6RU7

Crystal structure of Casein Kinase I delta (CK1d) in complex with double phosphorylated p63 PAD2P peptide

Summary for 6RU7

Entry DOI	10.2210/pdb6ru7/pdb
Descriptor	Casein kinase I isoform delta, Tumor protein 63, ADENOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
Functional Keywords	ck1 delta, ck1delta, csnk1d, tp63, p63, kinase substrate complex, structural genomics, structural genomics consortium, sgc, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	74221.25
Authors	Chaikuad, A.,Tuppi, M.,Gebel, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Dotsch, V.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2019-05-27, release date: 2020-05-13, Last modification date: 2024-01-24)
Primary citation	Gebel, J.,Tuppi, M.,Chaikuad, A.,Hotte, K.,Schroder, M.,Schulz, L.,Lohr, F.,Gutfreund, N.,Finke, F.,Henrich, E.,Mezhyrova, J.,Lehnert, R.,Pampaloni, F.,Hummer, G.,Stelzer, E.H.K.,Knapp, S.,Dotsch, V. p63 uses a switch-like mechanism to set the threshold for induction of apoptosis. Nat.Chem.Biol., 16:1078-1086, 2020 Cited by PubMed: 32719556 DOI: 10.1038/s41589-020-0600-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.08 Å)

Structure validation