6B8U

Crystals Structure of B-Raf kinase domain in complex with an Imidazopyridinyl benzamide inhibitor

Summary for 6B8U

• Entry DOI: 10.2210/pdb6b8u/pdb
• Descriptor: Serine/threonine-protein kinase B-raf, ~{N}-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methyl-phenyl]-3-(trifluoromethyl)benzamide (3 entities in total)
• Functional Keywords: proto-oncogene b-raf, p94, v-raf murine sarcoma viral oncogene homolog b1, oncoprotein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : P15056
• Total number of polymer chains: 2
• Total formula weight: 64732.62

Authors

Appleton, B.A.,Murray, J.,Shafer, C.M. (deposition date: 2017-10-09, release date: 2017-11-22, Last modification date: 2023-10-04)

• Primary citation: Smith, A.,Ni, Z.J.,Poon, D.,Huang, Z.,Chen, Z.,Zhang, Q.,Tandeske, L.,Merritt, H.,Shoemaker, K.,Chan, J.,Kaufman, S.,Huh, K.,Murray, J.,Appleton, B.A.,Cowan-Jacob, S.W.,Scheufler, C.,Kanazawa, T.,Jansen, J.M.,Stuart, D.,Shafer, C.M.; Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors.; Bioorg. Med. Chem. Lett., 27:5221-5224, 2017; PubMed: 29107542; DOI: 10.1016/j.bmcl.2017.10.047

Experimental method

X-RAY DIFFRACTION (2.68 Å)