2DDQ
 
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3B24
 | | Hsp90 alpha N-terminal domain in complex with an aminotriazine fragment molecule | | 分子名称: | 4-(ethylsulfanyl)-6-methyl-1,3,5-triazin-2-amine, Heat shock protein HSP 90-alpha, MAGNESIUM ION | | 著者 | Fukami, T.A, Ono, N. | | 登録日 | 2011-07-21 | | 公開日 | 2011-09-14 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design
Bioorg.Med.Chem.Lett., 21, 2011
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3B27
 | | Hsp90 alpha N-terminal domain in complex with an inhibitor Ro4919127 | | 分子名称: | 4-(2-chlorophenyl)-6-(methylsulfanyl)-1,3,5-triazin-2-amine, Heat shock protein HSP 90-alpha | | 著者 | Fukami, T.A, Ono, N. | | 登録日 | 2011-07-21 | | 公開日 | 2011-09-14 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design
Bioorg.Med.Chem.Lett., 21, 2011
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5YY9
 | | Crystal structure of Tandem Tudor Domain of human UHRF1 in complex with LIG1-K126me3 | | 分子名称: | E3 ubiquitin-protein ligase UHRF1, Ligase 1 | | 著者 | Kori, S, Defossez, P.A, Arita, K. | | 登録日 | 2017-12-08 | | 公開日 | 2018-12-12 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.653 Å) | | 主引用文献 | Structure of the UHRF1 Tandem Tudor Domain Bound to a Methylated Non-histone Protein, LIG1, Reveals Rules for Binding and Regulation.
Structure, 27, 2019
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5YYA
 | | Crystal structure of Tandem Tudor Domain of human UHRF1 | | 分子名称: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase UHRF1, SULFATE ION | | 著者 | Kori, S, Defossez, P.A, Arita, K. | | 登録日 | 2017-12-08 | | 公開日 | 2018-12-12 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structure of the UHRF1 Tandem Tudor Domain Bound to a Methylated Non-histone Protein, LIG1, Reveals Rules for Binding and Regulation.
Structure, 27, 2019
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3B25
 | | Hsp90 alpha N-terminal domain in complex with an inhibitor CH4675194 | | 分子名称: | 4-Methyl-6-(toluene-4-sulfonyl)-pyrimidin-2-ylamine, Heat shock protein HSP 90-alpha | | 著者 | Fukami, T.A, Ono, N. | | 登録日 | 2011-07-21 | | 公開日 | 2011-09-14 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design
Bioorg.Med.Chem.Lett., 21, 2011
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3B28
 | | Hsp90 alpha N-terminal domain in complex with an inhibitor CH5015765 | | 分子名称: | 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(methylsulfanyl)-1,3,5-triazin-2-amine, GLYCEROL, Heat shock protein HSP 90-alpha, ... | | 著者 | Fukami, T.A, Ono, N. | | 登録日 | 2011-07-21 | | 公開日 | 2011-09-14 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design
Bioorg.Med.Chem.Lett., 21, 2011
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5XS0
 | | Structure of a ssDNA bound to the outer DNA binding site of RAD52 | | 分子名称: | DNA repair protein RAD52 homolog, ssDNA (5'-D(*CP*CP*CP*CP*CP*C)-3'), ssDNA (5'-D(*CP*CP*CP*CP*CP*CP*CP*C)-3'), ... | | 著者 | Saotome, M, Saito, K, Yasuda, T, Sugiyama, S, Kurumizaka, H, Kagawa, W. | | 登録日 | 2017-06-11 | | 公開日 | 2018-04-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural Basis of Homology-Directed DNA Repair Mediated by RAD52
iScience, 3, 2018
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7VX3
 | | OXA-58 crystal structure of acylated meropenem complex 2 | | 分子名称: | (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, ... | | 著者 | Saino, H, Sugiyabu, T, Miyano, M. | | 登録日 | 2021-11-12 | | 公開日 | 2022-11-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | OXA-58 crystal structure of acylated meropenem complex 2
To be published
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7VX6
 | | OXA-58 crystal structure of acylated meropenem complex 2 | | 分子名称: | (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, ... | | 著者 | Saino, H, Sugiyabu, T, Miyano, M. | | 登録日 | 2021-11-12 | | 公開日 | 2022-11-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | OXA-58 crystal structure of acylated meropenem complex 2
To be published
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5XQY
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5XP1
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3AJB
 | | Crystal Structure of human Pex3p in complex with N-terminal Pex19p peptide | | 分子名称: | Peroxisomal biogenesis factor 19, Peroxisomal biogenesis factor 3 | | 著者 | Sato, Y, Shibata, H, Nakatsu, T, Kato, H. | | 登録日 | 2010-05-27 | | 公開日 | 2010-12-22 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p
Embo J., 29, 2010
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6AGT
 | | Crystal structure of PfKRS complexed with chromone inhibitor | | 分子名称: | COBALT (II) ION, FORMIC ACID, LYSINE, ... | | 著者 | Yogavel, M, Sharma, A, Sharma, A, Baragana, B, Walpole, C. | | 登録日 | 2018-08-14 | | 公開日 | 2019-03-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.953 Å) | | 主引用文献 | Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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3B26
