6Z4Q
| Crystal structure of the neurotensin receptor 1 in complex with the small-molecule inverse agonist SR142948A | 分子名称: | 2-[[5-(2,6-dimethoxyphenyl)-1-[4-[3-(dimethylamino)propyl-methyl-carbamoyl]-2-propan-2-yl-phenyl]pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid, Neurotensin receptor type 1,Neurotensin receptor type 1,DARPin | 著者 | Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A. | 登録日 | 2020-05-25 | 公開日 | 2021-02-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.923 Å) | 主引用文献 | Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism. Sci Adv, 7, 2021
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6ZIN
| Crystal structure of the neurotensin receptor 1 in complex with the small molecule inverse agonist SR48692 | 分子名称: | 2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid, Neurotensin receptor type 1,DARPin,HRV 3C protease recognition sequence | 著者 | Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A. | 登録日 | 2020-06-26 | 公開日 | 2021-02-10 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.639 Å) | 主引用文献 | Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism. Sci Adv, 7, 2021
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6Z8N
| Crystal structure of the neurotensin receptor 1 in complex with the small-molecule full agonist SRI-9829 | 分子名称: | (2~{S})-4-methyl-2-[(1-quinolin-8-ylsulfonylindol-3-yl)carbonylamino]pentanoic acid, Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor 1 (NTSR1),Neurotensin receptor 1 (NTSR1) | 著者 | Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A. | 登録日 | 2020-06-02 | 公開日 | 2021-02-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.803 Å) | 主引用文献 | Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism. Sci Adv, 7, 2021
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6YVR
| Crystal structure of the neurotensin receptor 1 in complex with the peptide full agonist NTS8-13 | 分子名称: | Neurotensin receptor type 1,Neurotensin receptor type 1,DARPin crystallisation chaperone, neurotensin NTS8-13 (full agonist), nonyl beta-D-glucopyranoside | 著者 | Deluigi, M, Merklinger, L, Hilge, M, Ernst, P, Klipp, A, Klenk, C, Plueckthun, A. | 登録日 | 2020-04-28 | 公開日 | 2021-02-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.458 Å) | 主引用文献 | Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism. Sci Adv, 7, 2021
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6Z4S
| Crystal structure of the neurotensin receptor 1 (NTSR1-H4bmx) in complex with the small molecule inverse agonist SR48692 | 分子名称: | 2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid, Neurotensin receptor type 1,DARPin,HRV 3C protease recognition sequence | 著者 | Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A. | 登録日 | 2020-05-25 | 公開日 | 2021-02-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.707 Å) | 主引用文献 | Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism. Sci Adv, 7, 2021
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6Z66
| Crystal structure of apo-state neurotensin receptor 1 | 分子名称: | Neurotensin receptor type 1,Neurotensin receptor type 1,DARPin | 著者 | Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A. | 登録日 | 2020-05-27 | 公開日 | 2021-02-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.192 Å) | 主引用文献 | Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism. Sci Adv, 7, 2021
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6ZA8
| Crystal structure of the neurotensin receptor 1 in complex with the small-molecule partial agonist RTI-3a | 分子名称: | (2~{S})-2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]-4-methyl-pentanoic acid, Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor 1 (NTSR1),Neurotensin receptor 1 (NTSR1),Neurotensin receptor type 1,Neurotensin receptor 1 (NTSR1),Neurotensin receptor 1 (NTSR1) | 著者 | Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A. | 登録日 | 2020-06-05 | 公開日 | 2021-02-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | 主引用文献 | Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism. Sci Adv, 7, 2021
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6Z4V
| Crystal structure of the neurotensin receptor 1 (NTSR1-H4bmx) in complex with NTS8-13 | 分子名称: | ARG-PRO-TYR-ILE-LEU, Neurotensin receptor type 1,Neurotensin receptor type 1,DARPin | 著者 | Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A. | 登録日 | 2020-05-25 | 公開日 | 2021-02-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.595 Å) | 主引用文献 | Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism. Sci Adv, 7, 2021
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5U8F
| Polycomb protein EED in complex with inhibitor: (3R,4S)-1-[(1S)-7-fluoro-2,3-dihydro-1H-inden-1-yl]-N,N-dimethyl-4-(1-methyl-1H-indol-3-yl)pyrrolidin-3-amine | 分子名称: | (3R,4S)-1-[(1S)-7-fluoro-2,3-dihydro-1H-inden-1-yl]-N,N-dimethyl-4-(1-methyl-1H-indol-3-yl)pyrrolidin-3-amine, Polycomb protein EED | 著者 | Jakob, C.G, Zhu, H. | 登録日 | 2016-12-14 | 公開日 | 2017-03-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.343 Å) | 主引用文献 | SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding. Bioorg. Med. Chem. Lett., 27, 2017
