6LW0
| Crystal structure of TLR7/Cpd-6 (DSR-139293) complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-ethoxy-8-(5-fluoranylpyridin-3-yl)-9-[[4-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]methyl]purin-6-amine, ... | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | 登録日 | 2020-02-06 | 公開日 | 2020-11-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural analysis reveals TLR7 dynamics underlying antagonism. Nat Commun, 11, 2020
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6LW1
| Cryo-EM structure of TLR7/Cpd-7 (DSR-139970) complex in open form | 分子名称: | 2-ethoxy-8-(5-fluoranylpyridin-3-yl)-6-methyl-9-[[4-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]methyl]purine, Toll-like receptor 7 | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | 登録日 | 2020-02-06 | 公開日 | 2020-11-11 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural analysis reveals TLR7 dynamics underlying antagonism. Nat Commun, 11, 2020
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6LVZ
| Crystal structure of TLR7/Cpd-3 (SM-394830) complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-(2-methoxyethoxy)-9-(pyridin-3-ylmethyl)-7H-purin-8-one, ... | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | 登録日 | 2020-02-06 | 公開日 | 2020-11-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | Structural analysis reveals TLR7 dynamics underlying antagonism. Nat Commun, 11, 2020
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6LVX
| Crystal structure of TLR7/Cpd-1 (SM-374527) complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-butoxy-9-(phenylmethyl)-7H-purin-8-one, ... | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | 登録日 | 2020-02-06 | 公開日 | 2020-11-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | Structural analysis reveals TLR7 dynamics underlying antagonism. Nat Commun, 11, 2020
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8ZMR
| Vesamicol-bound VAChT | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,Vesicular acetylcholine transporter,DARPinoff7, vesamicol | 著者 | Zhang, Z, Zhang, Y, Dai, F, Zhang, Y.X, Lee, C.-H. | 登録日 | 2024-05-23 | 公開日 | 2024-06-19 | 最終更新日 | 2024-09-18 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural insights into VAChT neurotransmitter recognition and inhibition. Cell Res., 34, 2024
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8ZMS
| Acetylcholine-bound VAChT | 分子名称: | ACETYLCHOLINE, Maltose/maltodextrin-binding periplasmic protein,Vesicular acetylcholine transporter,DARPinoff7 | 著者 | Zhang, Z, Zhang, Y, Dai, F, Zhang, Y.X, Lee, C.-H. | 登録日 | 2024-05-23 | 公開日 | 2024-06-19 | 最終更新日 | 2024-09-18 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural insights into VAChT neurotransmitter recognition and inhibition. Cell Res., 34, 2024
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8GS3
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7KKH
| P1A4 Fab in complex with ARS1620 | 分子名称: | (S)-1-{4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl] piperazin-1-yl}propan-1-one, P1A4 Fab Heavy Chain, P1A4 Fab Light Chain, ... | 著者 | Basu, K, Rohweder, P.J, Zhang, Z, Bohn, M.-F, Shokat, K, Craik, C.S. | 登録日 | 2020-10-27 | 公開日 | 2022-04-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy. Cancer Cell, 40, 2022
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7E7X
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8HGS
| The EGF-bound EGFR ectodomain homodimer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, Pro-epidermal growth factor, ... | 著者 | Zhang, Z, Bai, X. | 登録日 | 2022-11-15 | 公開日 | 2023-02-15 | 最終更新日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (3.81 Å) | 主引用文献 | Structure and dynamics of the EGFR/HER2 heterodimer. Cell Discov, 9, 2023
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8HGO
| The EGF-bound EGFR/HER2 ectodomain complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor, ... | 著者 | Zhang, Z, Bai, X. | 登録日 | 2022-11-15 | 公開日 | 2023-02-08 | 最終更新日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | 主引用文献 | Structure and dynamics of the EGFR/HER2 heterodimer. Cell Discov, 9, 2023
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8HGP
| The EREG-bound EGFR/HER2 ectodomain complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, ... | 著者 | Zhang, Z, Bai, X. | 登録日 | 2022-11-15 | 公開日 | 2023-02-08 | 最終更新日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (4.53 Å) | 主引用文献 | Structure and dynamics of the EGFR/HER2 heterodimer. Cell Discov, 9, 2023
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8Y3X
| Cell divisome sPG hydrolysis machinery FtsEX-EnvC | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell division ATP-binding protein FtsE, Cell division protein FtsX, ... | 著者 | Zhang, Z, Dong, H, Chen, Y. | 登録日 | 2024-01-29 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Structure and activity of the septal peptidoglycan hydrolysis machinery crucial for bacterial cell division. Plos Biol., 22, 2024
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8HIJ
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8HIK
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8HII
| The BRIL-SLC19A1/Fab/Nb ternary complex | 分子名称: | BRIL-SLC19A1 chimera, anti-BRIL Fab heavy chain, anti-BRIL Fab light chain, ... | 著者 | Zhang, Z, Dang, Y. | 登録日 | 2022-11-20 | 公開日 | 2022-12-21 | 最終更新日 | 2023-01-11 | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | 主引用文献 | Molecular mechanism of substrate recognition by folate transporter SLC19A1. Cell Discov, 8, 2022
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7XR4
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7XR6
| Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with WAY-213613 | 分子名称: | (2S)-2-azanyl-4-[[4-[2-bromanyl-4,5-bis(fluoranyl)phenoxy]phenyl]amino]-4-oxidanylidene-butanoic acid, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Zhao, Y, Zhang, Z. | 登録日 | 2022-05-09 | 公開日 | 2022-06-22 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis of ligand binding modes of human EAAT2. Nat Commun, 13, 2022
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8WX5
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8WX4
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8WX3
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8WX2
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7Y0W
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7Y0C
| Crystal structure of BD55-1403 and SARS-CoV-2 Omicron RBD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, BD55-1403 Fab heavy chain, BD55-1403 Fab light chain, ... | 著者 | Zhang, Z, Xiao, J. | 登録日 | 2022-06-04 | 公開日 | 2022-09-28 | 最終更新日 | 2023-04-12 | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | 主引用文献 | Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents. Cell Rep, 41, 2022
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8JHB
| FZD6 Gs complex | 分子名称: | Frizzled-6, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, F, Zhang, Z. | 登録日 | 2023-05-23 | 公開日 | 2024-01-17 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways. Cell Discov, 10, 2024
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