5DRO
Structure of the Aquifex aeolicus LpxC/LPC-011 Complex
Summary for 5DRO
Entry DOI | 10.2210/pdb5dro/pdb |
Related | 5DRP 5DRQ 5DRR |
Descriptor | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, 4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]benzamide, ... (6 entities in total) |
Functional Keywords | lpxc, inhibitor, lipid a, gram-negative bacteria, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Aquifex aeolicus (strain VF5) |
Total number of polymer chains | 2 |
Total formula weight | 63730.64 |
Authors | Lee, C.-J.,Najeeb, J.,Zhou, P. (deposition date: 2015-09-16, release date: 2016-03-09, Last modification date: 2023-09-27) |
Primary citation | Lee, C.J.,Liang, X.,Wu, Q.,Najeeb, J.,Zhao, J.,Gopalaswamy, R.,Titecat, M.,Sebbane, F.,Lemaitre, N.,Toone, E.J.,Zhou, P. Drug design from the cryptic inhibitor envelope. Nat Commun, 7:10638-10638, 2016 Cited by PubMed: 26912110DOI: 10.1038/ncomms10638 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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