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5U2M
| Crystal structure of human NAMPT with A-1293201 | 分子名称: | N-[4-({[(3S)-oxolan-3-yl]methyl}carbamoyl)phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide, Nicotinamide phosphoribosyltransferase, SULFATE ION | 著者 | Longenecker, K.L, Raich, D, Korepanova, A.V. | 登録日 | 2016-11-30 | 公開日 | 2017-06-28 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors. Mol. Cancer Ther., 16, 2017
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5U8A
| Polycomb protein EED in complex with inhibitor: (3R,4S)-1-[(2-bromo-6-fluorophenyl)methyl]-N,N-dimethyl-4-(1-methyl-1H-indol-3-yl)pyrrolidin-3-amine | 分子名称: | (3R,4S)-1-[(2-bromo-6-fluorophenyl)methyl]-N,N-dimethyl-4-(1-methyl-1H-indol-3-yl)pyrrolidin-3-amine, Polycomb protein EED | 著者 | Jakob, C.G, Zhu, H. | 登録日 | 2016-12-14 | 公開日 | 2017-03-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding. Bioorg. Med. Chem. Lett., 27, 2017
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5U6D
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5U2N
| Crystal structure of human NAMPT with A-1326133 | 分子名称: | N-{4-[1-(2-methylpropanoyl)piperidin-4-yl]phenyl}-2H-pyrrolo[3,4-c]pyridine-2-carboxamide, Nicotinamide phosphoribosyltransferase, SULFATE ION | 著者 | Longenecker, K.L, Raich, D, Korepanova, A.V. | 登録日 | 2016-11-30 | 公開日 | 2017-06-28 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors. Mol. Cancer Ther., 16, 2017
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5U69
| Polycomb protein EED in complex with inhibitor: (3R,4S)-1-[(2-methoxyphenyl)methyl]-N,N-dimethyl-4-(1-methylindol-3-yl)pyrrolidin-3-amine | 分子名称: | (3R,4S)-1-[(2-methoxyphenyl)methyl]-N,N-dimethyl-4-(1-methylindol-3-yl)pyrrolidin-3-amine, Polycomb protein EED | 著者 | Jakob, C.G, Zhu, H. | 登録日 | 2016-12-07 | 公開日 | 2017-03-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | 主引用文献 | SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding. Bioorg. Med. Chem. Lett., 27, 2017
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5ZCX
| Structure of T20/N39 | 分子名称: | Envelope glycoprotein, Envelope glycoprotein gp160 | 著者 | Zhang, X.J, Ding, X.H. | 登録日 | 2018-02-21 | 公開日 | 2018-10-10 | 最終更新日 | 2018-12-19 | 実験手法 | X-RAY DIFFRACTION (2.299 Å) | 主引用文献 | Structural and functional characterization of HIV-1 cell fusion inhibitor T20. AIDS, 33, 2019
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7KJS
| Crystal structure of CDK2/cyclin E in complex with PF-06873600 | 分子名称: | 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-{[1-(methylsulfonyl)piperidin-4-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1 | 著者 | McTigue, M.A, He, Y, Ferre, R.A. | 登録日 | 2020-10-26 | 公開日 | 2021-06-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.187 Å) | 主引用文献 | Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer. J.Med.Chem., 64, 2021
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6IUG
| Cryo-EM structure of the plant actin filaments from Zea mays pollen | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, pollen F-actin | 著者 | Ren, Z.H, Zhang, Y, Zhang, Y, He, Y.Q, Du, P.Z, Wang, Z.X, Sun, F, Ren, H.Y. | 登録日 | 2018-11-28 | 公開日 | 2019-11-06 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM Structure of Actin Filaments fromZea maysPollen. Plant Cell, 31, 2019
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7LKI
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8SZX
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5GHY
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5GHZ
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5GHX
| Crystal structure of beta-lactamase PenP mutant-E166H | 分子名称: | 1,2-ETHANEDIOL, ACETIC ACID, Beta-lactamase | 著者 | Pan, X, Zhao, Y. | 登録日 | 2016-06-21 | 公開日 | 2017-01-25 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | 主引用文献 | Crystallographic Snapshots of Class A beta-Lactamase Catalysis Reveal Structural Changes That Facilitate beta-Lactam Hydrolysis J. Biol. Chem., 292, 2017
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4MQ2
| The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor | 分子名称: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, PENTAETHYLENE GLYCOL, SULFATE ION, ... | 著者 | Lukacs, C.M, Janson, C.A, Garvie, C, Liang, L. | 登録日 | 2013-09-15 | 公開日 | 2013-12-11 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Pyrido[2,3-d]pyrimidines: Discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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6L8I
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6L8H
| Crystal structure of CYP97C1 | 分子名称: | Carotene epsilon-monooxygenase, chloroplastic, GLYCEROL, ... | 著者 | Niu, G, Guo, Q, Liu, L. | 登録日 | 2019-11-06 | 公開日 | 2020-06-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for plant lutein biosynthesis from alpha-carotene. Proc.Natl.Acad.Sci.USA, 117, 2020
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