4XNY

Crystal structure of broadly and potently neutralizing antibody VRC08C in complex with HIV-1 clade A strain Q842.d12 gp120

Summary for 4XNY

• Entry DOI: 10.2210/pdb4xny/pdb
• Related: 3NGB 4XMP 4XNZ
• Descriptor: Envelope glycoprotein gp160,Envelope glycoprotein gp160,Envelope glycoprotein gp160, HEAVY CHAIN OF ANTIBODY VRC08C, LIGHT CHAIN OF ANTIBODY VRC08C, ... (5 entities in total)
• Functional Keywords: antibody, hiv-1, immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 3
• Total formula weight: 90325.04

Authors

Zhou, T.,Srivatsan, S.,Kwong, P.D. (deposition date: 2015-01-16, release date: 2015-04-29, Last modification date: 2023-09-27)

• Primary citation: Wu, X.,Zhang, Z.,Schramm, C.A.,Joyce, M.G.,Do Kwon, Y.,Zhou, T.,Sheng, Z.,Zhang, B.,O'Dell, S.,McKee, K.,Georgiev, I.S.,Chuang, G.Y.,Longo, N.S.,Lynch, R.M.,Saunders, K.O.,Soto, C.,Srivatsan, S.,Yang, Y.,Bailer, R.T.,Louder, M.K.,Mullikin, J.C.,Connors, M.,Kwong, P.D.,Mascola, J.R.,Shapiro, L.; Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection.; Cell, 161:470-485, 2015; PubMed: 25865483; DOI: 10.1016/j.cell.2015.03.004

Experimental method

X-RAY DIFFRACTION (2.3 Å)