8GZM
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8GZK
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6JBT
| Complex structure of toripalimab-Fab and PD-1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain, ... | 著者 | Guo, L, Tan, S, Chai, Y, Qi, J, Gao, G.F, Yan, J. | 登録日 | 2019-01-26 | 公開日 | 2019-06-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Glycosylation-independent binding of monoclonal antibody toripalimab to FG loop of PD-1 for tumor immune checkpoint therapy. Mabs, 11, 2019
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7D32
| The TBA-Pb2+ complex in P41212 space group | 分子名称: | DNA (5'-D(*GP*GP*TP*TP*GP*GP*TP*GP*TP*GP*GP*TP*TP*GP*G)-3'), LEAD (II) ION | 著者 | Liu, H.H, Gao, Y.Q, Sheng, J, Gan, J.H. | 登録日 | 2020-09-18 | 公開日 | 2021-09-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.707 Å) | 主引用文献 | Structure-guided development of Pb 2+ -binding DNA aptamers. Sci Rep, 12, 2022
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7D33
| The Pb2+ complexed structure of TBA G8C mutant | 分子名称: | DNA (5'-D(*GP*GP*TP*TP*GP*GP*TP*CP*TP*GP*GP*TP*TP*GP*G)-3'), LEAD (II) ION | 著者 | Liu, H.H, Gao, Y.Q, Sheng, J, Gan, J.H. | 登録日 | 2020-09-18 | 公開日 | 2021-09-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.117 Å) | 主引用文献 | Structure-guided development of Pb 2+ -binding DNA aptamers. Sci Rep, 12, 2022
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7D31
| The TBA-Pb2+ complex in P41212 space group | 分子名称: | DNA (5'-D(*GP*GP*TP*TP*GP*GP*TP*GP*TP*GP*GP*TP*TP*GP*G)-3'), LEAD (II) ION | 著者 | Liu, H.H, Gao, Y.Q, Sheng, J, Gan, J.H. | 登録日 | 2020-09-18 | 公開日 | 2021-09-22 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.396 Å) | 主引用文献 | Structure-guided development of Pb 2+ -binding DNA aptamers. Sci Rep, 12, 2022
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7C88
| Complex structure of JS003 and PD-L1 | 分子名称: | JS003 Heavy chain, JS003 Light chain, Programmed cell death 1 ligand 1 | 著者 | Bi, X, Shi, R, Chai, Y, Qi, J, Yan, J, Tan, S. | 登録日 | 2020-05-29 | 公開日 | 2021-04-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | 主引用文献 | Identification of a hotspot on PD-L1 for pH-dependent binding by monoclonal antibodies for tumor therapy. Signal Transduct Target Ther, 5, 2020
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7XAB
| Crystal structure of PDE4D catalytic domain complexed with compound 22d | 分子名称: | 9-(cyclopropylmethoxy)-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-5-(pyridin-4-ylmethoxy)pyrano[3,2-b]xanthen-6-one, Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D, MAGNESIUM ION, ... | 著者 | Huang, Y.-Y, He, X, Luo, H.-B. | 登録日 | 2022-03-17 | 公開日 | 2023-02-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.00067449 Å) | 主引用文献 | Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases. Eur.J.Med.Chem., 242, 2022
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7XAA
| Crystal structure of PDE4D catalytic domain complexed with compound 21d | 分子名称: | 8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-9-oxidanyl-5-(pyridin-4-ylmethoxy)pyrano[3,2-b]xanthen-6-one, Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D, MAGNESIUM ION, ... | 著者 | Huang, Y.-Y, He, X, Luo, H.-B. | 登録日 | 2022-03-17 | 公開日 | 2023-02-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.100414 Å) | 主引用文献 | Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases. Eur.J.Med.Chem., 242, 2022
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7VM8
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7CPW
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1CEF
| CEFOTAXIME COMPLEXED WITH THE STREPTOMYCES R61 DD-PEPTIDASE | 分子名称: | CEFOTAXIME, C3' cleaved, open, ... | 著者 | Knox, J.R, Kuzin, A.P. | 登録日 | 1995-01-12 | 公開日 | 1996-10-14 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Binding of cephalothin and cefotaxime to D-ala-D-ala-peptidase reveals a functional basis of a natural mutation in a low-affinity penicillin-binding protein and in extended-spectrum beta-lactamases. Biochemistry, 34, 1995
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4USG
| Crystal structure of PC4 W89Y mutant complex with DNA | 分子名称: | 5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP *TP*TP*TP*TP*TP*G)-3', ACTIVATED RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR P15 | 著者 | Zhao, Y, Liu, J. | 登録日 | 2014-07-08 | 公開日 | 2015-03-18 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.973 Å) | 主引用文献 | Substitution of Tryptophan 89 with Tyrosine Switches the DNA Binding Mode of Pc4. Sci.Rep., 5, 2015
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5M8H
| ATP phosphoribosyltransferase (HisZG ATPPRT) from Psychrobacter arcticus | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ATP phosphoribosyltransferase, ATP phosphoribosyltransferase regulatory subunit, ... | 著者 | Alphey, M.S, Ge, Y, Naismith, J.H, da Silva, R.G. | 登録日 | 2016-10-28 | 公開日 | 2017-09-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Kinetics and Structure of a Cold-Adapted Hetero-Octameric ATP Phosphoribosyltransferase. Biochemistry, 56, 2017
