3H6K

Crystal Structure of Human 11-beta-hydroxysteroid-dehydrogenase Bound to an Ortho-chlro-sulfonyl-piperazine Inhibitor

Summary for 3H6K

DescriptorCorticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-chloro-4-({(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl}sulfonyl)benzamide, ... (4 entities in total)
Functional Keywordsoxidoreductase, hsd1, nadp, inhibitor, endoplasmic reticulum, glycoprotein, lipid metabolism, membrane, polymorphism, signal-anchor, steroid metabolism, transmembrane
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane ; Single-pass type II membrane protein  P28845
Total number of polymer chains4
Total molecular weight132240.62
Authors
Bard, J.,Svenson, K. (deposition date: 2009-04-23, release date: 2009-12-01, Last modification date: 2017-11-01)
Primary citation
Wan, Z.K.,Chenail, E.,Xiang, J.,Li, H.Q.,Ipek, M.,Bard, J.,Svenson, K.,Mansour, T.S.,Xu, X.,Tian, X.,Suri, V.,Hahm, S.,Xing, Y.,Johnson, C.E.,Li, X.,Qadri, A.,Panza, D.,Perreault, M.,Tobin, J.F.,Saiah, E.
Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model.
J.Med.Chem., 52:5449-5461, 2009
PubMed: 19673466 (PDB entries with the same primary citation)
DOI: 10.1021/jm900639u
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.187 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers131.2%4.9%4.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution