3MO2
 
 | | human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E67 | | 分子名称: | 7-[(5-aminopentyl)oxy]-N~4~-(1-benzylpiperidin-4-yl)-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, ... | | 著者 | Chang, Y, Horton, J.R, Cheng, X. | | 登録日 | 2010-04-22 | | 公開日 | 2010-06-30 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases.
J.Mol.Biol., 400, 2010
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3MO5
 | | Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E72 | | 分子名称: | 7-[(5-aminopentyl)oxy]-N~4~-[1-(5-aminopentyl)piperidin-4-yl]-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, ... | | 著者 | Chang, Y, Horton, J.R, Cheng, X. | | 登録日 | 2010-04-22 | | 公開日 | 2010-06-30 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | | 主引用文献 | Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases.
J.Mol.Biol., 400, 2010
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1BQK
 | | OXIDIZED PSEUDOAZURIN | | 分子名称: | COPPER (II) ION, PSEUDOAZURIN | | 著者 | Inoue, T, Nishio, N, Hamanaka, S, Shimomura, T, Harada, S, Suzuki, S, Kohzuma, T, Shidara, S, Iwasaki, H, Kai, Y. | | 登録日 | 1998-08-17 | | 公開日 | 1999-08-17 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Crystal structure determinations of oxidized and reduced pseudoazurins from Achromobacter cycloclastes. Concerted movement of copper site in redox forms with the rearrangement of hydrogen bond at a remote histidine.
J.Biol.Chem., 274, 1999
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1N27
 | | Solution structure of the PWWP domain of mouse Hepatoma-derived growth factor, related protein 3 | | 分子名称: | Hepatoma-derived growth factor, related protein 3 | | 著者 | Nameki, N, Kigawa, T, Koshiba, S, Kobayashi, N, Tochio, N, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2002-10-22 | | 公開日 | 2003-12-23 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the PWWP domain of the hepatoma-derived growth factor family.
Protein Sci., 14, 2005
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2ROZ
 | | Structure of the C-terminal PID Domain of Fe65L1 Complexed with the Cytoplasmic Tail of APP Reveals a Novel Peptide Binding Mode | | 分子名称: | Amyloid beta A4 precursor protein-binding family B member 2, peptide from Amyloid beta A4 protein | | 著者 | Li, H, Koshiba, S, Tochio, N, Watanabe, S, Harada, T, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2008-04-25 | | 公開日 | 2008-07-22 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the C-terminal phosphotyrosine interaction domain of Fe65L1 complexed with the cytoplasmic tail of amyloid precursor protein reveals a novel peptide binding mode
J.Biol.Chem., 283, 2008
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6PGO
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6PGP
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7SR8
 | | Molecular mechanism of the the wake-promoting agent TAK-925 | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Hypocretin receptor type 2, ... | | 著者 | Yin, J, Chapman, K, Lian, P, De Brabander, J.K, Rosenbaum, D.M. | | 登録日 | 2021-11-08 | | 公開日 | 2022-06-08 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Molecular mechanism of the wake-promoting agent TAK-925.
Nat Commun, 13, 2022
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6OR6
 | | Full-length S. pombe Mdn1 in the presence of AMPPNP (tail region) | | 分子名称: | Midasin | | 著者 | Chen, Z, Suzuki, H, Wang, A.C, DiMaio, F, Walz, T, Kapoor, T.M. | | 登録日 | 2019-04-29 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (5.3 Å) | | 主引用文献 | Structural Insights into Mdn1, an Essential AAA Protein Required for Ribosome Biogenesis.
Cell, 175, 2018
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6OR5
 | | Full-length S. pombe Mdn1 in the presence of AMPPNP (ring region) | | 分子名称: | Midasin, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | 著者 | Chen, Z, Suzuki, H, Wang, A.C, DiMaio, F, Walz, T, Kapoor, T.M. | | 登録日 | 2019-04-29 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structural Insights into Mdn1, an Essential AAA Protein Required for Ribosome Biogenesis.
