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6KNE
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BU of 6kne by Molmil
The C-terminal Domain of Translation Initiation Factor 5 at high pH
分子名称: Translation initiation factor eIF5
著者Jian, Y, YuXin, Y, Min, Y.
登録日2019-08-05
公開日2020-06-17
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.701 Å)
主引用文献The pH-dependent conformational change of eukaryotic translation initiation factor 5: Insights into partner-binding manner.
Biochem.Biophys.Res.Commun., 519, 2019
6KND
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BU of 6knd by Molmil
The C-terminal Domain of Translation Initiation Factor 5 at low pH
分子名称: Translation initiation factor eIF5
著者Jian, Y, YuXin, Y, Min, Y.
登録日2019-08-05
公開日2020-06-17
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The pH-dependent conformational change of eukaryotic translation initiation factor 5: Insights into partner-binding manner.
Biochem.Biophys.Res.Commun., 519, 2019
6AH8
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BU of 6ah8 by Molmil
Marine bacterial prolidase with promiscuous organophosphorus hydrolase activity
分子名称: MANGANESE (II) ION, SULFATE ION, Xaa-Pro dipeptidase
著者Jian, Y.
登録日2018-08-17
公開日2019-09-18
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Repurposing a bacterial prolidase for organophosphorus hydrolysis: Reshaped catalytic cavity switches substrate selectivity.
Biotechnol.Bioeng., 117, 2020
6AH7
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BU of 6ah7 by Molmil
D45W/H226G mutant of marine bacterial prolidase
分子名称: MANGANESE (II) ION, SODIUM ION, SULFATE ION, ...
著者Jian, Y, Yunzhu, X, Lijuan, L.
登録日2018-08-17
公開日2019-09-18
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献Repurposing a bacterial prolidase for organophosphorus hydrolysis: Reshaped catalytic cavity switches substrate selectivity.
Biotechnol.Bioeng., 117, 2020
7XL5
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BU of 7xl5 by Molmil
Crystal structure of the H42T/A85G/I86A mutant of a nadp-dependent alcohol dehydrogenase
分子名称: NADP-dependent isopropanol dehydrogenase
著者Jiang, Y.Y, Qu, G, Li, X, Sun, Z.T, Han, X, Liu, W.D.
登録日2022-04-21
公開日2023-05-31
最終更新日2024-06-12
実験手法X-RAY DIFFRACTION (2.604 Å)
主引用文献Engineering the hydrogen transfer pathway of an alcohol dehydrogenase to increase activity by rational enzyme design
Mol Catal, 530, 2022
7FCV
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BU of 7fcv by Molmil
Cryo-EM structure of the Potassium channel AKT1 mutant from Arabidopsis thaliana
分子名称: PHOSPHATIDYLETHANOLAMINE, POTASSIUM ION, Potassium channel AKT1
著者Yang, G.H, Lu, Y.M, Jia, Y.T, Zhang, Y.M, Tang, R.F, Xu, X, Li, X.M, Lei, J.L.
登録日2021-07-15
公開日2022-11-09
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural basis for the activity regulation of a potassium channel AKT1 from Arabidopsis.
Nat Commun, 13, 2022
6UIP
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BU of 6uip by Molmil
DYRK1A Kinase Domain in Complex with a 6-azaindole Derivative, GNF2133.
分子名称: 4-ethyl-N-{4-[1-(oxan-4-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]pyridin-2-yl}piperazine-1-carboxamide, Dual specificity tyrosine-phosphorylation-regulated kinase 1A
著者DiDonato, M, Spraggon, G.
登録日2019-10-01
公開日2020-03-04
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133.
J.Med.Chem., 63, 2020
2TIO
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BU of 2tio by Molmil
LOW PACKING DENSITY FORM OF BOVINE BETA-TRYPSIN IN CYCLOHEXANE
分子名称: BENZAMIDINE, CALCIUM ION, HEXANE, ...
著者Huang, Q, Zhu, G, Tang, Q.
