Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5DRQ

Crystal structure of the Pseudomonas aeruginosa LpxC/LPC-040 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006796	biological_process	phosphate-containing compound metabolic process
A	0008759	molecular_function	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A	0009245	biological_process	lipid A biosynthetic process
A	0016787	molecular_function	hydrolase activity
A	0019637	biological_process	organophosphate metabolic process
A	0046872	molecular_function	metal ion binding
A	0103117	molecular_function	UDP-3-O-acyl-N-acetylglucosamine deacetylase activity
A	1901135	biological_process	carbohydrate derivative metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 301

Chain	Residue
A	HIS78
A	HIS237
A	ASP241
A	5EM303

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 302

Chain	Residue
A	HIS162
A	GLU219
A	ASP277
A	ASP279

site_id	AC3
Number of Residues	22
Details	binding site for residue 5EM A 303

Chain	Residue
A	HIS78
A	PHE112
A	GLN115
A	THR190
A	PHE191
A	ILE197
A	ARG201
A	GLY209
A	SER210
A	VAL211
A	HIS237
A	ASP241
A	HIS264
A	ZN301
A	NO3304
A	NO3307
A	HOH461
A	HOH462
A	HOH476
A	HOH506
A	HOH579
A	GLU77

site_id	AC4
Number of Residues	9
Details	binding site for residue NO3 A 304

Chain	Residue
A	LYS238
A	GLY263
A	HIS264
A	5EM303
A	NO3307
A	HOH476
A	HOH478
A	HOH489
A	HOH510

site_id	AC5
Number of Residues	6
Details	binding site for residue NO3 A 305

Chain	Residue
A	VAL137
A	GLU138
A	GLN269
A	HOH413
A	HOH435
A	HOH566

site_id	AC6
Number of Residues	6
Details	binding site for residue NO3 A 306

Chain	Residue
A	MET194
A	ARG195
A	ASP218
A	GLU219
A	HOH430
A	HOH497

site_id	AC7
Number of Residues	7
Details	binding site for residue NO3 A 307

Chain	Residue
A	PHE160
A	PHE191
A	LYS238
A	5EM303
A	NO3304
A	HOH410
A	HOH453

site_id	AC8
Number of Residues	7
Details	binding site for residue NO3 A 308

Chain	Residue
A	LYS142
A	SER262
A	GLY263
A	HIS264
A	ALA265
A	LEU266
A	HOH429

site_id	AC9
Number of Residues	7
Details	binding site for residue NO3 A 309

Chain	Residue
A	ILE158
A	ASP159
A	PHE160
A	LYS261
A	HOH453
A	HOH460
A	HOH495

site_id	AD1
Number of Residues	8
Details	binding site for residue NO3 A 310

Chain	Residue
A	ARG189
A	SER202
A	GLN203
A	ASN204
A	ARG229
A	HOH458
A	HOH524
A	HOH570

site_id	AD2
Number of Residues	7
Details	binding site for residue NO3 A 311

Chain	Residue
A	GLY108
A	PRO109
A	PHE112
A	ARG201
A	HOH433
A	HOH456
A	HOH579

site_id	AD3
Number of Residues	6
Details	binding site for residue NO3 A 312

Chain	Residue
A	PHE176
A	SER177
A	PRO293
A	ILE294
A	SER295
A	HOH492

site_id	AD4
Number of Residues	9
Details	binding site for residue NO3 A 313

Chain	Residue
A	PHE234
A	VAL235
A	HOH423
A	ILE158
A	ARG168
A	THR169
A	GLN170
A	ASP232
A	GLU233

site_id	AD5
Number of Residues	7
Details	binding site for residue NO3 A 314

Chain	Residue
A	ASN9
A	SER116
A	ALA117
A	VAL222
A	LEU223
A	NO3315
A	HOH409

site_id	AD6
Number of Residues	9
Details	binding site for residue NO3 A 315

Chain	Residue
A	LYS8
A	ASN9
A	SER116
A	ALA117
A	GLY118
A	LEU223
A	GLU225
A	NO3314
A	HOH409

site_id	AD7
Number of Residues	8
Details	binding site for residue NO3 A 316

Chain	Residue
A	THR14
A	TYR25
A	ARG133
A	GLU134
A	PRO148
A	ARG195
A	HOH457
A	HOH513

site_id	AD8
Number of Residues	7
Details	binding site for residue NO3 A 317

Chain	Residue
A	TYR25
A	SER96
A	PRO148
A	PHE149
A	ASP150
A	HOH414
A	HOH464

site_id	AD9
Number of Residues	6
Details	binding site for residue NO3 A 318

Chain	Residue
A	ILE10
A	ARG12
A	LYS29
A	ARG143
A	ARG258
A	PHE260

site_id	AE1
Number of Residues	4
Details	binding site for residue NO3 A 319

Chain	Residue
A	TYR230
A	GLU231
A	ASP232
A	LYS236

site_id	AE2
Number of Residues	4
Details	binding site for residue NO3 A 320

Chain	Residue
A	HIS19
A	MET62
A	LEU205
A	ALA206

site_id	AE3
Number of Residues	7
Details	binding site for residue NO3 A 321

Chain	Residue
A	GLU59
A	THR60
A	THR61
A	MET62
A	SER63
A	HOH406
A	HOH434

site_id	AE4
Number of Residues	4
Details	binding site for residue NO3 A 322

Chain	Residue
A	ARG166
A	GLN269
A	ARG272
A	THR273

site_id	AE5
Number of Residues	6
Details	binding site for residue NO3 A 323

Chain	Residue
A	THR285
A	PHE286
A	GLU287
A	ASP288
A	THR291
A	HOH438

site_id	AE6
Number of Residues	3
Details	binding site for residue NO3 A 324

Chain	Residue
A	LYS23
A	LYS132
A	ARG133

site_id	AE7
Number of Residues	5
Details	binding site for residue NO3 A 325

Chain	Residue
A	MET1
A	ALA125
A	THR285
A	PHE286
A	GLU287

site_id	AE8
Number of Residues	2
Details	binding site for residue NO3 A 326

Chain	Residue
A	VAL284
A	THR285

site_id	AE9
Number of Residues	4
Details	binding site for residue NO3 A 327

Chain	Residue
A	ARG41
A	ASP70
A	VAL71
A	LYS72

site_id	AF1
Number of Residues	7
Details	binding site for residue NO3 A 328

Chain	Residue
A	ARG53
A	ALA54
A	GLU55
A	LEU248
A	LEU249
A	ILE275
A	HOH571

site_id	AF2
Number of Residues	5
Details	binding site for residue NO3 A 329

Chain	Residue
A	GLU59
A	THR60
A	THR61
A	HOH428
A	HOH535

site_id	AF3
Number of Residues	5
Details	binding site for residue NO3 A 330

Chain	Residue
A	ARG168
A	VAL222
A	GLY227
A	LEU228
A	HOH402

site_id	AF4
Number of Residues	3
Details	binding site for residue NO3 A 331

Chain	Residue
A	LEU44
A	ASP45
A	HOH559

site_id	AF5
Number of Residues	6
Details	binding site for residue NO3 A 332

Chain	Residue
A	ASP159
A	PHE160
A	ASP161
A	HIS162
A	HOH436
A	HOH460

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000255\|HAMAP-Rule:MF_00388

Chain	Residue	Details
A	HIS264

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00388

Chain	Residue	Details
A	ASP241
A	HIS78
A	HIS237

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)