4XNY

Crystal structure of broadly and potently neutralizing antibody VRC08C in complex with HIV-1 clade A strain Q842.d12 gp120

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (G)	Envelope glycoprotein gp160,Envelope glycoprotein gp160,Envelope glycoprotein gp160	polymer	354	39667.8	1	UniProt (Q8JDI3) Pfam (PF00516)	Human immunodeficiency virus 1
2	B (H)	HEAVY CHAIN OF ANTIBODY VRC08C	polymer	235	25296.4	1	Pfam (PF07654) UniProt (by SIFTS) (P01857)	Homo sapiens (Human)
3	C (L)	LIGHT CHAIN OF ANTIBODY VRC08C	polymer	211	22927.5	1	Pfam (PF07654) UniProt (by SIFTS) (P01834)	Homo sapiens (Human)
4	D, E, F, G, H... (G)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	11	Chemie (NAG)
5	O, P, Q (G, H, L)	water	water		18.0	205	Chemie (HOH)

Sequence modifications

G: 44 - 123 (UniProt: Q8JDI3)
G: 199 - 317 (UniProt: Q8JDI3)

PDB	External Database	Details
Gly 124	-	linker
Gly 198	-	linker

G: 324 - 492 (UniProt: Q8JDI3)

PDB	External Database	Details
Gly 318	-	linker
Gly 319	-	linker
Ser 320	-	linker
Gly 321	-	linker
Ser 322	-	linker
Gly 323	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	87891.8
Non-Polymers*	Number of molecules	11
	Total formula weight	2433.3
All*	Total formula weight	90325.0

*Water molecules are not included.