6UIP

DYRK1A Kinase Domain in Complex with a 6-azaindole Derivative, GNF2133.

Summary for 6UIP

Entry DOI	10.2210/pdb6uip/pdb
Descriptor	Dual specificity tyrosine-phosphorylation-regulated kinase 1A, 4-ethyl-N-{4-[1-(oxan-4-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]pyridin-2-yl}piperazine-1-carboxamide (2 entities in total)
Functional Keywords	kinase, inhibitor, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	127548.21
Authors	DiDonato, M.,Spraggon, G. (deposition date: 2019-10-01, release date: 2020-03-04, Last modification date: 2023-11-15)
Primary citation	Liu, Y.A.,Jin, Q.,Zou, Y.,Ding, Q.,Yan, S.,Wang, Z.,Hao, X.,Nguyen, B.,Zhang, X.,Pan, J.,Mo, T.,Jacobsen, K.,Lam, T.,Wu, T.Y.,Petrassi, H.M.,Bursulaya, B.,DiDonato, M.,Gordon, W.P.,Liu, B.,Baaten, J.,Hill, R.,Nguyen-Tran, V.,Qiu, M.,Zhang, Y.Q.,Kamireddy, A.,Espinola, S.,Deaton, L.,Ha, S.,Harb, G.,Jia, Y.,Li, J.,Shen, W.,Schumacher, A.M.,Colman, K.,Glynne, R.,Pan, S.,McNamara, P.,Laffitte, B.,Meeusen, S.,Molteni, V.,Loren, J. Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133. J.Med.Chem., 63:2958-2973, 2020 Cited by PubMed: 32077280 DOI: 10.1021/acs.jmedchem.9b01624 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.7 Å)

Structure validation