2WAH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2wah by Molmil](/molmil-images/mine/2wah) | Crystal Structure of an IgG1 Fc Glycoform (Man9GlcNAc2) | 分子名称: | IG GAMMA-1 CHAIN C REGION, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Crispin, M, Bowden, T.A, Coles, C.H, Harlos, K, Aricescu, A.R, Harvey, D.J, Stuart, D.I, Jones, E.Y. | 登録日 | 2009-02-06 | 公開日 | 2009-03-10 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Carbohydrate and Domain Architecture of an Immature Antibody Glycoform Exhibiting Enhanced Effector Functions J.Mol.Biol., 387, 2009
|
|
2WG4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2wg4 by Molmil](/molmil-images/mine/2wg4) | Crystal structure of the complex between human hedgehog-interacting protein HIP and sonic hedgehog without calcium | 分子名称: | HEDGEHOG-INTERACTING PROTEIN, SODIUM ION, SONIC HEDGEHOG PROTEIN N-PRODUCT, ... | 著者 | Bishop, B, Aricescu, A.R, Harlos, K, O'Callaghan, C.A, Jones, E.Y, Siebold, C. | 登録日 | 2009-04-15 | 公開日 | 2009-06-30 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip Nat.Struct.Mol.Biol., 16, 2009
|
|
2WFX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2wfx by Molmil](/molmil-images/mine/2wfx) | Crystal structure of the complex between human hedgehog-interacting protein HIP and Sonic Hedgehog in the presence of calcium | 分子名称: | CALCIUM ION, HEDGEHOG-INTERACTING PROTEIN, SODIUM ION, ... | 著者 | Bishop, B, Aricescu, A.R, Harlos, K, O'Callaghan, C.A, Jones, E.Y, Siebold, C. | 登録日 | 2009-04-15 | 公開日 | 2009-06-30 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip Nat.Struct.Mol.Biol., 16, 2009
|
|
2WFQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2wfq by Molmil](/molmil-images/mine/2wfq) | Crystal structure of the N-terminal signalling domain of human Dhh without calcium | 分子名称: | DESERT HEDGEHOG PROTEIN N-PRODUCT, SULFATE ION, ZINC ION | 著者 | Bishop, B, Aricescu, A.R, Harlos, K, O'Callaghan, C.A, Jones, E.Y, Siebold, C. | 登録日 | 2009-04-14 | 公開日 | 2009-06-30 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip Nat.Struct.Mol.Biol., 16, 2009
|
|
2V5N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2v5n by Molmil](/molmil-images/mine/2v5n) | STRUCTURE OF HUMAN IGF2R DOMAINS 11-12 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR | 著者 | Brown, J, Delaine, C, Zaccheo, O.J, Siebold, C, Gilbert, R.J, van Boxel, G, Denley, A, Wallace, J.C, Hassan, A.B, Forbes, B.E, Jones, E.Y. | 登録日 | 2007-07-06 | 公開日 | 2007-12-11 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structure and Functional Analysis of the Igf-II/Igf2R Interaction Embo J., 27, 2008
|
|
2V5Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2v5y by Molmil](/molmil-images/mine/2v5y) | Crystal structure of the receptor protein tyrosine phosphatase mu ectodomain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE MU, SODIUM ION | 著者 | Aricescu, A.R, Siebold, C, Choudhuri, K, Chang, V.T, Lu, W, Davis, S.J, van der Merwe, P.A, Jones, E.Y. | 登録日 | 2007-07-11 | 公開日 | 2007-09-11 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structure of a Tyrosine Phosphatase Adhesive Interaction Reveals a Spacer-Clamp Mechanism. Science, 317, 2007
|
|
2WO2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2wo2 by Molmil](/molmil-images/mine/2wo2) | Crystal Structure of the EphA4-ephrinB2 complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, EPHRIN TYPE-A RECEPTOR, EPHRIN-B2 | 著者 | Bowden, T.A, Aricescu, A.R, Nettleship, J.E, Siebold, C, Rahman-Huq, N, Owens, R.J, Stuart, D.I, Jones, E.Y. | 登録日 | 2009-07-21 | 公開日 | 2009-10-27 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Structural Plasticity of Eph-Receptor A4 Facilitates Cross-Class Ephrin Signalling Structure, 17, 2009
|
|
2X10
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2x10 by Molmil](/molmil-images/mine/2x10) | Crystal structure of the complete EphA2 ectodomain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, EPHRIN TYPE-A RECEPTOR 2 | 著者 | Seiradake, E, Harlos, K, Sutton, G, Aricescu, A.R, Jones, E.Y. | 登録日 | 2009-12-21 | 公開日 | 2010-03-16 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | An Extracellular Steric Seeding Mechanism for Eph-Ephrin Signalling Platform Assembly Nat.Struct.Mol.Biol., 17, 2010
|
|
