4F0Z
 
 | | Crystal Structure of Calcineurin in Complex with the Calcineurin-Inhibiting Domain of the African Swine Fever Virus Protein A238L | | 分子名称: | Ankyrin repeat domain-containing protein A238L, CALCIUM ION, Calcineurin subunit B type 1, ... | | 著者 | Grigoriu, S, Peti, W, Page, R. | | 登録日 | 2012-05-05 | | 公開日 | 2013-03-06 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | The molecular mechanism of substrate engagement and immunosuppressant inhibition of calcineurin.
Plos Biol., 11, 2013
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3ZPH
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6RU6
 | | Crystal structure of Casein Kinase I delta (CK1d) in complex with monophosphorylated p63 PAD1P peptide | | 分子名称: | 1,2-ETHANEDIOL, Casein kinase I isoform delta, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | | 著者 | Chaikuad, A, Tuppi, M, Gebel, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Dotsch, V, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2019-05-27 | | 公開日 | 2020-05-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | p63 uses a switch-like mechanism to set the threshold for induction of apoptosis.
Nat.Chem.Biol., 16, 2020
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6RYB
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1VSK
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4A6L
 | | beta-tryptase inhibitor | | 分子名称: | 1-{3-[1-({5-[(2-fluorophenyl)ethynyl]furan-2-yl}carbonyl)piperidin-4-yl]phenyl}methanamine, TRYPTASE ALPHA/BETA-1 | | 著者 | Mathieu, M, Maignan, S. | | 登録日 | 2011-11-04 | | 公開日 | 2012-01-25 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structure-Based Library Design and the Discovery of a Potent and Selective Mast Cell Beta-Tryptase Inhibitor as an Oral Therapeutic Agent.
Bioorg.Med.Chem.Lett., 22, 2012
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6RYA
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6RU8
 | | Crystal structure of Casein Kinase I delta (CK1d) in complex with triple phosphorylated p63 PAD3P peptide | | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, Casein kinase I isoform delta, ... | | 著者 | Chaikuad, A, Tuppi, M, Gebel, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Dotsch, V, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2019-05-27 | | 公開日 | 2020-05-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | p63 uses a switch-like mechanism to set the threshold for induction of apoptosis.
Nat.Chem.Biol., 16, 2020
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2B73
 | | T4 Lysozyme mutant L99A at 100 MPa | | 分子名称: | BETA-MERCAPTOETHANOL, CHLORIDE ION, Lysozyme | | 著者 | Collins, M.D, Quillin, M.L, Matthews, B.W, Gruner, S.M. | | 登録日 | 2005-10-03 | | 公開日 | 2005-11-08 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Cooperative water filling of a nonpolar protein cavity observed by high-pressure crystallography and simulation
Proc.Natl.Acad.Sci.Usa, 102, 2005
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7NL6
 | | Crystal Structure of DC-SIGN in complex with a triazole-based glycomimetic ligand | | 分子名称: | CALCIUM ION, DC-SIGN, CRD domain, ... | | 著者 | Jakob, R.P, Cramer, J, Lakkaichi, A, Aliu, B, Cattaneo, I, Klein, S, Jiang, X, Rabbani, S, Schwardt, O, Ernst, B, Maier, T. | | 登録日 | 2021-02-22 | | 公開日 | 2021-10-27 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Sweet Drugs for Bad Bugs: A Glycomimetic Strategy against the DC-SIGN-Mediated Dissemination of SARS-CoV-2.
J.Am.Chem.Soc., 143, 2021
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7NL7
 | | Crystal Structure of DC-SIGN in complex with a triazole-based glycomimetic ligand | | 分子名称: | 3-Aminopropyl 2-deoxy-2-(4-phenyl-1,2,3-triazol-1-yl)-alpha-D-mannopyranoside, CALCIUM ION, DC-SIGN, ... | | 著者 | Jakob, R.P, Cramer, J, Lakkaichi, A, Aliu, B, Cattaneo, I, Klein, S, Jiang, X, Rabbani, S, Schwardt, O, Ernst, B, Maier, T. | | 登録日 | 2021-02-22 | | 公開日 | 2021-10-27 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Sweet Drugs for Bad Bugs: A Glycomimetic Strategy against the DC-SIGN-Mediated Dissemination of SARS-CoV-2.
J.Am.Chem.Soc., 143, 2021
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6RU7
 | | Crystal structure of Casein Kinase I delta (CK1d) in complex with double phosphorylated p63 PAD2P peptide | | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, Casein kinase I isoform delta, ... | | 著者 | Chaikuad, A, Tuppi, M, Gebel, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Dotsch, V, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2019-05-27 | | 公開日 | 2020-05-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | p63 uses a switch-like mechanism to set the threshold for induction of apoptosis.
Nat.Chem.Biol., 16, 2020
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3M1S
 | | Structure of Ruthenium Half-Sandwich Complex Bound to Glycogen Synthase Kinase 3 | | 分子名称: | Glycogen synthase kinase-3 beta, Ruthenium pyridocarbazole | | 著者 | Atilla-Gokcumen, G.E, Di Costanzo, L, Zimmermann, G, Meggers, E. | | 登録日 | 2010-03-05 | | 公開日 | 2010-12-22 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.134 Å) | | 主引用文献 | Structure of anticancer ruthenium half-sandwich complex bound to glycogen synthase kinase 3beta
J.Biol.Inorg.Chem., 16, 2011
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6MG4
 | | Structure of full-length human lambda-6A light chain JTO | | 分子名称: | JTO light chain | | 著者 | Morgan, G.J, Yan, N.L, Mortenson, D.E, Stanfield, R.L, Wilson, I.A, Kelly, J.W. | | 登録日 | 2018-09-12 | | 公開日 | 2019-04-10 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Stabilization of amyloidogenic immunoglobulin light chains by small molecules.
