8HCI
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8HI8
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8HI7
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8W6A
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8W6B
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8X8A
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8X8K
| Crystal structure of STBD1 CBM20 domain in complex with maltotetraose | 分子名称: | GLYCEROL, Starch-binding domain-containing protein 1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Zhang, Y.C, Pan, L.F. | 登録日 | 2023-11-27 | 公開日 | 2024-09-18 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Decoding the molecular mechanism of selective autophagy of glycogen mediated by autophagy receptor STBD1. Proc.Natl.Acad.Sci.USA, 121, 2024
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5ZBG
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5TZC
| Crystal Structure of human PDE2a in complex with (5S)-1-[(3-bromo-4-fluorophenyl)carbonyl]-3,3-difluoro-5-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperidine | 分子名称: | (3-bromo-4-fluorophenyl)[(5S)-3,3-difluoro-5-(5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone, MAGNESIUM ION, ZINC ION, ... | 著者 | Xu, R, Aertgeerts, K. | 登録日 | 2016-11-21 | 公開日 | 2017-02-22 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | 主引用文献 | Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders. J. Med. Chem., 60, 2017
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5TZH
| CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 2A IN COMPLEX WITH 3,3-difluoro-1-[(4-fluorophenyl)carbonyl]-5-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}piperidine | 分子名称: | MAGNESIUM ION, ZINC ION, [(5S)-3,3-difluoro-5-(5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl](4-fluorophenyl)methanone, ... | 著者 | Xu, R, Aertgeerts, K. | 登録日 | 2016-11-21 | 公開日 | 2017-02-22 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders. J. Med. Chem., 60, 2017
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7BOK
| Cryo-EM structure of the encapsulated DyP-type peroxidase from Mycobacterium smegmatis | 分子名称: | Dyp-type peroxidase, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Tang, Y.T, Mu, A, Gong, H.R, Wang, Q, Rao, Z.H. | 登録日 | 2020-03-19 | 公開日 | 2021-03-24 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Cryo-EM structure of Mycobacterium smegmatis DyP-loaded encapsulin. Proc.Natl.Acad.Sci.USA, 118, 2021
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7BOJ
| Cryo-EM structure of the encapsulin shell from Mycobacterium smegmatis | 分子名称: | 29 kDa antigen Cfp29 | 著者 | Tang, Y.T, Mu, A, Gong, H.R, Wang, Q, Rao, Z.H. | 登録日 | 2020-03-19 | 公開日 | 2021-03-24 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Cryo-EM structure of Mycobacterium smegmatis DyP-loaded encapsulin. Proc.Natl.Acad.Sci.USA, 118, 2021
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7V6Z
| Cryo-EM structure of Patched1 (V1084A mutant) in lipid nanodisc, 3.64 angstrom (reprocessed with the dataset of 7dzp) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | 著者 | Luo, Y, Zhao, Y, Qu, Q, Li, D. | 登録日 | 2021-08-20 | 公開日 | 2021-09-22 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | 主引用文献 | Cryo-EM study of patched in lipid nanodisc suggests a structural basis for its clustering in caveolae. Structure, 29, 2021
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7V6Y
| Cryo-EM structure of Patched in lipid nanodisc - the wildtype, 3.5 angstrom (re-processed with dataset of 7dzq) | 分子名称: | (2S)-2-azanyl-3-[[(2S)-3-butanoyloxy-2-dec-9-enoyloxy-propoxy]-oxidanyl-phosphoryl]oxy-propanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Luo, Y, Zhao, Y, Qu, Q, Li, D. | 登録日 | 2021-08-20 | 公開日 | 2021-09-22 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Cryo-EM study of patched in lipid nanodisc suggests a structural basis for its clustering in caveolae. Structure, 29, 2021
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8K6P
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8K6Q
| Crystal structure of HOIL-1L LTM domain | 分子名称: | RanBP-type and C3HC4-type zinc finger-containing protein 1 | 著者 | Yan, Z, Pan, L.F. | 登録日 | 2023-07-25 | 公開日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Mechanistic insights into the homo-dimerization of HOIL-1L and SHARPIN. Biochem.Biophys.Res.Commun., 689, 2023
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8J03
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7DUU
| Crystal structure of HLA molecule with an KIR receptor | 分子名称: | Beta-2-microglobulin, Killer cell immunoglobulin-like receptor 2DS2, LEU-ASN-PRO-SER-VAL-ALA-ALA-THR-LEU, ... | 著者 | Yang, Y, Yin, L. | 登録日 | 2021-01-11 | 公開日 | 2022-02-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Activating receptor KIR2DS2 bound to HLA-C1 reveals the novel recognition features of activating receptor. Immunology, 165, 2022
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5X5L
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5X5J
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5XJP
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8HUR
| Crystal structure of SARS-Cov-2 main protease in complex with S217622 | 分子名称: | 3C-like proteinase nsp5, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione | 著者 | Zhou, X.L, Zhang, J, Li, J. | 登録日 | 2022-12-24 | 公開日 | 2023-06-21 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Structural basis for the inhibition of coronaviral main proteases by ensitrelvir. Structure, 31, 2023
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7JG4
| Human GAR transformylase in complex with GAR substrate and AGF131 inhibitor | 分子名称: | GLYCINAMIDE RIBONUCLEOTIDE, N-(5-{3-[(1S,7R,8R,9S)-4-amino-2-oxo-7lambda~4~-thia-3,5-diazatetracyclo[4.3.0.0~1,7~.0~7,9~]nona-3,5-dien-8-yl]propyl}thiophene-2-carbonyl)-L-glutamic acid, SODIUM ION, ... | 著者 | Wong-Roushar, J, Dann III, C.E. | 登録日 | 2020-07-18 | 公開日 | 2021-03-31 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.455 Å) | 主引用文献 | Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors Bioorg.Med.Chem., 37, 2021
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7JG3
| Human GAR transformylase in complex with GAR substrate and AGF103 inhibitor | 分子名称: | GLYCINAMIDE RIBONUCLEOTIDE, N-{5-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]furan-2-carbonyl}-L-glutamic acid, SODIUM ION, ... | 著者 | Wong-Roushar, J, Dann III, C.E. | 登録日 | 2020-07-18 | 公開日 | 2021-03-31 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.091 Å) | 主引用文献 | Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors Bioorg.Med.Chem., 37, 2021
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7JG0
| Human GAR transformylase in complex with GAR substrate and AGF102 inhibitor | 分子名称: | GLYCINAMIDE RIBONUCLEOTIDE, N-{5-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]thiophene-2-carbonyl}-L-glutamic acid, Trifunctional purine biosynthetic protein adenosine-3 | 著者 | Wong-Roushar, J, Dann III, C.E. | 登録日 | 2020-07-18 | 公開日 | 2021-03-31 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.984 Å) | 主引用文献 | Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors Bioorg.Med.Chem., 37, 2021
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