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7W67
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BU of 7w67 by Molmil
The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me0 peptide
分子名称: Histone H3.3C, Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, ...
著者Zhao, L, Li, Y, Chen, Y.
登録日2021-12-01
公開日2022-09-07
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.194 Å)
主引用文献Structural basis for product specificities of MLL family methyltransferases.
Mol.Cell, 82, 2022
7W6J
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BU of 7w6j by Molmil
The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me2 peptide
分子名称: Histone H3.3C, Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, ...
著者Zhao, L, Li, Y, Chen, Y.
登録日2021-12-01
公開日2022-09-07
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Structural basis for product specificities of MLL family methyltransferases.
Mol.Cell, 82, 2022
7CHV
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BU of 7chv by Molmil
Metallo-Beta-Lactamase VIM-2 in complex with 1-benzyl-1H-imidazole-2-carboxylic acid
分子名称: 1-(phenylmethyl)imidazole-2-carboxylic acid, Beta-lactamase class B VIM-2, FORMIC ACID, ...
著者Yan, Y.-H, Li, G.-B.
登録日2020-07-06
公開日2021-07-14
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.174 Å)
主引用文献AncPhore: A versatile tool for anchor pharmacophore steered drug discovery with applications in discovery of new inhibitors targeting metallo-beta-lactamases and indoleamine/tryptophan 2,3-dioxygenases.
Acta Pharm Sin B, 11, 2021
7YSR
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BU of 7ysr by Molmil
GTPgammaS MT decorated with kinesin
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Tubulin alpha chain, ...
著者Zhou, J, Wang, H.-W.
登録日2022-08-12
公開日2023-10-18
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Structural insights into the mechanism of GTP initiation of microtubule assembly.
Nat Commun, 14, 2023
7YSP
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BU of 7ysp by Molmil
Tubulin heterodimer structure of GDP-2 state in solution
分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Tubulin alpha-1B chain, ...
著者Zhou, J, Wang, H.-W.
登録日2022-08-12
公開日2023-10-18
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structural insights into the mechanism of GTP initiation of microtubule assembly.
Nat Commun, 14, 2023
7YSN
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BU of 7ysn by Molmil
Tubulin heterodimer structure of GMPCPP state in solution
分子名称: GUANOSINE-5'-TRIPHOSPHATE, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, Tubulin alpha-1B chain, ...
著者Zhou, J, Wang, H.-W.
登録日2022-08-12
公開日2023-10-18
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural insights into the mechanism of GTP initiation of microtubule assembly.
Nat Commun, 14, 2023
7YSQ
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BU of 7ysq by Molmil
GTPgammaS Tube decorated with kinesin
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Tubulin alpha chain, ...
著者Zhou, J, Wang, H.-W.
登録日2022-08-12
公開日2023-10-18
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (6.8 Å)
主引用文献Structural insights into the mechanism of GTP initiation of microtubule assembly.
Nat Commun, 14, 2023
7YSO
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BU of 7yso by Molmil
Tubulin heterodimer structure of GDP-1 state in solution
分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Tubulin alpha-1B chain, ...
著者Zhou, J, Wang, H.-W.
登録日2022-08-12
公開日2023-10-18
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structural insights into the mechanism of GTP initiation of microtubule assembly.
Nat Commun, 14, 2023
7DML
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BU of 7dml by Molmil
OXA-48 carbapenemase in complex with (R)-2-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)acrylic acid
分子名称: 2-[(3R)-1-oxidanyl-3H-2,1-benzoxaborol-3-yl]prop-2-enoic acid, Beta-lactamase
著者Li, G.-B, Yan, Y.-H.
登録日2020-12-04
公開日2021-12-15
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.936 Å)
主引用文献Design and enantioselective synthesis of 3-(alpha-acrylic acid) benzoxaboroles to combat carbapenemase resistance
Chem.Commun.(Camb.), 57, 2021
7E9A
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BU of 7e9a by Molmil
Crystal structure of KPC-2 in complex with (S)-2-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)acrylic acid (4a-(S))
分子名称: 2-[(3S)-1-oxidanyl-3H-2,1-benzoxaborol-3-yl]prop-2-enoic acid, ACETIC ACID, Beta-lactamase, ...
著者Li, G.-B, Yan, Y.-H.
登録日2021-03-03
公開日2021-08-04
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Design and enantioselective synthesis of 3-( alpha-acrylic acid) benzoxaboroles to combat carbapenemase resistance.
Chem.Commun.(Camb.), 57, 2021
3CIB
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BU of 3cib by Molmil
Structure of BACE Bound to SCH727596
分子名称: Beta-secretase 1, D(-)-TARTARIC ACID, N'-[(1S,2R)-2-[(2R,4S)-4-benzylpiperidin-2-yl]-1-(3,5-difluorobenzyl)-2-hydroxyethyl]-5-methyl-N,N-dipropylbenzene-1,3-dicarboxamide
著者Strickland, C, Cumming, J.
登録日2008-03-11
公開日2008-06-10
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors
Bioorg.Med.Chem.Lett., 18, 2008
6XP9
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BU of 6xp9 by Molmil
STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN BOUND TETHERED WITH SRC co-activator peptide IN COMPLEX WITH (S,S)-1
分子名称: (2S)-tert-butoxy[7-(8-fluoro-5-methyl-3,4-dihydro-2H-1-benzopyran-6-yl)-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl]acetic acid, GLYCEROL, Nuclear receptor subfamily 1 group I member 2,Nuclear receptor coactivator 1 fusion
著者Khan, J.A.
登録日2020-07-08
公開日2020-09-23
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Structure-based amelioration of PXR transactivation in a novel series of macrocyclic allosteric inhibitors of HIV-1 integrase.