登録日1998-09-23
公開日1998-09-30
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献X-ray studies on two forms of bovine beta-trypsin crystals in neat cyclohexane.
Biochim.Biophys.Acta, 1429, 1998
6WYS
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BU of 6wys by Molmil
Lon protease proteolytic domain
分子名称: Lon protease homolog, mitochondrial, SULFATE ION
著者Lee, C.C, Spraggon, G.
登録日2020-05-13
公開日2021-04-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.229 Å)
主引用文献Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology.
J.Med.Chem., 64, 2021
6WZV
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BU of 6wzv by Molmil
Lon protease proteolytic domain
分子名称: Lon protease homolog, mitochondrial, N-[(1R)-1-borono-3-methylbutyl]-Nalpha-(pyrazine-2-carbonyl)-D-phenylalaninamide, ...
著者Lee, C.C, Spraggon, G.
登録日2020-05-14
公開日2021-04-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology.
J.Med.Chem., 64, 2021
6X1M
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BU of 6x1m by Molmil
Lon protease proteolytic domain complexed with covalent boronic acid inhibitor
分子名称: Lon protease homolog, mitochondrial, [(1R)-4-phenyl-1-{[N-(pyrazine-2-carbonyl)-D-norvalyl]amino}butyl]boronic acid
著者Lee, C.C, Spraggon, G.
登録日2020-05-19
公開日2021-04-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.51 Å)
主引用文献Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology.
J.Med.Chem., 64, 2021
6X27
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BU of 6x27 by Molmil
Lon protease proteolytic domain complexed with bortezomib
分子名称: GLYCEROL, Lon protease homolog, mitochondrial, ...
著者Lee, C.C, Spraggon, G.
登録日2020-05-20
公開日2021-04-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology.
J.Med.Chem., 64, 2021
6XNP
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BU of 6xnp by Molmil
Crystal Structure of Human STING CTD complex with SR-717
分子名称: 1,2-ETHANEDIOL, 4,5-difluoro-2-{[6-(1H-imidazol-1-yl)pyridazine-3-carbonyl]amino}benzoic acid, GLYCEROL, ...
著者Chin, E.N, Yu, C, Wolan, D.W, Petrassi, H.M, Lairson, L.L.
登録日2020-07-03
公開日2020-08-26
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic.
Science, 369, 2020
6XNN
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BU of 6xnn by Molmil
Crystal Structure of Mouse STING CTD complex with SR-717.
分子名称: 4,5-difluoro-2-{[6-(1H-imidazol-1-yl)pyridazine-3-carbonyl]amino}benzoic acid, Stimulator of interferon genes protein
著者Chin, E.N, Yu, C, Wolan, D.W, Petrassi, H.M, Lairson, L.L.
登録日2020-07-03
公開日2020-08-26
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic.
Science, 369, 2020
3HPM
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BU of 3hpm by Molmil
Oxidized dimeric PICK1 PDZ C46G mutant in complex with the carboxyl tail peptide of GluR2
分子名称: PRKCA-binding protein,9-mer peptide of THE GLUR2 SUBUNIT
著者Yu, J, Shi, Y, Zhang, M.
登録日2009-06-04
公開日2010-06-09
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Redox-Regulated Lipid Membrane Binding of the PICK1 PDZ Domain.
Biochemistry, 49, 2010
3HPK
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BU of 3hpk by Molmil
Oxidized dimeric PICK1 PDZ in complex with the carboxyl tail peptide of GluR2
分子名称: GLYCEROL, PRKCA-binding protein,9-mer peptide of THE GLUR2 SUBUNIT
著者Yu, J, Shi, Y, Zhang, M.
登録日2009-06-04
公開日2010-06-09
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Redox-Regulated Lipid Membrane Binding of the PICK1 PDZ Domain.
Biochemistry, 49, 2010
1TIO
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BU of 1tio by Molmil
HIGH PACKING DENSITY FORM OF BOVINE BETA-TRYPSIN IN CYCLOHEXANE
分子名称: BENZAMIDINE, CALCIUM ION, CYCLOHEXANE, ...
著者Huang, Q, Zhu, G, Wang, Z, Tang, Q.
登録日1998-09-17
公開日1998-09-23
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献X-ray studies on two forms of bovine beta-trypsin crystals in neat cyclohexane.
Biochim.Biophys.Acta, 1429, 1998
5W5O
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BU of 5w5o by Molmil
Identification of potent and selective RIPK2 inhibitors for the treatment of inflammatory diseases.
分子名称: 4-{6-(tert-butylsulfonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-6-chloropyridin-2-amine, Receptor-interacting serine/threonine-protein kinase 2
著者Kreusch, A, Spraggon, G.
登録日2017-06-15
公開日2017-10-25
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases.
ACS Med Chem Lett, 8, 2017
5W5J
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BU of 5w5j by Molmil
Identification of potent and selective RIPK2 inhibitors for the treatment of inflammatory diseases
分子名称: N-(2-chlorophenyl)pyrazolo[1,5-a]pyridine-3-carboxamide, Receptor-interacting serine/threonine-protein kinase 2, SULFATE ION
著者Kreusch, A, Spraggon, G.
登録日2017-06-15
公開日2017-10-25
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases.
ACS Med Chem Lett, 8, 2017
8IK0
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BU of 8ik0 by Molmil
Cryo-EM structure of Stimulator of interferon genes
分子名称: Stimulator of interferon genes protein,Immune protein Tsi3
著者Lu, D.F, Shang, G.J.
登録日2023-02-28
公開日2023-05-17
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献The mechanism of STING autoinhibition and activation.
Mol.Cell, 83, 2023
8IK3
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BU of 8ik3 by Molmil
Structure of Stimulator of interferon genes/ligand complex
分子名称: Stimulator of interferon genes protein,Immune protein Tsi3, cGAMP
著者Lu, D.F, Shang, G.J.
登録日2023-02-28
公開日2023-05-17
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献The mechanism of STING autoinhibition and activation.
Mol.Cell, 83, 2023
6DKA
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BU of 6dka by Molmil
Yeast Ddi2 Cyanamide Hydratase
分子名称: CYANAMIDE, DNA damage-inducible protein, SULFATE ION, ...
著者Moore, S.A, Xiao, W, Li, J.
登録日2018-05-29
公開日2019-05-08
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.901 Å)
主引用文献Structure of Ddi2, a highly inducible detoxifying metalloenzyme fromSaccharomyces cerevisiae.
J.Biol.Chem., 294, 2019
6DK9
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BU of 6dk9 by Molmil
Yeast Ddi2 Cyanamide Hydratase
分子名称: DNA damage-inducible protein, SULFATE ION, ZINC ION
著者Moore, S.A, Xiao, W, Li, J.
登録日2018-05-29
公開日2019-05-08
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of Ddi2, a highly inducible detoxifying metalloenzyme fromSaccharomyces cerevisiae.
J.Biol.Chem., 294, 2019
6DKD
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BU of 6dkd by Molmil
Yeast Ddi2 Cyanamide Hydratase
分子名称: DNA damage-inducible protein, SULFATE ION, ZINC ION
著者Moore, S.A, Xiao, W, Li, J.
登録日2018-05-29
公開日2019-05-08
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of Ddi2, a highly inducible detoxifying metalloenzyme fromSaccharomyces cerevisiae.
J.Biol.Chem., 294, 2019
6DKC
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BU of 6dkc by Molmil
Yeast Ddi2 Cyanamide Hydratase, T157V mutant, apo structure
分子名称: DNA damage-inducible protein, SULFATE ION, ZINC ION
著者Moore, S.A, Xiao, W, Li, J.
登録日2018-05-29
公開日2019-05-08
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of Ddi2, a highly inducible detoxifying metalloenzyme fromSaccharomyces cerevisiae.
J.Biol.Chem., 294, 2019

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