8XFB
| Cryo-EM structure of partial dimeric WDR11-FAM91A1 complex | 分子名称: | Protein FAM91A1, WD repeat-containing protein 11 | 著者 | Jia, G.W, Deng, Q.H, Su, Z.M, Jia, D. | 登録日 | 2023-12-13 | 公開日 | 2024-08-14 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | The WDR11 complex is a receptor for acidic-cluster-containing cargo proteins. Cell, 187, 2024
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6K12
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6J9D
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9EQF
| Crystal structure of the L-arginine hydroxylase VioC MeHis316, bound to Fe(II), L-arginine, and succinate | 分子名称: | 1,2-ETHANEDIOL, ARGININE, Alpha-ketoglutarate-dependent L-arginine hydroxylase, ... | 著者 | Hardy, F.J. | 登録日 | 2024-03-21 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-21 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Probing Ferryl Reactivity in a Nonheme Iron Oxygenase Using an Expanded Genetic Code. Acs Catalysis, 14, 2024
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6L7P
| cryo-EM structure of cyanobacteria NDH-1LdelV complex | 分子名称: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, BETA-CAROTENE, ... | 著者 | Zhang, C, Shuai, J, Wu, J, Lei, M. | 登録日 | 2019-11-02 | 公開日 | 2020-02-19 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural insights into NDH-1 mediated cyclic electron transfer. Nat Commun, 11, 2020
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1R9H
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3H2L
| Crystal structure of HCV NS5B polymerase in complex with a novel bicyclic dihydro-pyridinone inhibitor | 分子名称: | N-{3-[(4aR,7aS)-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-2,4a,5,6,7,7a-hexahydro-1H-cyclopenta[b]pyridin-3-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, NS5B polymerase | 著者 | Han, Q, Showalter, R.E, Zhou, Q, Kissinger, C.R. | 登録日 | 2009-04-14 | 公開日 | 2009-12-08 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase. Bioorg.Med.Chem.Lett., 19, 2009
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8JYS
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5Y2F
| Human SIRT6 in complex with allosteric activator MDL-801 | 分子名称: | 5-[[3,5-bis(chloranyl)phenyl]sulfonylamino]-2-[(5-bromanyl-4-fluoranyl-2-methyl-phenyl)sulfamoyl]benzoic acid, 9-mer peptide QTARKSTGG, DI(HYDROXYETHYL)ETHER, ... | 著者 | Zhang, J, Huang, Z, Song, K. | 登録日 | 2017-07-25 | 公開日 | 2018-11-07 | 最終更新日 | 2018-11-28 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Identification of a cellularly active SIRT6 allosteric activator. Nat. Chem. Biol., 14, 2018
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7BZG
| Structure of Bacillus subtilis HxlR, wild type in complex with formaldehyde and DNA | 分子名称: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*CP*AP*GP*TP*AP*TP*CP*CP*TP*CP*GP*AP*GP*GP*AP*TP*AP*CP*TP*G)-3'), ... | 著者 | Zhu, R, Chen, P.R. | 登録日 | 2020-04-27 | 公開日 | 2021-02-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Genetically encoded formaldehyde sensors inspired by a protein intra-helical crosslinking reaction. Nat Commun, 12, 2021
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7BZD
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7BZE
| Structure of Bacillus subtilis HxlR, K13A mutant | 分子名称: | DI(HYDROXYETHYL)ETHER, HTH-type transcriptional activator HxlR | 著者 | Zhu, R, Chen, P.R. | 登録日 | 2020-04-27 | 公開日 | 2021-02-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.658 Å) | 主引用文献 | Genetically encoded formaldehyde sensors inspired by a protein intra-helical crosslinking reaction. Nat Commun, 12, 2021
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7BW4
| Structure of the RNA-dependent RNA polymerase from SARS-CoV-2 | 分子名称: | Non-structural protein 7, Non-structural protein 8, RNA-directed RNA polymerase, ... | 著者 | Peng, Q, Peng, R, Shi, Y. | 登録日 | 2020-04-13 | 公開日 | 2020-05-27 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2. Cell Rep, 31, 2020
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6C10
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5DRO
