6RU6

Crystal structure of Casein Kinase I delta (CK1d) in complex with monophosphorylated p63 PAD1P peptide

Summary for 6RU6

Entry DOI	10.2210/pdb6ru6/pdb
Descriptor	Casein kinase I isoform delta, Tumor protein 63, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (7 entities in total)
Functional Keywords	ck1 delta, ck1delta, csnk1d, tp63, p63, kinase substrate complex, structural genomics, structural genomics consortium, sgc, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	71868.01
Authors	Chaikuad, A.,Tuppi, M.,Gebel, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Dotsch, V.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2019-05-27, release date: 2020-05-13, Last modification date: 2024-01-24)
Primary citation	Gebel, J.,Tuppi, M.,Chaikuad, A.,Hotte, K.,Schroder, M.,Schulz, L.,Lohr, F.,Gutfreund, N.,Finke, F.,Henrich, E.,Mezhyrova, J.,Lehnert, R.,Pampaloni, F.,Hummer, G.,Stelzer, E.H.K.,Knapp, S.,Dotsch, V. p63 uses a switch-like mechanism to set the threshold for induction of apoptosis. Nat.Chem.Biol., 16:1078-1086, 2020 Cited by PubMed: 32719556 DOI: 10.1038/s41589-020-0600-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation