8Y8A
Structure of HCoV-HKU1C spike in the functionally anchored-3up conformation with 3TMPRSS2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, F (T, H, G) | Transmembrane protease serine 2 | polymer | 383 | 42283.6 | 3 | UniProt (O15393) Pfam (PF15494) Pfam (PF00089) | Homo sapiens (human) | |
| 2 | C, D, E (A, C, B) | Spike glycoprotein | polymer | 1263 | 140242.5 | 3 | UniProt (Q0ZME7) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) | Human coronavirus HKU1 (isolate N5) (HCoV-HKU1) | S glycoprotein,E2,Peplomer protein |
| 3 | G, H, I, K, M... (D, E, F, J, L...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 11 | In PDB GlyTouCan (G42666HT) | |||
| 4 | J, L (I, K) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 5 | AA, BA, CA, T, U... (B, A, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 10 | Chemie (NAG) |
Sequence modifications
T, H, G: 110 - 492 (UniProt: O15393)
A, C, B: 14 - 1276 (UniProt: Q0ZME7)
| PDB | External Database | Details |
|---|---|---|
| Asp 251 | Ser 250 | engineered mutation |
| Asp 252 | Ser 251 | engineered mutation |
| - | Arg 252 | deletion |
| Asp 253 | Gln 253 | engineered mutation |
| Asp 254 | Ser 254 | engineered mutation |
| Lys 255 | Arg 255 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 752 | Arg 752 | engineered mutation |
| Gly 753 | Arg 753 | engineered mutation |
| Ser 754 | Lys 754 | engineered mutation |
| Gly 755 | Arg 755 | engineered mutation |
| Ser 756 | Arg 756 | engineered mutation |
| Pro 902 | Leu 902 | engineered mutation |
| Pro 980 | Ser 980 | engineered mutation |
| Pro 1023 | Asn 1023 | engineered mutation |
| Pro 1067 | Asn 1067 | engineered mutation |
| Pro 1068 | Leu 1068 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 547578.2 | |
| Branched | Number of molecules | 13 |
| Total formula weight | 5841.5 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2212.1 | |
| All* | Total formula weight | 555631.8 |
