6B8U
Crystals Structure of B-Raf kinase domain in complex with an Imidazopyridinyl benzamide inhibitor
Summary for 6B8U
Entry DOI | 10.2210/pdb6b8u/pdb |
Descriptor | Serine/threonine-protein kinase B-raf, ~{N}-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methyl-phenyl]-3-(trifluoromethyl)benzamide (3 entities in total) |
Functional Keywords | proto-oncogene b-raf, p94, v-raf murine sarcoma viral oncogene homolog b1, oncoprotein, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P15056 |
Total number of polymer chains | 2 |
Total formula weight | 64732.62 |
Authors | Appleton, B.A.,Murray, J.,Shafer, C.M. (deposition date: 2017-10-09, release date: 2017-11-22, Last modification date: 2023-10-04) |
Primary citation | Smith, A.,Ni, Z.J.,Poon, D.,Huang, Z.,Chen, Z.,Zhang, Q.,Tandeske, L.,Merritt, H.,Shoemaker, K.,Chan, J.,Kaufman, S.,Huh, K.,Murray, J.,Appleton, B.A.,Cowan-Jacob, S.W.,Scheufler, C.,Kanazawa, T.,Jansen, J.M.,Stuart, D.,Shafer, C.M. Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors. Bioorg. Med. Chem. Lett., 27:5221-5224, 2017 Cited by PubMed: 29107542DOI: 10.1016/j.bmcl.2017.10.047 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.68 Å) |
Structure validation
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