7E9A

Crystal structure of KPC-2 in complex with (S)-2-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)acrylic acid (4a-(S))

Summary for 7E9A

Entry DOI	10.2210/pdb7e9a/pdb
Descriptor	Beta-lactamase, 2-[(3S)-1-oxidanyl-3H-2,1-benzoxaborol-3-yl]prop-2-enoic acid, ACETIC ACID, ... (6 entities in total)
Functional Keywords	beta-lactamase, serine-beta-lactamase kpc-2, kpc-2, carbapenemase, hydrolase
Biological source	Klebsiella pneumoniae
Total number of polymer chains	4
Total formula weight	114928.20
Authors	Li, G.-B.,Yan, Y.-H. (deposition date: 2021-03-03, release date: 2021-08-04, Last modification date: 2023-11-29)
Primary citation	Xiao, Y.C.,Chen, X.P.,Deng, J.,Yan, Y.H.,Zhu, K.R.,Li, G.,Yu, J.L.,Brem, J.,Chen, F.,Schofield, C.J.,Li, G.B. Design and enantioselective synthesis of 3-( alpha-acrylic acid) benzoxaboroles to combat carbapenemase resistance. Chem.Commun.(Camb.), 57:7709-7712, 2021 Cited by PubMed: 34259249 DOI: 10.1039/d1cc03026d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation