8GOU
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![BU of 8gou by Molmil](/molmil-images/mine/8gou) | Omicron BA.4/5 SARS-CoV-2 S in complex with TH003 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, TH003 Fab heavy chain, ... | 著者 | Guo, Y, Zhang, G, Liang, J, Liu, F, Rao, Z. | 登録日 | 2022-08-25 | 公開日 | 2023-06-28 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection. Nat Commun, 14, 2023
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8GPY
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![BU of 8gpy by Molmil](/molmil-images/mine/8gpy) | Crystal structure of Omicron BA.4/5 RBD in complex with a neutralizing antibody scFv | 分子名称: | Spike protein S1, scFv | 著者 | Gao, Y.X, Song, Z.D, Wang, W.M, Guo, Y. | 登録日 | 2022-08-27 | 公開日 | 2023-06-28 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection. Nat Commun, 14, 2023
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3COH
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![BU of 3coh by Molmil](/molmil-images/mine/3coh) | Crystal structure of Aurora-A in complex with a pentacyclic inhibitor | 分子名称: | 8-ethyl-3,10,10-trimethyl-4,5,6,8,10,12-hexahydropyrazolo[4',3':6,7]cyclohepta[1,2-b]pyrrolo[2,3-f]indol-9(1H)-one, Serine/threonine-protein kinase 6 | 著者 | Wiesmann, C, Raswson, T.E, Cochran, A.G. | 登録日 | 2008-03-28 | 公開日 | 2009-02-17 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability. J.Med.Chem., 51, 2008
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6XLU
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![BU of 6xlu by Molmil](/molmil-images/mine/6xlu) | Structure of SARS-CoV-2 spike at pH 4.0 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Zhou, T, Tsybovsky, Y, Olia, A, Kwong, P.D. | 登録日 | 2020-06-29 | 公開日 | 2020-08-12 | 最終更新日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020
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6XM3
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![BU of 6xm3 by Molmil](/molmil-images/mine/6xm3) | Structure of SARS-CoV-2 spike at pH 5.5, single RBD up, conformation 1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Zhou, T, Tsybovsky, Y, Olia, A, Kwong, P.D. | 登録日 | 2020-06-29 | 公開日 | 2020-08-12 | 最終更新日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020
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8H77
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![BU of 8h77 by Molmil](/molmil-images/mine/8h77) | Hsp90-AhR-p23-XAP2 complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, AH receptor-interacting protein, Aryl hydrocarbon receptor, ... | 著者 | Wen, Z.L, Zhai, Y.J, Zhu, Y, Sun, F. | 登録日 | 2022-10-19 | 公開日 | 2023-01-04 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structure of the cytosolic AhR complex. Structure, 31, 2023
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6CDI
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![BU of 6cdi by Molmil](/molmil-images/mine/6cdi) | Cryo-EM structure at 3.6 A resolution of vaccine-elicited antibody vFP16.02 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein 120, ... | 著者 | Acharya, P, Xu, K, Liu, K, Carragher, B, Potter, C.S, Kwong, P.D. | 登録日 | 2018-02-08 | 公開日 | 2018-05-16 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1. Nat. Med., 24, 2018
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7BTF
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![BU of 7btf by Molmil](/molmil-images/mine/7btf) | SARS-CoV-2 RNA-dependent RNA polymerase in complex with cofactors in reduced condition | 分子名称: | Non-structural protein 7, Non-structural protein 8, RNA-directed RNA polymerase, ... | 著者 | Gao, Y, Yan, L, Huang, Y, Liu, F, Cao, L, Wang, T, Wang, Q, Lou, Z, Rao, Z. | 登録日 | 2020-04-01 | 公開日 | 2020-04-08 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Science, 368, 2020
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6CDE
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![BU of 6cde by Molmil](/molmil-images/mine/6cde) | Cryo-EM structure at 3.8 A resolution of vaccine-elicited antibody vFP20.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein 120, ... | 著者 | Acharya, P, Xu, K, Liu, K, Carragher, B, Potter, C.S, Kwong, P.D. | 登録日 | 2018-02-08 | 公開日 | 2018-05-16 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1. Nat. Med., 24, 2018
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6XM5
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![BU of 6xm5 by Molmil](/molmil-images/mine/6xm5) | Structure of SARS-CoV-2 spike at pH 5.5, all RBDs down | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Zhou, T, Tsybovsky, Y, Olia, A, Kwong, P.D. | 登録日 | 2020-06-29 | 公開日 | 2020-07-29 | 最終更新日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020
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6XM4
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![BU of 6xm4 by Molmil](/molmil-images/mine/6xm4) | Structure of SARS-CoV-2 spike at pH 5.5, single RBD up, conformation 2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Zhou, T, Tsybovsky, Y, Olia, A, Kwong, P.D. | 登録日 | 2020-06-29 | 公開日 | 2020-08-12 | 最終更新日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020
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6CUE
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![BU of 6cue by Molmil](/molmil-images/mine/6cue) | Cryo-EM structure at 4.0 A resolution of vaccine-elicited antibody vFP7.04 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | 著者 | Acharya, P, Carragher, B, Potter, C.S, Kwong, P.D. | 登録日 | 2018-03-26 | 公開日 | 2018-07-11 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV. PLoS Pathog., 14, 2018
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6XM0
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![BU of 6xm0 by Molmil](/molmil-images/mine/6xm0) | Consensus structure of SARS-CoV-2 spike at pH 5.5 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Zhou, T, Tsybovsky, Y, Olia, A, Kwong, P.D. | 登録日 | 2020-06-29 | 公開日 | 2020-08-12 | 最終更新日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains. Cell Host Microbe, 28, 2020
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6CUF
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![BU of 6cuf by Molmil](/molmil-images/mine/6cuf) | Cryo-EM structure at 4.2 A resolution of vaccine-elicited antibody vFP1.01 in complex with HIV-1 Env BG505 DS-SOSIP, and antibodies VRC03 and PGT122 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | 著者 | Acharya, P, Carragher, B, Potter, C.S, Kwong, P.D. | 登録日 | 2018-03-26 | 公開日 | 2018-07-25 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV. PLoS Pathog., 14, 2018
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3H0Z
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![BU of 3h0z by Molmil](/molmil-images/mine/3h0z) | Aurora A in complex with a bisanilinopyrimidine | 分子名称: | 4-{[2-({4-[2-(4-acetylpiperazin-1-yl)-2-oxoethyl]phenyl}amino)-5-fluoropyrimidin-4-yl]amino}-N-(2-chlorophenyl)benzamide, Serine/threonine-protein kinase 6 | 著者 | Wiesmann, C, Ultsch, M.H, Cochran, A.G. | 登録日 | 2009-04-10 | 公開日 | 2009-07-07 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | 主引用文献 | A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. J.Med.Chem., 52, 2009
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6M71
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![BU of 6m71 by Molmil](/molmil-images/mine/6m71) | SARS-Cov-2 RNA-dependent RNA polymerase in complex with cofactors | 分子名称: | Non-structural protein 7, Non-structural protein 8, RNA-directed RNA polymerase | 著者 | Gao, Y, Yan, L, Huang, Y, Liu, F, Cao, L, Wang, T, Wang, Q, Lou, Z, Rao, Z. | 登録日 | 2020-03-16 | 公開日 | 2020-04-01 | 最終更新日 | 2021-03-10 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Science, 368, 2020
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3H10
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![BU of 3h10 by Molmil](/molmil-images/mine/3h10) | Aurora A inhibitor complex | 分子名称: | 9-chloro-7-(2,6-difluorophenyl)-N-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-5H-pyrimido[5,4-d][2]benzazepin-2-amine, Serine/threonine-protein kinase 6 | 著者 | Wiesmann, C, Ultsch, M.H, Cochran, A.G. | 登録日 | 2009-04-10 | 公開日 | 2009-07-07 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. J.Med.Chem., 52, 2009
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4XMP
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![BU of 4xmp by Molmil](/molmil-images/mine/4xmp) | Crystal structure of broadly and potently neutralizing antibody VRC08 in complex with HIV-1 clade A strain Q842.d12 gp120 | 分子名称: | (R,R)-2,3-BUTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160,Envelope glycoprotein gp160,Envelope glycoprotein gp160, ... | 著者 | Zhou, T, Srivatsan, S, Kwong, P.D. | 登録日 | 2015-01-15 | 公開日 | 2015-04-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.7831 Å) | 主引用文献 | Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection. Cell, 161, 2015
