3CZR
Crystal Structure of Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) in Complex with Arylsulfonylpiperazine Inhibitor
Summary for 3CZR
Entry DOI | 10.2210/pdb3czr/pdb |
Descriptor | Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2R)-1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-(4-nitrophenyl)piperazine, ... (5 entities in total) |
Functional Keywords | oxidoreductase, 11beta, hydroxysteroid, dehydrogenase, endoplasmic reticulum, glycoprotein, lipid metabolism, membrane, microsome, nadp, polymorphism, signal-anchor, steroid metabolism, transmembrane |
Biological source | Homo sapiens (Human) |
Cellular location | Endoplasmic reticulum membrane; Single-pass type II membrane protein: P28845 |
Total number of polymer chains | 2 |
Total formula weight | 66192.96 |
Authors | Wang, Z.,Sudom, A.,Walker, N.P. (deposition date: 2008-04-29, release date: 2008-06-17, Last modification date: 2024-02-21) |
Primary citation | Sun, D.,Wang, Z.,Di, Y.,Jaen, J.C.,Labelle, M.,Ma, J.,Miao, S.,Sudom, A.,Tang, L.,Tomooka, C.S.,Tu, H.,Ursu, S.,Walker, N.,Yan, X.,Ye, Q.,Powers, J.P. Discovery and Initial SAR of Arylsulfonylpiperazine Inhibitors of 11beta-Hydroxysteroid Dehydrogenase Type 1 (11beta-HSD1) Bioorg.Med.Chem.Lett., 18:3513-3516, 2008 Cited by PubMed: 18511278DOI: 10.1016/j.bmcl.2008.05.025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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