Proc.Natl.Acad.Sci.USA, 116, 2019
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2B70
 | | T4 Lysozyme mutant L99A at ambient pressure | | 分子名称: | BETA-MERCAPTOETHANOL, CHLORIDE ION, Lysozyme | | 著者 | Collins, M.D, Quillin, M.L, Matthews, B.W, Gruner, S.M, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2005-10-03 | | 公開日 | 2005-11-08 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Cooperative water filling of a nonpolar protein cavity observed by high-pressure crystallography and simulation
Proc.Natl.Acad.Sci.Usa, 102, 2005
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2B75
 | | T4 Lysozyme mutant L99A at 150 MPa | | 分子名称: | BETA-MERCAPTOETHANOL, CHLORIDE ION, Lysozyme | | 著者 | Collins, M.D, Quillin, M.L, Matthews, B.W, Gruner, S.M. | | 登録日 | 2005-10-03 | | 公開日 | 2005-11-08 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Cooperative water filling of a nonpolar protein cavity observed by high-pressure crystallography and simulation
Proc.Natl.Acad.Sci.Usa, 102, 2005
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2B6W
 | | T4 Lysozyme mutant L99A at 200 MPa | | 分子名称: | BETA-MERCAPTOETHANOL, CHLORIDE ION, Lysozyme | | 著者 | Collins, M.D, Quillin, M.L, Matthews, B.W, Gruner, S.M. | | 登録日 | 2005-10-03 | | 公開日 | 2005-11-08 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Cooperative water filling of a nonpolar protein cavity observed by high-pressure crystallography and simulation
Proc.Natl.Acad.Sci.Usa, 102, 2005
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2B72
 | | T4 Lysozyme mutant L99A at 100 MPa | | 分子名称: | BETA-MERCAPTOETHANOL, CHLORIDE ION, Lysozyme | | 著者 | Collins, M.D, Quillin, M.L, Matthews, B.W, Gruner, S.M. | | 登録日 | 2005-10-03 | | 公開日 | 2005-11-08 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Cooperative water filling of a nonpolar protein cavity observed by high-pressure crystallography and simulation
Proc.Natl.Acad.Sci.Usa, 102, 2005
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2B6Z
 | | T4 Lysozyme mutant L99A at ambient pressure | | 分子名称: | BETA-MERCAPTOETHANOL, CHLORIDE ION, Lysozyme | | 著者 | Collins, M.D, Quillin, M.L, Matthews, B.W, Gruner, S.M. | | 登録日 | 2005-10-03 | | 公開日 | 2005-11-08 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Cooperative water filling of a nonpolar protein cavity observed by high-pressure crystallography and simulation
Proc.Natl.Acad.Sci.Usa, 102, 2005
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3TN0
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6VK3
 | | CryoEM structure of Hrd3/Yos9 complex | | 分子名称: | Hrd3, Protein OS-9 homolog | | 著者 | Wu, X, Rapoport, T.A. | | 登録日 | 2020-01-18 | | 公開日 | 2020-04-29 | | 最終更新日 | 2020-05-06 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex.
Science, 368, 2020
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2B6X
 | | T4 Lysozyme mutant L99A at 200 MPa | | 分子名称: | BETA-MERCAPTOETHANOL, CHLORIDE ION, Lysozyme | | 著者 | Collins, M.D, Quillin, M.L, Matthews, B.W, Gruner, S.M. | | 登録日 | 2005-10-03 | | 公開日 | 2005-11-08 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.107 Å) | | 主引用文献 | Cooperative water filling of a nonpolar protein cavity observed by high-pressure crystallography and simulation
Proc.Natl.Acad.Sci.Usa, 102, 2005
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2B6Y
 | | T4 Lysozyme mutant L99A at ambient pressure | | 分子名称: | BETA-MERCAPTOETHANOL, CHLORIDE ION, Lysozyme | | 著者 | Collins, M.D, Quillin, M.L, Matthews, B.W, Gruner, S.M. | | 登録日 | 2005-10-03 | | 公開日 | 2005-11-08 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Cooperative water filling of a nonpolar protein cavity observed by high-pressure crystallography and simulation
Proc.Natl.Acad.Sci.Usa, 102, 2005
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6VJZ
 | | CryoEM structure of Hrd1-Usa1/Der1/Hrd3 complex of the expected topology | | 分子名称: | Degradation in the endoplasmic reticulum protein 1, ERAD-associated E3 ubiquitin-protein ligase HRD1, ERAD-associated E3 ubiquitin-protein ligase component HRD3, ... | | 著者 | Wu, X, Rapoport, T.A. | | 登録日 | 2020-01-18 | | 公開日 | 2020-04-29 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex.
Science, 368, 2020
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2B6T
 | | T4 Lysozyme mutant L99A at 200 MPa | | 分子名称: | BETA-MERCAPTOETHANOL, CHLORIDE ION, Lysozyme | | 著者 | Collins, M.D, Quillin, M.L, Matthews, B.W, Gruner, S.M. | | 登録日 | 2005-10-03 | | 公開日 | 2005-11-08 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural rigidity of a large cavity-containing protein revealed by high-pressure crystallography.
J.Mol.Biol., 367, 2007
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