6LTK

HSP90 in complex with SNX-2112

Summary for 6LTK

Entry DOI	10.2210/pdb6ltk/pdb
Descriptor	Heat shock protein HSP 90-alpha, 4-[6,6-dimethyl-4-oxidanylidene-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]-2-[(4-oxidanylcyclohexyl)amino]benzamide (3 entities in total)
Functional Keywords	hsp90, snx-2112, chaperone
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	28865.18
Authors	Cao, H.L. (deposition date: 2020-01-22, release date: 2021-01-27, Last modification date: 2023-11-29)
Primary citation	Zhao, D.,Xu, Y.M.,Cao, L.Q.,Yu, F.,Zhou, H.,Qin, W.,Li, H.J.,He, C.X.,Xing, L.,Zhou, X.,Li, P.Q.,Jin, X.,He, Y.,He, J.H.,Cao, H.L. Complex Crystal Structure Determination and in vitro Anti-non-small Cell Lung Cancer Activity of Hsp90 N Inhibitor SNX-2112. Front Cell Dev Biol, 9:650106-650106, 2021 Cited by PubMed: 33855025 DOI: 10.3389/fcell.2021.650106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.141 Å)

Structure validation