5HMY
| Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 15 | 分子名称: | 2,2'-(5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-1,3-phenylene)diacetic acid, RNA-directed RNA polymerase NS5, ZINC ION | 著者 | Noble, C.G. | 登録日 | 2016-01-17 | 公開日 | 2016-03-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design. J.Med.Chem., 59, 2016
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5HMW
| Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 5 | 分子名称: | 2,2'-biphenyl-3,5-diyldiacetic acid, RNA-directed RNA polymerase NS5, ZINC ION | 著者 | Noble, C.G. | 登録日 | 2016-01-17 | 公開日 | 2016-03-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design J.Med.Chem., 59, 2016
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5HN0
| Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 4 | 分子名称: | (6-hydroxybiphenyl-3-yl)acetic acid, RNA-directed RNA polymerase NS5, ZINC ION | 著者 | Noble, C.G. | 登録日 | 2016-01-17 | 公開日 | 2016-03-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design. J.Med.Chem., 59, 2016
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3NCX
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3NCW
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6POH
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6PML
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6PMF
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6POI
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6POQ
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5ZLK
| Mutation in the trinuclear site of CotA-laccase: H493A mutant, PH 8.0 | 分子名称: | 1,2-ETHANEDIOL, COPPER (II) ION, GLYCEROL, ... | 著者 | Xie, T, Liu, Z.C, Wang, G.G. | 登録日 | 2018-03-28 | 公開日 | 2018-05-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural Insight into the Allosteric Coupling of Cu1 Site and Trinuclear Cu Cluster in CotA Laccase. Chembiochem, 19, 2018
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5ZLM
| Mutation in the trinuclear site of CotA-laccase: H491C mutant, PH 8.0 | 分子名称: | 1,2-ETHANEDIOL, COPPER (II) ION, GLYCEROL, ... | 著者 | Xie, T, Liu, Z.C, Wang, G.G. | 登録日 | 2018-03-28 | 公開日 | 2018-05-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural Insight into the Allosteric Coupling of Cu1 Site and Trinuclear Cu Cluster in CotA Laccase. Chembiochem, 19, 2018
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8HGH
| Structure of 2:2 PAPP-A.STC2 complex | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,Pappalysin-1, Stanniocalcin-2, ZINC ION | 著者 | Zhong, Q.H, Chu, H.L, Wang, G.P, Zhang, C, Wei, Y, Qiao, J, Hang, J. | 登録日 | 2022-11-14 | 公開日 | 2023-01-11 | 実験手法 | ELECTRON MICROSCOPY (4.16 Å) | 主引用文献 | Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2. Cell Discov, 8, 2022
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8HGG
| Structure of 2:2 PAPP-A.ProMBP complex | 分子名称: | Bone marrow proteoglycan, Pappalysin-1, ZINC ION | 著者 | Zhong, Q.H, Chu, H.L, Wang, G.P, Zhang, C, Wei, Y, Qiao, J, Hang, J. | 登録日 | 2022-11-14 | 公開日 | 2023-01-11 | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | 主引用文献 | Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2. Cell Discov, 8, 2022
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5ZLL
| Mutation in the trinuclear site of CotA-laccase: H493C mutant, PH 8.0 | 分子名称: | 1,2-ETHANEDIOL, COPPER (II) ION, GLYCEROL, ... | 著者 | Xie, T, Liu, Z.C, Wang, G.G. | 登録日 | 2018-03-28 | 公開日 | 2018-05-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural Insight into the Allosteric Coupling of Cu1 Site and Trinuclear Cu Cluster in CotA Laccase. Chembiochem, 19, 2018
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5ZLJ
| Crystal structure of CotA native enzyme, PH8.0 | 分子名称: | 1,2-ETHANEDIOL, COPPER (II) ION, GLYCEROL, ... | 著者 | Xie, T, Liu, Z.C, Wang, G.G. | 登録日 | 2018-03-28 | 公開日 | 2018-05-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Structural Insight into the Allosteric Coupling of Cu1 Site and Trinuclear Cu Cluster in CotA Laccase. Chembiochem, 19, 2018
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7LHP
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5V8O
| Discovery of a high affinity inhibitor of cGAS | 分子名称: | 5-phenyltetrazolo[1,5-a]pyrimidin-7-ol, Cyclic GMP-AMP synthase, ZINC ION | 著者 | Hall, J. | 登録日 | 2017-03-22 | 公開日 | 2017-09-27 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS ONE, 12, 2017
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7MW3
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7MW4
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5HS2
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7MW6
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7MW5
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7MW2
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4OEW
| Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors | 分子名称: | 6-ethyl-5-iodo-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one, MAGNESIUM ION, ZINC ION, ... | 著者 | Chen, T.T, Ren, J, Xu, Y.C. | 登録日 | 2014-01-14 | 公開日 | 2015-04-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | Thermodynamic and structural characterization of halogen bonding in protein-ligand interactions: a case study of PDE5 and its inhibitors. J.Med.Chem., 57, 2014
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