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8Y8D
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BU of 8y8d by Molmil
Structure of HCoV-HKU1C spike in the inactive-1up conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
著者Lu, Y.C, Zhang, X, Wang, H.F, Sun, L, Yang, H.T.
登録日2024-02-06
公開日2024-07-17
実験手法ELECTRON MICROSCOPY (3.41 Å)
主引用文献TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 2024
8Y8E
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BU of 8y8e by Molmil
Structure of HCoV-HKU1C spike in the inactive-2up conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Lu, Y.C, Zhang, X, Wang, H.F, Sun, L, Yang, H.T.
登録日2024-02-06
公開日2024-07-17
実験手法ELECTRON MICROSCOPY (3.62 Å)
主引用文献TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 2024
8Y8C
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BU of 8y8c by Molmil
Structure of HCoV-HKU1C spike in the inactive-closed conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Lu, Y.C, Zhang, X, Wang, H.F, Sun, L, Yang, H.T.
登録日2024-02-06
公開日2024-07-17
実験手法ELECTRON MICROSCOPY (2.95 Å)
主引用文献TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 2024
8Y87
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BU of 8y87 by Molmil
Structure of HCoV-HKU1C spike in the functionally anchored-1up conformation with 1TMPRSS2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
著者Lu, Y.C, Zhang, X, Wang, H.F, Liu, X.C, Sun, L, Yang, H.T.
登録日2024-02-06
公開日2024-07-17
実験手法ELECTRON MICROSCOPY (3.26 Å)
主引用文献TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 2024
8Y89
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BU of 8y89 by Molmil
Structure of HCoV-HKU1C spike in the functionally anchored-3up conformation with 2TMPRSS2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
著者Lu, Y.C, Wang, H.F, Zhang, X, Liu, X.C, Sun, L, Yang, H.T.
登録日2024-02-06
公開日2024-07-17
実験手法ELECTRON MICROSCOPY (3.32 Å)
主引用文献TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 2024
8Y7Y
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BU of 8y7y by Molmil
Local structure of HCoV-HKU1A spike in complex with TMPRSS2 and glycan
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
著者Wang, H.F, Zhang, X, Lu, Y, Liu, X, Sun, L, Yang, H.T.
登録日2024-02-05
公開日2024-07-17
実験手法ELECTRON MICROSCOPY (3.24 Å)
主引用文献TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 2024
8Y8G
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BU of 8y8g by Molmil
Structure of HCoV-HKU1C spike in the glycan-activated-1up conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
著者Lu, Y.C, Zhang, X, Wang, H.F, Sun, L, Yang, H.T.
登録日2024-02-06
公開日2024-07-17
実験手法ELECTRON MICROSCOPY (3.23 Å)
主引用文献TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 2024
8Y88
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BU of 8y88 by Molmil
Structure of HCoV-HKU1C spike in the functionally anchored-2up conformation with 2TMPRSS2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
著者Lu, Y.C, Zhang, X, Wang, H.F, Liu, X.C, Sun, L, Yang, H.T.
登録日2024-02-06
公開日2024-07-17
実験手法ELECTRON MICROSCOPY (3.03 Å)
主引用文献TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 2024
8Y8B
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BU of 8y8b by Molmil
Local structure of HCoV-HKU1C spike in complex with TMPRSS2 and glycan
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
著者Wang, H.F, Zhang, X, Lu, Y.C, Liu, X.C, Sun, L, Yang, H.T.
登録日2024-02-06
公開日2024-07-17
実験手法ELECTRON MICROSCOPY (3.01 Å)
主引用文献TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 2024
8Y8I
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BU of 8y8i by Molmil
Structure of HCoV-HKU1C spike in the glycan-activated-3up conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Lu, Y.C, Zhang, X, Wang, H.F, Sun, L, Yang, H.T.
登録日2024-02-06
公開日2024-07-17
実験手法ELECTRON MICROSCOPY (3.58 Å)
主引用文献TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 2024
8Y8A
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BU of 8y8a by Molmil
Structure of HCoV-HKU1C spike in the functionally anchored-3up conformation with 3TMPRSS2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
著者Lu, Y.C, Zhang, X, Wang, H.F, Liu, X.C, Sun, L, Yang, H.T.
登録日2024-02-06
公開日2024-07-17
実験手法ELECTRON MICROSCOPY (3.19 Å)
主引用文献TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 2024
8Y8H
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BU of 8y8h by Molmil
Structure of HCoV-HKU1C spike in the glycan-activated-2up conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Lu, Y.C, Zhang, X, Wang, H.F, Sun, L, Yang, H.T.
登録日2024-02-06
公開日2024-07-17
実験手法ELECTRON MICROSCOPY (3.65 Å)
主引用文献TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 2024
8Y8F
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BU of 8y8f by Molmil
Structure of HCoV-HKU1C spike in the glycan-activated-closed conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
著者Lu, Y.C, Zhang, X, Wang, H.F, Sun, L, Yang, H.T.
