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Growth Factor Crystal Structure at 1.97 Angstrom Resolution
分子名称:	Growth/differentiation factor 15
著者	Lakshminarasimhan, D, White, A, Suto, R.K.
登録日	2017-05-26
公開日	2017-09-27
最終更新日	2017-10-25
実験手法	X-RAY DIFFRACTION (1.97 Å)
主引用文献	Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15. Nature, 550, 2017

5WBI

Crystal structure of the Arabidopsis thaliana Raptor
分子名称:	Regulatory-associated protein of TOR 1
著者	Pavletich, N.P, Jiang, X.
登録日	2017-06-29
公開日	2017-12-20
最終更新日	2024-03-13
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017

5CET

Crystal structure of Rv2837c
分子名称:	Bifunctional oligoribonuclease and PAP phosphatase NrnA, MANGANESE (II) ION
著者	Wang, F, He, Q, Zhu, D, Liu, S, Gu, L.
登録日	2015-07-07
公開日	2015-12-23
最終更新日	2024-03-20
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Structural and Biochemical Insight into the Mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP Phosphodiesterase J.Biol.Chem., 291, 2016

5WBU

Crystal structure of mTOR(deltaN)-mLST8-PRAS40(alpha-helix & beta-strand) complex
分子名称:	Proline-rich AKT1 substrate 1, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8
著者	Pavletich, N.P, Yang, H.
登録日	2017-06-29
公開日	2017-12-20
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (3.42 Å)
主引用文献	Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017

5WBJ

Crystal structure of the arabidopsis thaliana Raptor in complex with the TOS peptide of human 4EBP1
分子名称:	Eukaryotic translation initiation factor 4E-binding protein 1, Regulatory-associated protein of TOR 1
著者	Pavletich, N.P, Jiang, X.
登録日	2017-06-29
公開日	2017-12-20
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017

5WBY

Crystal structure of mTOR(deltaN)-mLST8-PRAS40(beta-strand) complex
分子名称:	Proline-rich AKT1 substrate 1, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8
著者	Pavletich, N.P, Yang, H.
登録日	2017-06-29
公開日	2017-12-20
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (3.1 Å)
主引用文献	Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017

5X0S

Solution NMR structure of peptide toxin SsTx from Scolopendra subspinipes mutilans
分子名称:	SsTx
著者	Wu, F, Luo, L, Qu, D, Zhang, L, Tian, C, Lai, R.
登録日	2017-01-23
公開日	2018-01-24
最終更新日	2023-06-14
実験手法	SOLUTION NMR
主引用文献	Centipedes subdue giant prey by blocking KCNQ channels Proc. Natl. Acad. Sci. U.S.A., 115, 2018

4R8Q

Structure and substrate recruitment of the human spindle checkpoint kinase bub1
分子名称:	ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mitotic checkpoint serine/threonine-protein kinase BUB1
著者	Tomchick, D.R, Yu, H.
登録日	2014-09-02
公開日	2014-11-12
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.31 Å)
主引用文献	Structure and substrate recruitment of the human spindle checkpoint kinase Bub1. Mol.Cell, 32, 2008

2VPF

VASCULAR ENDOTHELIAL GROWTH FACTOR REFINED TO 1.93 ANGSTROMS RESOLUTION
分子名称:	VASCULAR ENDOTHELIAL GROWTH FACTOR
著者	Muller, Y.A, De Vos, A.M.
登録日	1997-07-29
公開日	1998-07-29
最終更新日	2023-08-09
実験手法	X-RAY DIFFRACTION (1.93 Å)
主引用文献	The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 A resolution: multiple copy flexibility and receptor binding. Structure, 5, 1997

7DC3

Crystal structure of the MyRF ICA domain
分子名称:	Isoform 2 of Myelin regulatory factor
著者	Shi, N, Wu, P, Zhen, X.K, Li, B.W.
登録日	2020-10-23
公開日	2021-08-25
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Crystal structure of the MyRF ICA domain with its upstream beta-helical stalk reveals the molecular mechanisms underlying its trimerization and self-cleavage. Int J Biol Sci, 17, 2021

7VD4

Crystal structure of BPTF-BRD with ligand TP248 bound
分子名称:	6-[4-[3-(dimethylamino)propoxy]phenyl]-N-methyl-2-methylsulfonyl-pyrimidin-4-amine, Nucleosome-remodeling factor subunit BPTF
著者	Lu, T, Lu, H.B.
登録日	2021-09-06
公開日	2022-09-14
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.85659146 Å)
主引用文献	Discovery of a highly potent CECR2 bromodomain inhibitor with 7H-pyrrolo[2,3-d] pyrimidine scaffold. Bioorg.Chem., 123, 2022

6JTD

Crystal structure of TcCGT1 in complex with UDP
分子名称:	1,2-ETHANEDIOL, C-glycosyltransferase, URIDINE-5'-DIPHOSPHATE
著者	Zhao, P, Yun, C.H.
登録日	2019-04-10
公開日	2019-06-19
最終更新日	2024-03-27
実験手法	X-RAY DIFFRACTION (1.85 Å)
主引用文献	Molecular and Structural Characterization of a Promiscuous C-Glycosyltransferase from Trollius chinensis. Angew.Chem.Int.Ed.Engl., 58, 2019

6JPD

Mouse receptor-interacting protein kinase 3 (RIP3) amyloid structure by solid-state NMR
分子名称:	Receptor-interacting serine/threonine-protein kinase 3
著者	Wu, X.L, Hu, H, Zhang, J, Dong, X.Q, Wang, J, Schwieters, C, Wang, H.Y, Lu, J.X.
登録日	2019-03-26
公開日	2020-10-28
最終更新日	2024-05-15
実験手法	SOLID-STATE NMR
主引用文献	The amyloid structure of mouse RIPK3 (receptor interacting protein kinase 3) in cell necroptosis. Nat Commun, 12, 2021

