5DRQ
Crystal structure of the Pseudomonas aeruginosa LpxC/LPC-040 complex
Summary for 5DRQ
| Entry DOI | 10.2210/pdb5drq/pdb |
| Related | 5DRO 5DRP 5DRR |
| Descriptor | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, N-[(2S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]benzamide, ... (5 entities in total) |
| Functional Keywords | lpxc, lipid a, inhibitor, gram-negative bacteria, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) |
| Total number of polymer chains | 1 |
| Total formula weight | 35466.01 |
| Authors | Lee, C.-J.,Najeeb, J.,Zhou, P. (deposition date: 2015-09-16, release date: 2016-03-09, Last modification date: 2023-09-27) |
| Primary citation | Lee, C.J.,Liang, X.,Wu, Q.,Najeeb, J.,Zhao, J.,Gopalaswamy, R.,Titecat, M.,Sebbane, F.,Lemaitre, N.,Toone, E.J.,Zhou, P. Drug design from the cryptic inhibitor envelope. Nat Commun, 7:10638-10638, 2016 Cited by PubMed: 26912110DOI: 10.1038/ncomms10638 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.63 Å) |
Structure validation
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