2C1E
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![BU of 2c1e by Molmil](/molmil-images/mine/2c1e) | Crystal structures of caspase-3 in complex with aza-peptide Michael acceptor inhibitors. | 分子名称: | AZA-PEPTIDE INHIBITOR (5S, 8R, 11S)-8-(2-CARBOXYETHYL)-5-(CARBOXYMETHYL)-14-(4-ETHOXY-4-OXOBUTANOYL)-11-(1-METHYLETHYL)-3,6,9,12-TETRAOXO-1-PHENYL-2-OXA-4,7,10,13,14-PENTAAZAHEXADECAN -16-OIC ACID, ... | 著者 | Grutter, M.G. | 登録日 | 2005-09-14 | 公開日 | 2006-09-20 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Selective and Potent Inhibitors of Caspases-2, -3, -6, -7, -8, -9, and - 10. J.Med.Chem., 49, 2006
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6U6U
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![BU of 6u6u by Molmil](/molmil-images/mine/6u6u) | IL36R extracellular domain in complex with BI655130 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BI00655130 Fab heavy chain, ... | 著者 | Larson, E.T, Farrow, N.A. | 登録日 | 2019-08-30 | 公開日 | 2020-04-22 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | X-ray crystal structure localizes the mechanism of inhibition of an IL-36R antagonist monoclonal antibody to interaction with Ig1 and Ig2 extra cellular domains. Protein Sci., 29, 2020
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2CCM
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![BU of 2ccm by Molmil](/molmil-images/mine/2ccm) | X-ray structure of Calexcitin from Loligo pealeii at 1.8A | 分子名称: | CALCIUM ION, CALEXCITIN | 著者 | Erskine, P.T, Beaven, G.D.E, Wood, S.P, Fox, G, Vernon, J, Giese, K.P, Cooper, J.B. | 登録日 | 2006-01-16 | 公開日 | 2006-01-26 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure of the Neuronal Protein Calexcitin Suggests a Mode of Interaction in Signalling Pathways of Learning and Memory. J.Mol.Biol., 357, 2006
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5WDO
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![BU of 5wdo by Molmil](/molmil-images/mine/5wdo) | H-Ras bound to GMP-PNP at 277K | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | 著者 | Cofsky, J.C, Bandaru, P, Gee, C.L, Kuriyan, J. | 登録日 | 2017-07-05 | 公開日 | 2017-07-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Deconstruction of the Ras switching cycle through saturation mutagenesis. Elife, 6, 2017
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5WDQ
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![BU of 5wdq by Molmil](/molmil-images/mine/5wdq) | H-Ras mutant L120A bound to GMP-PNP at 100K | 分子名称: | ACETATE ION, CALCIUM ION, GTPase HRas, ... | 著者 | Bandaru, P, Gee, C.L, Kuriyan, J. | 登録日 | 2017-07-05 | 公開日 | 2017-07-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Deconstruction of the Ras switching cycle through saturation mutagenesis. Elife, 6, 2017
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3EER
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![BU of 3eer by Molmil](/molmil-images/mine/3eer) | High resolution structure of putative organic hydroperoxide resistance protein from Vibrio cholerae O1 biovar eltor str. N16961 | 分子名称: | ACETATE ION, IMIDAZOLE, Organic hydroperoxide resistance protein, ... | 著者 | Nocek, B, Maltseva, N, Kwon, K, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2008-09-05 | 公開日 | 2008-10-21 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | High resolution crystal structure of the organic hydroperoxide
resistance protein from Vibrio cholerae O1 biovar eltor str. N16961 To be Published
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5WDS
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![BU of 5wds by Molmil](/molmil-images/mine/5wds) | Choanoflagellate Salpingoeca rosetta Ras with GDP bound | 分子名称: | GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Kondo, Y, Gee, C.L, Kuriyan, J. | 登録日 | 2017-07-05 | 公開日 | 2017-07-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Deconstruction of the Ras switching cycle through saturation mutagenesis. Elife, 6, 2017
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5WDP
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![BU of 5wdp by Molmil](/molmil-images/mine/5wdp) | H-Ras mutant L120A bound to GMP-PNP at 277K | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | 著者 | Cofsky, J.C, Bandaru, P, Gee, C.L, Kuriyan, J. | 登録日 | 2017-07-05 | 公開日 | 2017-07-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Deconstruction of the Ras switching cycle through saturation mutagenesis. Elife, 6, 2017
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5WDR
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![BU of 5wdr by Molmil](/molmil-images/mine/5wdr) | Choanoflagellate Salpingoeca rosetta Ras with GMP-PNP | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras protein, ... | 著者 | Kondo, Y, Gee, C.L, Kuriyan, J. | 登録日 | 2017-07-05 | 公開日 | 2017-07-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Deconstruction of the Ras switching cycle through saturation mutagenesis. Elife, 6, 2017
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4ZIL
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![BU of 4zil by Molmil](/molmil-images/mine/4zil) | Crystal structure of Rv2466c and oxidoreductase from Mycobacterium tuberculosis in its reduced state | 分子名称: | DSBA oxidoreductase, MAGNESIUM ION | 著者 | Albesa-Jove, D, Urresti, S, Comino, N, Tersa, M, Guerin, M.E. | 登録日 | 2015-04-28 | 公開日 | 2015-11-18 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.507 Å) | 主引用文献 | The Redox State Regulates the Conformation of Rv2466c to Activate the Antitubercular Prodrug TP053. J.Biol.Chem., 290, 2015
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4ZDJ