2V5O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2v5o by Molmil](/molmil-images/mine/2v5o) | STRUCTURE OF HUMAN IGF2R DOMAINS 11-14 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR, CHLORIDE ION | 著者 | Brown, J, Delaine, C, Zaccheo, O.J, Siebold, C, Gilbert, R.J, van Boxel, G, Denley, A, Wallace, J.C, Hassan, A.B, Forbes, B.E, Jones, E.Y. | 登録日 | 2007-07-06 | 公開日 | 2007-12-11 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | 主引用文献 | Structure and Functional Analysis of the Igf-II/Igf2R Interaction Embo J., 27, 2008
|
|
2WO3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2wo3 by Molmil](/molmil-images/mine/2wo3) | Crystal Structure of the EphA4-ephrinA2 complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, EPHRIN TYPE-A RECEPTOR, EPHRIN-A2 | 著者 | Bowden, T.A, Aricescu, A.R, Nettleship, J.E, Siebold, C, Rahman-Huq, N, Owens, R.J, Stuart, D.I, Jones, E.Y. | 登録日 | 2009-07-21 | 公開日 | 2009-10-27 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural Plasticity of Eph-Receptor A4 Facilitates Cross-Class Ephrin Signalling Structure, 17, 2009
|
|
2WJW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2wjw by Molmil](/molmil-images/mine/2wjw) | Crystal structure of the human ionotropic glutamate receptor GluR2 ATD region at 1.8 A resolution | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CHLORIDE ION, ... | 著者 | Clayton, A, Siebold, C, Gilbert, R.J.C, Sutton, G.C, Harlos, K, McIlhinney, R.A.J, Jones, E.Y, Aricescu, A.R. | 登録日 | 2009-06-01 | 公開日 | 2009-08-18 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal Structure of the Glur2 Amino-Terminal Domain Provides Insights Into the Architecture and Assembly of Ionotropic Glutamate Receptors. J.Mol.Biol., 392, 2009
|
|
2WG3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2wg3 by Molmil](/molmil-images/mine/2wg3) | Crystal structure of the complex between human hedgehog-interacting protein HIP and desert hedgehog without calcium | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, DESERT HEDGEHOG PROTEIN N-PRODUCT, ... | 著者 | Bishop, B, Aricescu, A.R, Harlos, K, O'Callaghan, C.A, Jones, E.Y, Siebold, C. | 登録日 | 2009-04-15 | 公開日 | 2009-06-30 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip Nat.Struct.Mol.Biol., 16, 2009
|
|
2WFT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2wft by Molmil](/molmil-images/mine/2wft) | Crystal structure of the human HIP ectodomain | 分子名称: | CHLORIDE ION, HEDGEHOG-INTERACTING PROTEIN, SODIUM ION | 著者 | Bishop, B, Aricescu, A.R, Harlos, K, O'Callaghan, C.A, Jones, E.Y, Siebold, C. | 登録日 | 2009-04-15 | 公開日 | 2009-06-30 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip Nat.Struct.Mol.Biol., 16, 2009
|
|
2WFO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2wfo by Molmil](/molmil-images/mine/2wfo) | Crystal structure of Machupo virus envelope glycoprotein GP1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCOPROTEIN 1 | 著者 | Bowden, T.A, Crispin, M, Graham, S.C, Harvey, D.J, Grimes, J.M, Jones, E.Y, Stuart, D.I. | 登録日 | 2009-04-09 | 公開日 | 2009-06-16 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Unusual Molecular Architecture of the Machupo Virus Attachment Glycoprotein. J.Virol., 83, 2009
|
|
2X9M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2x9m by Molmil](/molmil-images/mine/2x9m) | Hendra virus attachment glycoprotein | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCOPROTEIN G | 著者 | Bowden, T.A, Crispin, M, Harvey, D, Jones, E.Y, Stuart, D.I. | 登録日 | 2010-03-23 | 公開日 | 2010-04-21 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Dimeric Architecture of the Hendra Virus Attachment Glycoprotein: Evidence for a Conserved Mode of Assembly. J.Virol., 84, 2010
|
|
2VSK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2vsk by Molmil](/molmil-images/mine/2vsk) | Hendra virus attachment glycoprotein in complex with human cell surface receptor ephrinB2 | 分子名称: | EPHRIN-B2, HEMAGGLUTININ-NEURAMINIDASE | 著者 | Bowden, T.A, Aricescu, A.R, Gilbert, R.J, Grimes, J.M, Jones, E.Y, Stuart, D.I. | 登録日 | 2008-04-24 | 公開日 | 2008-05-20 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structural Basis of Nipah and Hendra Virus Attachment to Their Cell-Surface Receptor Ephrin-B2 Nat.Struct.Mol.Biol., 15, 2008
|
|