登録日2024-02-06
公開日2024-07-17
実験手法ELECTRON MICROSCOPY (3.07 Å)
主引用文献TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 2024
8Y8J
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BU of 8y8j by Molmil
Local structure of HCoV-HKU1C spike in complex with glycan
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
著者Lu, Y.C, Zhang, X, Wang, H.F, Sun, L, Yang, H.T.
登録日2024-02-06
公開日2024-07-17
実験手法ELECTRON MICROSCOPY (3.57 Å)
主引用文献TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 2024
8Y7X
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BU of 8y7x by Molmil
Structure of HCoV-HKU1A spike in the functionally anchored-3up conformation with 3TMPRSS2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
著者Lu, Y.C, Zhang, X, Wang, H.F, Liu, X.C, Sun, L, Yang, H.T.
登録日2024-02-05
公開日2024-07-17
実験手法ELECTRON MICROSCOPY (3.09 Å)
主引用文献TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 2024
4HVI
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BU of 4hvi by Molmil
JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((R)-1-methyl-2-oxo-2-piperidin-1-yl-ethyl)-amide
分子名称: 2-cyclopropyl-N-[(2R)-1-oxo-1-(piperidin-1-yl)propan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide, Tyrosine-protein kinase JAK3
著者Kuglstatter, A, Shao, A.
登録日2012-11-06
公開日2013-01-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models.
J.Med.Chem., 56, 2013
4HVH
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BU of 4hvh by Molmil
JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((R)-2-hydroxy-1,2-dimethyl-propyl
分子名称: 2-cyclopropyl-N-[(2R)-3-hydroxy-3-methylbutan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide, Tyrosine-protein kinase JAK3
著者Kuglstatter, A, Shao, A.
登録日2012-11-06
公開日2013-01-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models.
J.Med.Chem., 56, 2013
4HVG
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BU of 4hvg by Molmil
JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-2-hydroxy-1,2-dimethyl-propyl)-amide
分子名称: 2-cyclopropyl-N-[(2S)-3-hydroxy-3-methylbutan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide, Tyrosine-protein kinase JAK3
著者Kuglstatter, A, Shao, A.
登録日2012-11-06
公開日2013-01-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models.
J.Med.Chem., 56, 2013
4HVD
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BU of 4hvd by Molmil
JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-1,2,2-trimethyl-propyl)-amide
分子名称: 1-phenylurea, 2-cyclopropyl-N-[(2S)-3,3-dimethylbutan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide, Tyrosine-protein kinase JAK3
著者Kuglstatter, A, Shao, A.
登録日2012-11-06
公開日2013-01-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models.
J.Med.Chem., 56, 2013
6MNL
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BU of 6mnl by Molmil
NMR solution structures of second bromodomain of BRD4 with FOXO3a peptide
分子名称: Bromodomain-containing protein 4, FOXO3a peptide
著者Zeng, L, Zhou, M.-M.
登録日2018-10-02
公開日2018-10-31
最終更新日2023-11-15
実験手法SOLUTION NMR
主引用文献Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer.
Nat Commun, 9, 2018
8ENZ
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BU of 8enz by Molmil
Crystal structure of alpha-COPI-WD40 domain K15A mutant.
分子名称: ACETYL GROUP, Putative coatomer subunit alpha
著者Dey, D, Hasan, S.S.
登録日2022-09-30
公開日2024-01-31
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs.
Nat Commun, 14, 2023
8ENX
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BU of 8enx by Molmil
Crystal structure of beta'-COPI-WD40 domain Y33A mutant in complex with SARS-CoV-2 clientized spike tail heptapeptide.
分子名称: Clientized spike tail heptapeptide, Coatomer subunit beta'
著者Dey, D, Hasan, S.S.
登録日2022-09-30
公開日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs.
Nat Commun, 14, 2023
8ENY
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BU of 8eny by Molmil
Crystal structure of alpha-COPI-WD40 domain R13A mutant.
分子名称: ACETYL GROUP, Putative coatomer subunit alpha
著者Dey, D, Hasan, S.S.
登録日2022-09-30
公開日2024-01-31
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs.
Nat Commun, 14, 2023
8EO0
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BU of 8eo0 by Molmil
Crystal structure of alpha-COPI WD40 domain R300A mutant.
分子名称: ACETYL GROUP, Putative coatomer subunit alpha
著者Dey, D, Hasan, S.S.
登録日2022-10-01
公開日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs.
Nat Commun, 14, 2023
8ENS
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BU of 8ens by Molmil
Crystal structure of beta'-COPI-WD40 domain in complex with SARS-CoV-2 spike tail hepta-peptide
分子名称: Coatomer subunit beta', spike tail hepta-peptide
著者Dey, D, Hasan, S.S.
登録日2022-09-30
公開日2024-01-31
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs.
Nat Commun, 14, 2023

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件を2024-08-21に公開中

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