8Y8A

Structure of HCoV-HKU1C spike in the functionally anchored-3up conformation with 3TMPRSS2

Summary for 8Y8A

Entry DOI	10.2210/pdb8y8a/pdb
EMDB information	39039
Descriptor	Transmembrane protease serine 2, Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	hku1c, spike, tmprss2, viral protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	555631.82
Authors	Lu, Y.C.,Zhang, X.,Wang, H.F.,Liu, X.C.,Sun, L.,Yang, H.T. (deposition date: 2024-02-06, release date: 2024-07-17)
Primary citation	Wang, H.,Liu, X.,Zhang, X.,Zhao, Z.,Lu, Y.,Pu, D.,Zhang, Z.,Chen, J.,Wang, Y.,Li, M.,Dong, X.,Duan, Y.,He, Y.,Mao, Q.,Guo, H.,Sun, H.,Zhou, Y.,Yang, Q.,Gao, Y.,Yang, X.,Cao, H.,Guddat, L.,Sun, L.,Rao, Z.,Yang, H. TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry. Cell, 2024 Cited by PubMed: 38964329 DOI: 10.1016/j.cell.2024.06.016 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.19 Å)

Structure validation