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3H0Y
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![BU of 3h0y by Molmil](/molmil-images/mine/3h0y) | Aurora A in complex with a bisanilinopyrimidine | 分子名称: | 2-chloro-N-[4-({5-fluoro-2-[(4-hydroxyphenyl)amino]pyrimidin-4-yl}amino)phenyl]benzamide, SULFATE ION, Serine/threonine-protein kinase 6 | 著者 | Wiesmann, C, Ultsch, M.H, Cochran, A.G. | 登録日 | 2009-04-10 | 公開日 | 2009-07-07 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. J.Med.Chem., 52, 2009
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6LZZ
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![BU of 6lzz by Molmil](/molmil-images/mine/6lzz) | Crystal structure of the PDE9 catalytic domain in complex with inhibitor 4a | 分子名称: | 1-cyclopentyl-6-[[(2R)-1-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-1-oxidanylidene-propan-2-yl]amino]-5H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... | 著者 | Huang, Y.Y, Wu, Y, Luo, H.B. | 登録日 | 2020-02-19 | 公開日 | 2021-02-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.40003753 Å) | 主引用文献 | Identification of phosphodiesterase-9 as a novel target for pulmonary arterial hypertension by using highly selective and orally bioavailable inhibitors To Be Published
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4XVS
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![BU of 4xvs by Molmil](/molmil-images/mine/4xvs) | Crystal structure of HIV-1 donor 45 d45-01dG5 coreE gp120 with antibody 45-VRC01.H01+07.O-863513/45-VRC01.L01+07.O-110653 (VRC07_1995) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 45-VRC01.H01+07.O-863513/45-VRC01.L01+07.O-110653 Light chain, Donor 45 01dG5 coreE gp120, ... | 著者 | Joyce, M.G, Mascola, J.R, Kwong, P.D. | 登録日 | 2015-01-27 | 公開日 | 2015-05-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection. Cell, 161, 2015
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4XNZ
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![BU of 4xnz by Molmil](/molmil-images/mine/4xnz) | Crystal structure of broadly and potently neutralizing antibody VRC06B in complex with HIV-1 clade A/E strain 93TH057 gp120 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160,Envelope glycoprotein gp160, ... | 著者 | Zhou, T, Srivatsan, S, Kwong, P.D. | 登録日 | 2015-01-16 | 公開日 | 2015-04-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.389 Å) | 主引用文献 | Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection. Cell, 161, 2015
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4XNY
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![BU of 4xny by Molmil](/molmil-images/mine/4xny) | Crystal structure of broadly and potently neutralizing antibody VRC08C in complex with HIV-1 clade A strain Q842.d12 gp120 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160,Envelope glycoprotein gp160,Envelope glycoprotein gp160, HEAVY CHAIN OF ANTIBODY VRC08C, ... | 著者 | Zhou, T, Srivatsan, S, Kwong, P.D. | 登録日 | 2015-01-16 | 公開日 | 2015-04-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection. Cell, 161, 2015
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4XVT
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![BU of 4xvt by Molmil](/molmil-images/mine/4xvt) | Crystal structure of HIV-1 93TH057 coreE gp120 with antibody 45-VRC01.H01+07.O-863513/45-VRC01.L01+07.O-110653 (VRC07_1995) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 45-VRC01.H01+07.O-863513/45-VRC01.L01+07.O-110653 (VRC07_1995) Light chain, ENVELOPE GLYCOPROTEIN GP120 OF HIV-1 CLADE A/E, ... | 著者 | Joyce, M.G, Mascola, J.R, Kwong, P.D. | 登録日 | 2015-01-28 | 公開日 | 2015-07-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection. Cell, 161, 2015
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7BXU
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![BU of 7bxu by Molmil](/molmil-images/mine/7bxu) | CLC-7/Ostm1 membrane protein complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, H(+)/Cl(-) exchange transporter 7, Osteopetrosis-associated transmembrane protein 1 | 著者 | Zhang, S.S, Yang, M.J. | 登録日 | 2020-04-20 | 公開日 | 2020-09-16 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Molecular insights into the human CLC-7/Ostm1 transporter. Sci Adv, 6, 2020
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