Bioorg.Med.Chem.Lett., 30, 2020
2QIC
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BU of 2qic by Molmil
Crystal Structure of the ING1 PHD Finger in complex with a Histone H3K4ME3 peptide
分子名称: H3K4ME3 PEPTIDE, Inhibitor of growth protein 1, ZINC ION
著者Pena, P.V, Champagne, K, Zhao, R, Kutateladze, T.G.
登録日2007-07-03
公開日2008-05-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor.
J.Mol.Biol., 380, 2008
7UP2
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BU of 7up2 by Molmil
NDM1-inhibitor co-structure
分子名称: (2M)-4'-methyl-2-(2H-tetrazol-5-yl)[1,1'-biphenyl]-3-sulfonamide, Beta-lactamase VIM-1, ZINC ION
著者Scapin, G, Fischmann, T.O.
登録日2022-04-14
公開日2023-03-08
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.13 Å)
主引用文献Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
J.Med.Chem., 65, 2022
7UP1
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BU of 7up1 by Molmil
NDM1-inhibitor co-structure
分子名称: (2M)-4'-methyl-2-(2H-tetrazol-5-yl)[1,1'-biphenyl]-3-sulfonamide, CADMIUM ION, Metallo beta-lactamase, ...
著者Scapin, G, Fischmann, T.O.
登録日2022-04-14
公開日2023-03-08
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.11 Å)
主引用文献Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
J.Med.Chem., 65, 2022
7UP3
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BU of 7up3 by Molmil
NDM1-inhibitor co-structure
分子名称: (3P)-4-[4-(hydroxymethyl)phenyl]-3-(2H-tetrazol-5-yl)pyridine-2-sulfonamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CADMIUM ION, ...
著者Scapin, G, Fischmann, T.O.
登録日2022-04-14
公開日2023-03-08
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
J.Med.Chem., 65, 2022
7UOX
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BU of 7uox by Molmil
NDM1-inhibitor co-structure
分子名称: (2M)-4'-(hydroxymethyl)-2-(1H-tetrazol-5-yl)[1,1'-biphenyl]-3-ol, ACETATE ION, CADMIUM ION, ...
著者Scapin, G, Fischmann, T.O.
登録日2022-04-14
公開日2023-03-08
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (0.99 Å)
主引用文献Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
J.Med.Chem., 65, 2022
7UOY
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BU of 7uoy by Molmil
NDM1-inhibitor co-structure
分子名称: (6P)-4-amino-6-(2H-tetrazol-5-yl)benzene-1,3-disulfonamide, CADMIUM ION, Metallo beta-lactamase, ...
著者Scapin, G, Fischmann, T.O.
登録日2022-04-14
公開日2023-03-08
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
J.Med.Chem., 65, 2022
7YRD
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BU of 7yrd by Molmil
histone methyltransferase
分子名称: DNA (146-MER), Histone H2A.Z, Histone H2B 1.1, ...
著者Li, H, Wang, W.Y.
登録日2022-08-09
公開日2023-08-16
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural insight into H4K20 methylation on H2A.Z-nucleosome by SUV420H1.
Mol.Cell, 83, 2023
7YRG
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BU of 7yrg by Molmil
histone methyltransferase
分子名称: DNA (146-MER), Histone H2A.Z, Histone H2B 1.1, ...
著者Li, H, Wang, W.Y.
登録日2022-08-09
公開日2023-12-13
最終更新日2025-06-18
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Structural insight into H4K20 methylation on H2A.Z-nucleosome by SUV420H1.
Mol.Cell, 83, 2023
7V99
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BU of 7v99 by Molmil
catalytic core of human telomerase holoenzyme
分子名称: Histone H2A type 1-B/E, Histone H2B type 1-K, Primer DNA, ...
著者Wan, F, Ding, Y, Yang, L, Wu, Z, Wu, J, Lei, M.
登録日2021-08-24
公開日2022-03-30
最終更新日2024-10-30
実験手法ELECTRON MICROSCOPY (3.54 Å)
主引用文献Zipper head mechanism of telomere synthesis by human telomerase.
Cell Res., 31, 2021
7V9A
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BU of 7v9a by Molmil
biogenesis module of human telomerase holoenzyme
分子名称: H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ...
著者Wan, F, Ding, Y, Yang, L, Wu, Z, Wu, J, Lei, M.
登録日2021-08-24
公開日2022-03-30
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.94 Å)
主引用文献Zipper head mechanism of telomere synthesis by human telomerase.
Cell Res., 31, 2021
7X08
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BU of 7x08 by Molmil
S protein of SARS-CoV-2 in complex with 2G1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LINOLEIC ACID, ...
著者Guo, Y.Y, Zhang, Y.Y, Zhou, Q.
登録日2022-02-21
公開日2022-03-09
最終更新日2024-11-06
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD.
Cell Discov, 8, 2022
6KE4
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BU of 6ke4 by Molmil
ABloop reengineered Ferritin Nanocage
分子名称: CALCIUM ION, CHLORIDE ION, FE (III) ION, ...
著者Wang, W.M, Wang, H.F.
登録日2019-07-03
公開日2019-10-23
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献AB loop engineered ferritin nanocages for drug loading under benign experimental conditions.
Chem.Commun.(Camb.), 55, 2019
7V2Y
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BU of 7v2y by Molmil
cryo-EM structure of yeast THO complex with Sub2
分子名称: ATP-dependent RNA helicase SUB2, Protein TEX1, THO complex subunit 2, ...
著者Chen, C, Tan, M, Wu, Z, Wu, J, Lei, M.
登録日2021-08-10
公開日2022-07-27
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex.
Sci Bull (Beijing), 66, 2021

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件を2025-07-09に公開中

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