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![BU of 4zdj by Molmil](/molmil-images/mine/4zdj) | Crystal structure of the M. tuberculosis CTP synthase PyrG in complex with two UTP molecules | 分子名称: | CTP synthase, GLYCEROL, MAGNESIUM ION, ... | 著者 | Bellinzoni, M, Barilone, N, Alzari, P.M. | 登録日 | 2015-04-17 | 公開日 | 2015-07-01 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG. Chem.Biol., 22, 2015
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4ZDI
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4ZDK
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![BU of 4zdk by Molmil](/molmil-images/mine/4zdk) | Crystal structure of the M. tuberculosis CTP synthase PyrG in complex with UTP, AMP-PCP and oxonorleucine | 分子名称: | 5-OXO-L-NORLEUCINE, CTP synthase, MAGNESIUM ION, ... | 著者 | Bellinzoni, M, Barilone, N, Alzari, P.M. | 登録日 | 2015-04-17 | 公開日 | 2015-07-01 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.49 Å) | 主引用文献 | Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG. Chem.Biol., 22, 2015
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1HVX
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![BU of 1hvx by Molmil](/molmil-images/mine/1hvx) | BACILLUS STEAROTHERMOPHILUS ALPHA-AMYLASE | 分子名称: | ALPHA-AMYLASE, CALCIUM ION, SODIUM ION | 著者 | Suvd, D, Fujimoto, Z, Takase, K, Matsumura, M, Mizuno, H. | 登録日 | 2001-01-08 | 公開日 | 2001-01-31 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of Bacillus stearothermophilus alpha-amylase: possible factors determining the thermostability. J.Biochem., 129, 2001
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2MT7
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![BU of 2mt7 by Molmil](/molmil-images/mine/2mt7) | |
2OKW
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![BU of 2okw by Molmil](/molmil-images/mine/2okw) | |
3USB
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![BU of 3usb by Molmil](/molmil-images/mine/3usb) | Crystal Structure of Bacillus anthracis Inosine Monophosphate Dehydrogenase in the complex with IMP | 分子名称: | CHLORIDE ION, GLYCEROL, INOSINIC ACID, ... | 著者 | Kim, Y, Zhang, R, Wu, R, Gu, M, Anderson, W.F, Joachimiak, A, CSGID, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2011-11-23 | 公開日 | 2011-12-07 | 最終更新日 | 2019-08-14 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Bacillus anthracis inosine 5'-monophosphate dehydrogenase in action: the first bacterial series of structures of phosphate ion-, substrate-, and product-bound complexes. Biochemistry, 51, 2012
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5K10
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![BU of 5k10 by Molmil](/molmil-images/mine/5k10) | Cryo-EM structure of isocitrate dehydrogenase (IDH1) | 分子名称: | Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Merk, A, Bartesaghi, A, Banerjee, S, Falconieri, V, Rao, P, Earl, L, Milne, J, Subramaniam, S. | 登録日 | 2016-05-17 | 公開日 | 2016-06-08 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery. Cell, 165, 2016
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5K11
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![BU of 5k11 by Molmil](/molmil-images/mine/5k11) | Cryo-EM structure of isocitrate dehydrogenase (IDH1) in inhibitor-bound state | 分子名称: | Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Merk, A, Bartesaghi, A, Banerjee, S, Falconieri, V, Rao, P, Earl, L, Milne, J, Subramaniam, S. | 登録日 | 2016-05-17 | 公開日 | 2016-06-08 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery. Cell, 165, 2016
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5K12
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![BU of 5k12 by Molmil](/molmil-images/mine/5k12) | Cryo-EM structure of glutamate dehydrogenase at 1.8 A resolution | 分子名称: | Glutamate dehydrogenase 1, mitochondrial | 著者 | Merk, A, Bartesaghi, A, Banerjee, S, Falconieri, V, Rao, P, Earl, L, Milne, J, Subramaniam, S. | 登録日 | 2016-05-17 | 公開日 | 2016-06-08 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (1.8 Å) | 主引用文献 | Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery. Cell, 165, 2016
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6JYG
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![BU of 6jyg by Molmil](/molmil-images/mine/6jyg) | Crystal Structure of L-threonine dehydrogenase from Phytophthora infestans | 分子名称: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, CITRATE ANION, L-threonine 3-dehydrogenase, ... | 著者 | Yoneda, K, Sakuraba, H, Ohshima, T. | 登録日 | 2019-04-26 | 公開日 | 2020-04-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Catalytic properties and crystal structure of UDP-galactose 4-epimerase-like l-threonine 3-dehydrogenase from Phytophthora infestans. Enzyme.Microb.Technol., 140, 2020
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7UAD
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![BU of 7uad by Molmil](/molmil-images/mine/7uad) | Crystal structure of human PTPN2 with inhibitor ABBV-CLS-484 | 分子名称: | 5-{(7R)-1-fluoro-3-hydroxy-7-[(3-methylbutyl)amino]-5,6,7,8-tetrahydronaphthalen-2-yl}-1lambda~6~,2,5-thiadiazolidine-1,1,3-trione, Tyrosine-protein phosphatase non-receptor type 2 | 著者 | Longenecker, K.L, Qiu, W, Sun, Q, Frost, J.M. | 登録日 | 2022-03-12 | 公開日 | 2023-07-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.044 Å) | 主引用文献 | The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity. Nature, 622, 2023
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6ARO
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6AOX
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6AS8
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