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6SSE
| Transaminase with PMP bound | 分子名称: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, ForI-PMP, SULFATE ION | 著者 | Naismith, J.H, Gao, S. | 登録日 | 2019-09-06 | 公開日 | 2020-01-15 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | PMP-diketopiperazine adducts form at the active site of a PLP dependent enzyme involved in formycin biosynthesis. Chem.Commun.(Camb.), 55, 2019
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6SSF
| Transaminase with LCS bound | 分子名称: | ForI-LCS, SULFATE ION, [4-[(~{Z})-[(2~{S},5~{S})-5-(azanyloxymethyl)-3,6-bis(oxidanylidene)piperazin-2-yl]methoxyiminomethyl]-6-methyl-5-oxidanyl-pyridin-3-yl]methyl dihydrogen phosphate | 著者 | Naismith, J.H, Gao, S. | 登録日 | 2019-09-06 | 公開日 | 2020-01-15 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | PMP-diketopiperazine adducts form at the active site of a PLP dependent enzyme involved in formycin biosynthesis. Chem.Commun.(Camb.), 55, 2019
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6SSD
| Transaminase with PLP bound | 分子名称: | ForI-PLP, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION | 著者 | Naismith, J.H, Gao, S. | 登録日 | 2019-09-06 | 公開日 | 2020-01-15 | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | 主引用文献 | PMP-diketopiperazine adducts form at the active site of a PLP dependent enzyme involved in formycin biosynthesis. Chem.Commun.(Camb.), 55, 2019
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3ZC4
| The structure of Csa5 from Sulfolobus solfataricus. | 分子名称: | DI(HYDROXYETHYL)ETHER, SSO1398 | 著者 | Reeks, J, Anderson, L, White, M.F, Naismith, J.H. | 登録日 | 2012-11-15 | 公開日 | 2013-02-20 | 最終更新日 | 2013-07-31 | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | 主引用文献 | Structure of the Archaeal Cascade Subunit Csa5: Relating the Small Subunits of Crispr Effector Complexes. RNA Biol., 10, 2013
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2ICZ
| NMR Structures of the Expanded DNA 10bp xTGxTAxCxGCxAxGT:xACTxGCGxTAxCA | 分子名称: | 5'-D(*(XAE)P*CP*TP*(XGA)P*CP*GP*(XTY)P*AP*(XCS)P*A)-3', 5'-D(*(XTY)P*GP*(XTY)P*AP*(XCS)P*(XGA)P*CP*(XAE)P*(XGA)P*T)-3' | 著者 | Lynch, S.R. | 登録日 | 2006-09-13 | 公開日 | 2006-11-21 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Toward a Designed, Functioning Genetic System with Expanded-Size Base Pairs: Solution Structure of the Eight-Base xDNA Double Helix. J.Am.Chem.Soc., 128, 2006
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7B17
| SARS-CoV-spike RBD bound to two neutralising nanobodies. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, SARS-CoV-2 neutralizing biparatopic nanobody VE,nanobody E from Lama glama,SARS-CoV-2 neutralizing biparatopic nanobody VE,nanobody E from Lama glama, Spike protein S1 | 著者 | Hallberg, B.M, Das, H. | 登録日 | 2020-11-23 | 公開日 | 2021-02-10 | 最終更新日 | 2022-12-21 | 実験手法 | ELECTRON MICROSCOPY (4.01 Å) | 主引用文献 | Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape Science, 371, 2021
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7B14
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7B18
| SARS-CoV-spike bound to two neutralising nanobodies | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody against SARS-CoV-2 VHH E, ... | 著者 | Hallberg, B.M, Das, H. | 登録日 | 2020-11-24 | 公開日 | 2021-04-28 | 実験手法 | ELECTRON MICROSCOPY (2.62 Å) | 主引用文献 | Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape. Science, 371, 2021
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7U2E
| Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody ADI-55688 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADI-55688 heavy chain, ADI-55688 light chain, ... | 著者 | Yuan, M, Zhu, X, Wilson, I.A. | 登録日 | 2022-02-23 | 公開日 | 2022-05-04 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | A broad and potent neutralization epitope in SARS-related coronaviruses. Proc.Natl.Acad.Sci.USA, 119, 2022
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7U2D
| Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody ADG20 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADG20 heavy chain, ADG20 light chain, ... | 著者 | Zhu, X, Yuan, M, Wilson, I.A. | 登録日 | 2022-02-23 | 公開日 | 2022-05-04 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | 主引用文献 | A broad and potent neutralization epitope in SARS-related coronaviruses. Proc.Natl.Acad.Sci.USA, 119, 2022
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8X6B
| Crystal structure of immune receptor PVRIG in complex with ligand Nectin-2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Nectin-2, Transmembrane protein PVRIG | 著者 | Hu, S.T, Han, P, Wang, H, Qi, J.X. | 登録日 | 2023-11-21 | 公開日 | 2024-04-24 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for the immune recognition and selectivity of the immune receptor PVRIG for ligand Nectin-2. Structure, 2024
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