3H6K
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![BU of 3h6k by Molmil](/molmil-images/mine/3h6k) | |
7WRY
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![BU of 7wry by Molmil](/molmil-images/mine/7wry) | |
3HFG
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7E7E
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![BU of 7e7e by Molmil](/molmil-images/mine/7e7e) | The co-crystal structure of ACE2 with Fab | 分子名称: | Processed angiotensin-converting enzyme 2, ZINC ION, h11B11-Fab | 著者 | Xiao, J.Y, Zhang, Y. | 登録日 | 2021-02-26 | 公開日 | 2021-07-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants. Nat Commun, 12, 2021
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3DPC
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8HF8
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![BU of 8hf8 by Molmil](/molmil-images/mine/8hf8) | Human PPAR delta ligand binding domain in complex with a synthetic agonist V1 | 分子名称: | 2-[4-[[2,5-bis(oxidanylidene)-3-[4-(trifluoromethyl)phenyl]imidazolidin-1-yl]methyl]-2,6-dimethyl-phenoxy]-2-methyl-propanoic acid, Peroxisome proliferator-activated receptor delta, octyl beta-D-glucopyranoside | 著者 | Dai, L, Sun, H.B, Yuan, H.L, Feng, Z.Q. | 登録日 | 2022-11-09 | 公開日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Discovery of the First Subnanomolar PPAR alpha / delta Dual Agonist for the Treatment of Cholestatic Liver Diseases. J.Med.Chem., 66, 2023
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4JZR
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![BU of 4jzr by Molmil](/molmil-images/mine/4jzr) | Structure of Prolyl Hydroxylase Domain-containing Protein (PHD) with Inhibitors | 分子名称: | 1,2-ETHANEDIOL, 2-(biphenyl-4-yl)-8-[(1-methyl-1H-imidazol-2-yl)methyl]-2,8-diazaspiro[4.5]decan-1-one, Egl nine homolog 1, ... | 著者 | Ma, Y, Yang, L. | 登録日 | 2013-04-03 | 公開日 | 2013-10-30 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Novel complex crystal structure of prolyl hydroxylase domain-containing protein 2 (PHD2): 2,8-Diazaspiro[4.5]decan-1-ones as potent, orally bioavailable PHD2 inhibitors Bioorg.Med.Chem., 21, 2013
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3PS6
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7WB5
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![BU of 7wb5 by Molmil](/molmil-images/mine/7wb5) | local structure of hu33 and spike | 分子名称: | Surface glycoprotein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, hu33 heavy chain, ... | 著者 | Pulan, L. | 登録日 | 2021-12-15 | 公開日 | 2022-10-26 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | A non-ACE2-blocking neutralizing antibody against Omicron-included SARS-CoV-2 variants. Signal Transduct Target Ther, 7, 2022
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7WBH
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![BU of 7wbh by Molmil](/molmil-images/mine/7wbh) | overall structure of hu33 and spike | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Pulan, L. | 登録日 | 2021-12-16 | 公開日 | 2022-10-26 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | A non-ACE2-blocking neutralizing antibody against Omicron-included SARS-CoV-2 variants. Signal Transduct Target Ther, 7, 2022
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3PRE
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![BU of 3pre by Molmil](/molmil-images/mine/3pre) | Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors. | 分子名称: | 2-amino-8-(trans-4-methoxycyclohexyl)-4-methyl-6-(1H-pyrazol-3-yl)pyrido[2,3-d]pyrimidin-7(8H)-one, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 著者 | Knighton, D.R, Greasley, S.E, Rodgers, C.M.-L. | 登録日 | 2010-11-29 | 公開日 | 2011-02-09 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | 主引用文献 | Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors. Bioorg.Med.Chem.Lett., 21, 2011
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3PRZ
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7EY5
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7EZV
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7EY4
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6FKQ
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![BU of 6fkq by Molmil](/molmil-images/mine/6fkq) | THE CRYSTAL STRUCTURE OF A FRAGMENT OF NETRIN-1 IN COMPLEX WITH A FRAGMENT OF DRAXIN | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Bhowmick, T, Meijers, R. | 登録日 | 2018-01-24 | 公開日 | 2018-03-21 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.07 Å) | 主引用文献 | Structural Basis for Draxin-Modulated Axon Guidance and Fasciculation by Netrin-1 through DCC. Neuron, 97, 2018
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7W0G
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![BU of 7w0g by Molmil](/molmil-images/mine/7w0g) | Human PPAR delta ligand binding domain in complex with a synthetic agonist H11 | 分子名称: | 2-[2,6-dimethyl-4-[[5-oxidanylidene-4-[4-(trifluoromethyloxy)phenyl]-1,2,4-triazol-1-yl]methyl]phenoxy]-2-methyl-propanoic acid, Peroxisome proliferator-activated receptor delta | 著者 | Dai, L, Sun, H.B, Yuan, H.L, Feng, Z.Q. | 登録日 | 2021-11-18 | 公開日 | 2022-02-02 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.443 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of Triazolone Derivatives as Potent PPAR alpha / delta Dual Agonists for the Treatment of Nonalcoholic Steatohepatitis. J.Med.Chem., 65, 2022
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7W0S
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![BU of 7w0s by Molmil](/molmil-images/mine/7w0s) | TRIM7 in complex with C-terminal peptide of 2C | 分子名称: | DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase TRIM7, GLYCEROL, ... | 著者 | Zhang, H, Liang, X, Li, X.Z. | 登録日 | 2021-11-18 | 公開日 | 2022-08-10 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures. Nat.Chem.Biol., 18, 2022
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7W0T
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7W0Q
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7X6Z
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7X70
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7X6Y
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5YL9
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![BU of 5yl9 by Molmil](/molmil-images/mine/5yl9) | |