| Structure of the Aquifex aeolicus LpxC/LPC-011 Complex | 分子名称: | 4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]benzamide, ACETATE ION, DIMETHYL SULFOXIDE, ... | 著者 | Lee, C.-J, Najeeb, J, Zhou, P. | 登録日 | 2015-09-16 | 公開日 | 2016-03-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Drug design from the cryptic inhibitor envelope. Nat Commun, 7, 2016
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5DRP
| Structure of the AaLpxC/LPC-023 Complex | 分子名称: | CHLORIDE ION, DIMETHYL SULFOXIDE, N~2~-{4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]benzoyl}-N-hydroxy-L-isoleucinamide, ... | 著者 | Najeeb, J, Lee, C.-J, Zhou, P. | 登録日 | 2015-09-16 | 公開日 | 2016-03-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.889 Å) | 主引用文献 | Drug design from the cryptic inhibitor envelope. Nat Commun, 7, 2016
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5DRR
| Crystal structure of the Pseudomonas aeruginosa LpxC/LPC-058 complex | 分子名称: | 4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3S)-4,4-difluoro-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]benzamide, NITRATE ION, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ... | 著者 | Lee, C.-J, Najeeb, J, Zhou, P. | 登録日 | 2015-09-16 | 公開日 | 2016-03-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Drug design from the cryptic inhibitor envelope. Nat Commun, 7, 2016
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6C13
| CryoEM structure of mouse PCDH15-4EC-LHFPL5 complex | 分子名称: | Protocadherin-15, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Gouaux, E, Ge, J, Elferich, J. | 登録日 | 2018-01-03 | 公開日 | 2018-08-15 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (11.33 Å) | 主引用文献 | Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5. Elife, 7, 2018
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6C14
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5VXA
| Structure of the human Mesh1-NADPH complex | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BETA-MERCAPTOETHANOL, ... | 著者 | Rose, J, Zhou, P. | 登録日 | 2017-05-23 | 公開日 | 2018-05-23 | 最終更新日 | 2022-03-30 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis. Nat Metab, 2, 2020
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5DRQ
| Crystal structure of the Pseudomonas aeruginosa LpxC/LPC-040 complex | 分子名称: | N-[(2S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]benzamide, NITRATE ION, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ... | 著者 | Lee, C.-J, Najeeb, J, Zhou, P. | 登録日 | 2015-09-16 | 公開日 | 2016-03-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Drug design from the cryptic inhibitor envelope. Nat Commun, 7, 2016
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7Y7P
| QDE-1 in complex with RNA template, RNA primer and AMPNPP | 分子名称: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Cui, R.X, Gan, J.H, Ma, J.B. | 登録日 | 2022-06-22 | 公開日 | 2022-09-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1. Nucleic Acids Res., 50, 2022
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7Y7Q
| QDE-1 in complex with RNA template, RNA primer and 3'-dGTP | 分子名称: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Cui, R.X, Gan, J.H, Ma, J.B. | 登録日 | 2022-06-22 | 公開日 | 2022-09-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1. Nucleic Acids Res., 50, 2022
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7Y7R
| QDE-1 in complex with DNA template, RNA primer and 3'-dGTP | 分子名称: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*GP*AP*AP*CP*TP*AP*CP*CP*GP*TP*CP*GP*GP*A)-3'), ... | 著者 | Cui, R.X, Gan, J.H, Ma, J.B. | 登録日 | 2022-06-22 | 公開日 | 2022-09-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1. Nucleic Acids Res., 50, 2022
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7Y7S
| QDE-1 in complex with DNA template, RNA primer and AMPNPP | 分子名称: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Cui, R.X, Gan, J.H, Ma, J.B. | 登録日 | 2022-06-22 | 公開日 | 2022-09-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1. Nucleic Acids Res., 50, 2022
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