Cell, 175, 2018
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4EBV
 | | Structure of Focal Adhesion Kinase catalytic domain in complex with novel allosteric inhibitor | | 分子名称: | 8-(4-ethylphenyl)-5-methyl-2,5-dihydropyrazolo[4,3-c][2,1]benzothiazine 4,4-dioxide, Focal adhesion kinase 1, ISOPROPYL ALCOHOL | | 著者 | Skene, R.J, Hosfield, D.J. | | 登録日 | 2012-03-25 | | 公開日 | 2012-08-22 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | Discovery and characterization of novel allosteric FAK inhibitors.
Eur.J.Med.Chem., 61, 2013
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6ORB
 | | Full-length S. pombe Mdn1 in the presence of ATP and Rbin-1 | | 分子名称: | Midasin | | 著者 | Chen, Z, Suzuki, H, Wang, A.C, DiMaio, F, Walz, T, Kapoor, T.M. | | 登録日 | 2019-04-29 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (7.7 Å) | | 主引用文献 | Structural Insights into Mdn1, an Essential AAA Protein Required for Ribosome Biogenesis.
Cell, 175, 2018
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8E22
 | | VPS37A_21-148 | | 分子名称: | Vacuolar protein sorting-associated protein 37A | | 著者 | Tian, F, Ye, Y.S. | | 登録日 | 2022-08-12 | | 公開日 | 2023-08-09 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Identification of membrane curvature sensing motifs essential for VPS37A phagophore recruitment and autophagosome closure.
Commun Biol, 7, 2024
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3I8U
 | | Crystal structure of PcyA-181,182-dihydrobiliverdin complex | | 分子名称: | 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-2-ylidene]methy l]-5-[(Z)-(4-ethyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid, Phycocyanobilin:ferredoxin oxidoreductase | | 著者 | Hagiwara, Y, Sugishima, M, Fukuyama, K. | | 登録日 | 2009-07-10 | | 公開日 | 2009-10-27 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Structural insights into vinyl reduction regiospecificity of phycocyanobilin:ferredoxin oxidoreductase (PcyA).
To be Published
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3I95
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6UIN
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4XY2
 | | Crystal structure of PDE10A in complex with ASP9436 | | 分子名称: | 1-methyl-5-(1-methyl-3-{[4-(1-methyl-1H-benzimidazol-4-yl)phenoxy]methyl}-1H-pyrazol-4-yl)pyridin-2(1H)-one, MAGNESIUM ION, ZINC ION, ... | | 著者 | Amano, Y, Honbou, K. | | 登録日 | 2015-02-02 | | 公開日 | 2015-06-17 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Addressing phototoxicity observed in a novel series of biaryl derivatives: Discovery of potent, selective and orally active phosphodiesterase 10A inhibitor ASP9436
Bioorg.Med.Chem., 23, 2015
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6UG1
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8GU3
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7BI1
 | | XFEL crystal structure of soybean ascorbate peroxidase compound II | | 分子名称: | Ascorbate peroxidase, POTASSIUM ION, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Kwon, H, Tosha, T, Sugimoto, H, Raven, E.L, Moody, P.C.E. | | 登録日 | 2021-01-12 | | 公開日 | 2021-04-21 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | XFEL Crystal Structures of Peroxidase Compound II.
Angew.Chem.Int.Ed.Engl., 60, 2021
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7BIU
 | | XFEL crystal structure of cytochrome c peroxidase compound II | | 分子名称: | Cytochrome c peroxidase, mitochondrial, HEME C | | 著者 | Kwon, H, Tosha, T, Sugimoto, H, Raven, E.L, Moody, P.C.E. | | 登録日 | 2021-01-13 | | 公開日 | 2021-04-21 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.06 Å) | | 主引用文献 | XFEL Crystal Structures of Peroxidase Compound II.
Angew.Chem.Int.Ed.Engl., 60, 2021
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5AWO
 | | Arthrobacter globiformis T6 isomalto-dextranse | | 分子名称: | ACETATE ION, Isomaltodextranase, PHOSPHATE ION | | 著者 | Tonozuka, T. | | 登録日 | 2015-07-08 | | 公開日 | 2015-09-09 | | 最終更新日 | 2020-02-26 | | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | | 主引用文献 | Crystal Structure and Mutational Analysis of Isomalto-dextranase, a Member of Glycoside Hydrolase Family 27
J.Biol.Chem., 290, 2015
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4YSH
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5AWP
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5AWQ
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