 | | Hsp90 alpha N-terminal domain in complex with an inhibitor Ro1127850 | | 分子名称: | 4-(1H,3H-benzo[de]isochromen-6-yl)-6-methylpyrimidin-2-amine, Heat shock protein HSP 90-alpha | | 著者 | Fukami, T.A, Ono, N. | | 登録日 | 2011-07-21 | | 公開日 | 2011-09-14 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design
Bioorg.Med.Chem.Lett., 21, 2011
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2E3A
 | | Crystal structure of the NO-bound form of Arthromyces ramosus peroxidase at 1.3 Angstroms resolution | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, NITRIC OXIDE, ... | | 著者 | Fukuyama, K, Okada, T. | | 登録日 | 2006-11-22 | | 公開日 | 2007-03-20 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Structures of cyanide, nitric oxide and hydroxylamine complexes of Arthromyces ramosusperoxidase at 100 K refined to 1.3 A resolution: coordination geometries of the ligands to the haem iron
ACTA CRYSTALLOGR.,SECT.D, 63, 2007
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2E39
 | | Crystal structure of the CN-bound form of Arthromyces ramosus peroxidase at 1.3 Angstroms resolution | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CYANIDE ION, ... | | 著者 | Fukuyama, K, Okada, T. | | 登録日 | 2006-11-22 | | 公開日 | 2007-03-20 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Structures of cyanide, nitric oxide and hydroxylamine complexes of Arthromyces ramosusperoxidase at 100 K refined to 1.3 A resolution: coordination geometries of the ligands to the haem iron
ACTA CRYSTALLOGR.,SECT.D, 63, 2007
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2E3B
 | | Crystal structure of the HA-bound form of Arthromyces ramosus peroxidase at 1.3 Angstroms resolution | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, HYDROXYAMINE, ... | | 著者 | Fukuyama, K, Okada, T. | | 登録日 | 2006-11-22 | | 公開日 | 2007-03-20 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Structures of cyanide, nitric oxide and hydroxylamine complexes of Arthromyces ramosusperoxidase at 100 K refined to 1.3 A resolution: coordination geometries of the ligands to the haem iron
ACTA CRYSTALLOGR.,SECT.D, 63, 2007
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2D5R
 | | Crystal Structure of a Tob-hCaf1 Complex | | 分子名称: | CCR4-NOT transcription complex subunit 7, Tob1 protein | | 著者 | Horiuchi, M, Suzuki, N.N, Muroya, N, Takahasi, K, Nishida, M, Yoshida, Y, Ikematsu, N, Nakamura, T, Kawamura-Tsuzuku, J, Yamamoto, T, Inagaki, F. | | 登録日 | 2005-11-04 | | 公開日 | 2006-12-12 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural basis for the antiproliferative activity of the Tob-hCaf1 complex.
J.Biol.Chem., 284, 2009
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1X02
 | | Solution structure of stereo array isotope labeled (SAIL) calmodulin | | 分子名称: | CALCIUM ION, calmodulin | | 著者 | Kainosho, M, Torizawa, T, Terauchi, T, Ono, A.M, Guntert, P. | | 登録日 | 2005-03-11 | | 公開日 | 2006-03-07 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Optimal isotope labelling for NMR protein structure determinations.
Nature, 440, 2006
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2ZXX
 | | Crystal structure of Cdt1/geminin complex | | 分子名称: | DNA replication factor Cdt1, Geminin | | 著者 | Cho, Y, Lee, C, Hong, B.S, Choi, J.M. | | 登録日 | 2009-01-08 | | 公開日 | 2009-02-17 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural basis for inhibition of the replication licensing factor Cdt1 by geminin
Nature, 430, 2004
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3A4D
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3A4F
 | | Crystal Structure of Human Transthyretin (E54K) | | 分子名称: | GLYCEROL, SULFATE ION, Transthyretin | | 著者 | Miyata, M, Sato, T, Nakamura, T, Ikemizu, S, Yamagata, Y, Kai, H. | | 登録日 | 2009-07-06 | | 公開日 | 2009-12-22 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Role of the glutamic acid 54 residue in transthyretin stability and thyroxine binding
Biochemistry, 49, 2010
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1XFR
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2FLH
 | | Crystal structure of cytokinin-specific binding protein from mung bean in complex with cytokinin | | 分子名称: | (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol, SODIUM ION, cytokinin-specific binding protein | | 著者 | Pasternak, O, Bujacz, G.D, Sikorski, M.M, Jaskolski, M. | | 登録日 | 2006-01-06 | | 公開日 | 2006-11-21 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Crystal Structure of Vigna radiata Cytokinin-Specific Binding Protein in Complex with Zeatin.
Plant Cell, 18, 2006
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