5Y0F
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6MTJ
| Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-378806 in Complex with Human Antibodies 3H109L and 35O22 at 2.9 Angstrom | 分子名称: | 1-[(2R)-4-(benzenecarbonyl)-2-methylpiperazin-1-yl]-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Lai, Y.-T, Kwong, P.D. | 登録日 | 2018-10-19 | 公開日 | 2019-01-16 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.336 Å) | 主引用文献 | Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry. Nat Commun, 10, 2019
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5Y12
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6MUF
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6MTN
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6MU8
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6MU6
| Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-814508 in Complex with Human Antibodies 3H109L and 35O22 at 3.2 Angstrom | 分子名称: | (2R)-{1-[{7-[2-({[3-(dimethylamino)propyl](methyl)amino}methyl)-1,3-thiazol-4-yl]-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl}(oxo)acetyl]piperidin-4-yl}(phenyl)acetonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Lai, Y.-T, Kwong, P.D. | 登録日 | 2018-10-22 | 公開日 | 2019-01-16 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.551 Å) | 主引用文献 | Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry. Nat Commun, 10, 2019
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6ORT
| Crystal Structure of Bos taurus Mxra8 Ectodomain | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, Matrix remodeling-associated protein 8 | 著者 | Fremont, D.H, Kim, A.S, Nelson, C.A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2019-04-30 | 公開日 | 2020-03-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis. Cell Host Microbe, 27, 2020
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5DJ4
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4YD0
| Influenza polymerase basic protein 2 (PB2) bound to an azaindole-tetrazole inhibitor | 分子名称: | 2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoro-N-[(1R,2S,3S,4R)-3-(1H-tetrazol-5-yl)bicyclo[2.2.2]oct-2-yl]pyrimidin-4-amine, Polymerase basic protein 2 | 著者 | Jacobs, M.D. | 登録日 | 2015-02-20 | 公開日 | 2015-04-15 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
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5B7J
| Structure model of Sap1-DNA complex | 分子名称: | DNA (5'-D(*AP*AP*TP*AP*TP*TP*GP*TP*TP*TP*TP*G)-3'), DNA (5'-D(*CP*AP*AP*AP*AP*CP*AP*AP*TP*AP*TP*T)-3'), Switch-activating protein 1 | 著者 | Jin, C, Hu, Y, Ding, J, Zhang, Y. | 登録日 | 2016-06-07 | 公開日 | 2017-02-22 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Sap1 is a replication-initiation factor essential for the assembly of pre-replicative complex in the fission yeast Schizosaccharomyces pombe J. Biol. Chem., 292, 2017
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3MKA
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7DD2
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7DK4
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3MGM
| Crystal structure of human NUDT16 | 分子名称: | U8 snoRNA-decapping enzyme | 著者 | Yan, J, Lu, G, Zhang, J, Qi, J, Li, Z, Gao, F. | 登録日 | 2010-04-07 | 公開日 | 2011-04-20 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Crystal structure and the template mRNA decapping activity of human NUDT16 To be Published
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3MI0
| Crystal Structure of Mycobacterium Tuberculosis Proteasome at 2.2 A | 分子名称: | (2R,3S,4R)-2-[(S)-(1S)-cyclohex-2-en-1-yl(hydroxy)methyl]-4-ethyl-3-hydroxy-3-methyl-5-oxopyrrolidine-2-carbaldehyde, DIMETHYLFORMAMIDE, Proteasome subunit alpha, ... | 著者 | Li, D, Li, H. | 登録日 | 2010-04-09 | 公開日 | 2010-06-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis for the assembly and gate closure mechanisms of the Mycobacterium tuberculosis 20S proteasome. Embo J., 2010
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7DDN
| SARS-Cov2 S protein at open state | 分子名称: | Spike glycoprotein | 著者 | Cong, Y, Liu, C.X. | 登録日 | 2020-10-29 | 公開日 | 2020-11-25 | 最終更新日 | 2021-01-27 | 実験手法 | ELECTRON MICROSCOPY (6.3 Å) | 主引用文献 | Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections. Nat Commun, 12, 2021
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7DDD
| SARS-Cov2 S protein at close state | 分子名称: | Spike glycoprotein | 著者 | Cong, Y, Liu, C.X. | 登録日 | 2020-10-28 | 公開日 | 2020-11-25 | 最終更新日 | 2021-01-27 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections. Nat Commun, 12, 2021
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7DK7
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7DCX
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7DK6
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7DCC
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7DD8
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7DK5
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3MFE
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