8Y7Y

Local structure of HCoV-HKU1A spike in complex with TMPRSS2 and glycan

Summary for 8Y7Y

Entry DOI	10.2210/pdb8y7y/pdb
EMDB information	39026
Descriptor	Spike glycoprotein, Transmembrane protease serine 2, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	hku1a, spike, tmprss2, viral protein
Biological source	Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) More
Total number of polymer chains	3
Total formula weight	330372.50
Authors	Wang, H.F.,Zhang, X.,Lu, Y.,Liu, X.,Sun, L.,Yang, H.T. (deposition date: 2024-02-05, release date: 2024-07-17, Last modification date: 2024-08-28)
Primary citation	Wang, H.,Liu, X.,Zhang, X.,Zhao, Z.,Lu, Y.,Pu, D.,Zhang, Z.,Chen, J.,Wang, Y.,Li, M.,Dong, X.,Duan, Y.,He, Y.,Mao, Q.,Guo, H.,Sun, H.,Zhou, Y.,Yang, Q.,Gao, Y.,Yang, X.,Cao, H.,Guddat, L.,Sun, L.,Rao, Z.,Yang, H. TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry. Cell, 187:4261-, 2024 Cited by PubMed: 38964329 DOI: 10.1016/j.cell.2024.06.016 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.24 Å)

Structure validation