2WO1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2wo1 by Molmil](/molmil-images/mine/2wo1) | Crystal Structure of the EphA4 Ligand Binding Domain | 分子名称: | EPHRIN TYPE-A RECEPTOR, N-PROPANOL | 著者 | Bowden, T.A, Aricescu, A.R, Nettleship, J.E, Siebold, C, Rahman-Huq, N, Owens, R.J, Stuart, D.I, Jones, E.Y. | 登録日 | 2009-07-21 | 公開日 | 2009-10-27 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural Plasticity of Eph-Receptor A4 Facilitates Cross-Class Ephrin Signalling Structure, 17, 2009
|
|
2VGE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2vge by Molmil](/molmil-images/mine/2vge) | Crystal structure of the C-terminal region of human iASPP | 分子名称: | RELA-ASSOCIATED INHIBITOR | 著者 | Robinson, R.A, Lu, X, Jones, E.Y, Siebold, C. | 登録日 | 2007-11-12 | 公開日 | 2008-02-05 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Biochemical and Structural Studies of Aspp Proteins Reveal Differential Binding to P53, P63 and P73 Structure, 16, 2008
|
|
2WJX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2wjx by Molmil](/molmil-images/mine/2wjx) | Crystal structure of the human ionotropic glutamate receptor GluR2 ATD region at 4.1 A resolution | 分子名称: | GLUTAMATE RECEPTOR 2 | 著者 | Clayton, A, Siebold, C, Gilbert, R.J.C, Sutton, G.C, Harlos, K, McIlhinney, R.A.J, Jones, E.Y, Aricescu, A.R. | 登録日 | 2009-06-01 | 公開日 | 2009-08-18 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (4.1 Å) | 主引用文献 | Crystal Structure of the Glur2 Amino-Terminal Domain Provides Insights Into the Architecture and Assembly of Ionotropic Glutamate Receptors. J.Mol.Biol., 392, 2009
|
|
2X11
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2x11 by Molmil](/molmil-images/mine/2x11) | Crystal structure of the complete EphA2 ectodomain in complex with ephrin A5 receptor binding domain | 分子名称: | EPHRIN TYPE-A RECEPTOR 2, EPHRIN-A5 | 著者 | Seiradake, E, Harlos, K, Sutton, G, Aricescu, A.R, Jones, E.Y. | 登録日 | 2009-12-21 | 公開日 | 2010-03-16 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (4.83 Å) | 主引用文献 | An Extracellular Steric Seeding Mechanism for Eph-Ephrin Signalling Platform Assembly Nat.Struct.Mol.Biol., 17, 2010
|
|
6ZYF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6zyf by Molmil](/molmil-images/mine/6zyf) | Notum_Ghrelin complex | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Palmitoleoyl-protein carboxylesterase NOTUM, ... | 著者 | Zhao, Y, Jones, E.Y. | 登録日 | 2020-07-31 | 公開日 | 2021-03-10 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Notum deacylates octanoylated ghrelin. Mol Metab, 49, 2021
|
|
7B3P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7b3p by Molmil](/molmil-images/mine/7b3p) | Notum complex with ARUK3003775 | 分子名称: | 1,2-ETHANEDIOL, 6-((4-chlorophenyl)thio)-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one, DIMETHYL SULFOXIDE, ... | 著者 | Zhao, Y, Jones, E.Y, Fish, P. | 登録日 | 2020-12-01 | 公開日 | 2021-12-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | 主引用文献 | Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. J.Med.Chem., 65, 2022
|
|
7B3X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7b3x by Molmil](/molmil-images/mine/7b3x) | Notum complex with ARUK3003748 | 分子名称: | 6-(m-tolylthio)-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one, DIMETHYL SULFOXIDE, Palmitoleoyl-protein carboxylesterase NOTUM, ... | 著者 | Fish, P, Jones, E.Y. | 登録日 | 2020-12-01 | 公開日 | 2021-12-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | 主引用文献 | Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. J.Med.Chem., 65, 2022
|
|
7B45
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7b45 by Molmil](/molmil-images/mine/7b45) | Notum complex with ARUK3003934 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-(3-methylsulfanylphenyl)sulfanyl-2~{H}-[1,2,4]triazolo[4,3-b]pyridazin-3-one, ... | 著者 | Fish, P, Jones, E.Y. | 登録日 | 2020-12-02 | 公開日 | 2022-01-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. J.Med.Chem., 65, 2022
|
|
6ZUV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6zuv by Molmil](/molmil-images/mine/6zuv) | Notum fragment 286 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Palmitoleoyl-protein carboxylesterase NOTUM, ... | 著者 | Zhao, Y, Jones, E.Y. | 登録日 | 2020-07-23 | 公開日 | 2020-11-11 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | 5-Phenyl-1,3,4-oxadiazol-2(3 H )-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit. J.Med.Chem., 63, 2020
|
|