-C, Sun, M, Tang, L, Wang, Q.-H, Hao, J.-H, Han, Y, Hu, X.-J, Zhou, M, Lin, S.-X. | 登録日 | 2011-09-30 | 公開日 | 2012-10-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure analysis of a new psychrophilic marine protease. Plos One, 6, 2011
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