6I3N

Helical MyD88 death domain filament
分子名称:	Myeloid differentiation primary response protein MyD88
著者	Moncrieffe, M.C, Bollschweiler, D, Penczek, P.A.P, Gay, N.J.
登録日	2018-11-06
公開日	2019-11-20
最終更新日	2024-05-15
実験手法	ELECTRON MICROSCOPY (3.1 Å)
主引用文献	MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling. Structure, 28, 2020

6KI0

Crystal Structure of Human ASC-CARD
分子名称:	Maltose/maltodextrin-binding periplasmic protein,Apoptosis-associated speck-like protein containing a CARD, SULFATE ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者	Xu, Z.H, Jin, T.C.
登録日	2019-07-16
公開日	2020-07-22
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Homotypic CARD-CARD interaction is critical for the activation of NLRP1 inflammasome. Cell Death Dis, 12, 2021

6VHJ

Solution NMR of Prochlorosin 1.1 produced by Prochlorococcus MIT 9313
分子名称:	Prochlorosin 1.1
著者	Bobeica, S.C, van der Donk, W.A, Tang, W.
登録日	2020-01-09
公開日	2020-07-08
最終更新日	2023-06-14
実験手法	SOLUTION NMR
主引用文献	Structural determinants of macrocyclization in substrate-controlled lanthipeptide biosynthetic pathways. Chem Sci, 11, 2020

6VJQ

Solution NMR structure of Prochlorosin 2.1 produced by Prochlorococcus MIT 9313
分子名称:	Prochlorosin 2.1
著者	Bobeica, S.C, van der Donk, W.A, Zhu, L.
登録日	2020-01-16
公開日	2020-07-08
最終更新日	2023-06-14
実験手法	SOLUTION NMR
主引用文献	Structural determinants of macrocyclization in substrate-controlled lanthipeptide biosynthetic pathways. Chem Sci, 11, 2020

6VLJ

Solution NMR of Prochlorosin 2.8 produced by Prochlorococcus MIT 9313
分子名称:	Prochlorosin 2.8
著者	Bobeica, S.C, Acedo, J.Z, van der Donk, W.A, Zhu, L.
登録日	2020-01-24
公開日	2020-07-08
最終更新日	2023-06-14
実験手法	SOLUTION NMR
主引用文献	Structural determinants of macrocyclization in substrate-controlled lanthipeptide biosynthetic pathways. Chem Sci, 11, 2020

7CYF

Cryo-EM structure of bicarbonate transporter SbtA in complex with PII-like signaling protein SbtB from Synechocystis sp. PCC 6803
分子名称:	ADENOSINE MONOPHOSPHATE, Membrane-associated protein slr1513, SODIUM ION, ...
著者	Liu, X.Y, Jiang, Y.L, Wang, L, Hou, W.T, Chen, Y, Zhou, C.Z.
登録日	2020-09-03
公開日	2021-06-23
最終更新日	2022-02-16
実験手法	ELECTRON MICROSCOPY (3.15 Å)
主引用文献	Structures of cyanobacterial bicarbonate transporter SbtA and its complex with PII-like SbtB. Cell Discov, 7, 2021

7CYE

Cryo-EM structure of sodium-dependent bicarbonate transporter SbtA from Synechocystis sp. PCC 6803
分子名称:	Slr1512 protein
著者	Liu, X.Y, Jiang, Y.L, Wang, L, Hou, W.T, Chen, Y, Zhou, C.Z.
登録日	2020-09-03
公開日	2021-06-23
最終更新日	2024-05-29
実験手法	ELECTRON MICROSCOPY (3.54 Å)
主引用文献	Structures of cyanobacterial bicarbonate transporter SbtA and its complex with PII-like SbtB. Cell Discov, 7, 2021

7D4B

Crystal structure of 4-1BB in complex with a VHH
分子名称:	1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
著者	Wang, C.
登録日	2020-09-23
公開日	2021-07-14
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (3.14 Å)
主引用文献	Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer. J Immunother Cancer, 9, 2021

7CZD

Crystal structure of PD-L1 in complex with a VHH
分子名称:	1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Programmed cell death 1 ligand 1, ...
著者	Wang, C.
登録日	2020-09-08
公開日	2021-07-14
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.64 Å)
主引用文献	Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer. J Immunother Cancer, 9, 2021

1ZV1

Crystal structure of the dimerization domain of doublesex protein from D. melanogaster
分子名称:	Doublesex protein
著者	Weiss, M.A, Bayrer, J.R, Wan, Z, Li, B, Phillips, N.B.
登録日	2005-06-01
公開日	2005-08-09
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Dimerization of doublesex is mediated by a cryptic ubiquitin-associated domain fold: implications for sex-specific gene regulation J.Biol.Chem., 280, 2005

7D7F

Structure of PKD1L3-CTD/PKD2L1 in calcium-bound state
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Polycystic kidney disease 2-like 1 protein, ...
著者	Su, Q, Shi, Y.G.
登録日	2020-10-03
公開日	2021-09-01
実験手法	ELECTRON MICROSCOPY (3 Å)
主引用文献	Structural basis for Ca 2+ activation of the heteromeric PKD1L3/PKD2L1 channel. Nat Commun, 12, 2021

1YCS

P53-53BP2 COMPLEX
分子名称:	53BP2, P53, ZINC ION
著者	Gorina, S, Pavletich, N.P.
登録日	1996-09-30
公開日	1997-11-19
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2. Science, 274, 1996

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