8WAR
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![BU of 8war by Molmil](/molmil-images/mine/8war) | Structure of transcribing complex 8 (TC8), the initially transcribing complex with Pol II positioned 8nt downstream of TSS. | 分子名称: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | 著者 | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | 登録日 | 2023-09-08 | 公開日 | 2023-12-06 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (7.2 Å) | 主引用文献 | Structural visualization of transcription initiation in action. Science, 382, 2023
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8WAU
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![BU of 8wau by Molmil](/molmil-images/mine/8wau) | De novo transcribing complex 11 (TC11), the early elongation complex with Pol II positioned 11nt downstream of TSS | 分子名称: | Alpha-amanitin, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | 著者 | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | 登録日 | 2023-09-08 | 公開日 | 2023-12-06 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (2.78 Å) | 主引用文献 | Structural visualization of transcription initiation in action. Science, 382, 2023
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3Q7J
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![BU of 3q7j by Molmil](/molmil-images/mine/3q7j) | Engineered Thermoplasma Acidophilum F3 factor mimics human aminopeptidase N (APN) as a target for anticancer drug development | 分子名称: | L-phenylalanyl-N6-[(benzyloxy)carbonyl]-N1-hydroxy-L-lysinamide, Tricorn protease-interacting factor F3, ZINC ION | 著者 | Su, J, Wang, Q, Feng, J, Zhang, C, Zhu, D, We, T, Xu, W, Gu, L. | 登録日 | 2011-01-05 | 公開日 | 2011-07-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | 主引用文献 | Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development Bioorg.Med.Chem., 19, 2011
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4IJS
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4JHD
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![BU of 4jhd by Molmil](/molmil-images/mine/4jhd) | Crystal Structure of an Actin Dimer in Complex with the Actin Nucleator Cordon-Bleu | 分子名称: | Actin-5C, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Chen, X, Ni, F, Wang, Q. | 登録日 | 2013-03-04 | 公開日 | 2013-06-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | 主引用文献 | Structural basis of actin filament nucleation by tandem w domains. Cell Rep, 3, 2013
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4J40
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![BU of 4j40 by Molmil](/molmil-images/mine/4j40) | Crystal structure of the dual-domain GGDEF-EAL module of FimX from Pseudomonas aeruginosa | 分子名称: | FimX | 著者 | Navarro, M.V, De, N, Bae, N, Wang, Q, Sondermann, H. | 登録日 | 2013-02-06 | 公開日 | 2013-02-20 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | Structural analysis of the GGDEF-EAL domain-containing c-di-GMP receptor FimX. Structure, 17, 2009
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7VZF
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![BU of 7vzf by Molmil](/molmil-images/mine/7vzf) | Cryo-EM structure of amyloid fibril formed by full-length human SOD1 | 分子名称: | Superoxide dismutase [Cu-Zn] | 著者 | Wang, L.Q, Ma, Y.Y, Yuan, H.Y, Zhao, K, Zhang, M.Y, Wang, Q, Huang, X, Xu, W.C, Chen, J, Li, D, Zhang, D.L, Zou, L.Y, Yin, P, Liu, C, Liang, Y. | 登録日 | 2021-11-16 | 公開日 | 2022-06-29 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its conformational conversion. Nat Commun, 13, 2022
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4KPH
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![BU of 4kph by Molmil](/molmil-images/mine/4kph) | Structure of the Fab fragment of N62, a protective monoclonal antibody to the nonreducing end of Francisella tularensis O-antigen | 分子名称: | ACETATE ION, N62 heavy chain, N62 light chain | 著者 | Lu, Z, Rynkiewicz, M.J, Yang, C.-Y, Madico, G, Perkins, H.M, Wang, Q, Costello, C.E, Zaia, J, Seaton, B.A, Sharon, J. | 登録日 | 2013-05-13 | 公開日 | 2013-07-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | The binding sites of monoclonal antibodies to the non-reducing end of Francisella tularensis O-antigen accommodate mainly the terminal saccharide. Immunology, 140, 2013
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4KR0
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![BU of 4kr0 by Molmil](/molmil-images/mine/4kr0) | Complex structure of MERS-CoV spike RBD bound to CD26 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4, ... | 著者 | Lu, G, Hu, Y, Wang, Q, Qi, J, Gao, F, Li, Y, Zhang, Y, Zhang, W, Yuan, Y, Zhang, B, Shi, Y, Yan, J, Gao, G.F. | 登録日 | 2013-05-15 | 公開日 | 2013-07-10 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.702 Å) | 主引用文献 | Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature, 500, 2013
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4KQZ
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![BU of 4kqz by Molmil](/molmil-images/mine/4kqz) | structure of the receptor binding domain (RBD) of MERS-CoV spike | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, S protein | 著者 | Lu, G, Hu, Y, Wang, Q, Qi, J, Gao, F, Li, Y, Zhang, Y, Zhang, W, Yuan, Y, Bao, J, Zhang, B, Shi, Y, Yan, J, Gao, G.F. | 登録日 | 2013-05-15 | 公開日 | 2013-07-10 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.514 Å) | 主引用文献 | Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature, 500, 2013
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4LLA
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![BU of 4lla by Molmil](/molmil-images/mine/4lla) | Crystal structure of D3D4 domain of the LILRB2 molecule | 分子名称: | Leukocyte immunoglobulin-like receptor subfamily B member 2 | 著者 | Nam, G, Shi, Y, Ryu, M, Wang, Q, Song, H, Liu, J, Yan, J, Qi, J, Gao, G.F. | 登録日 | 2013-07-09 | 公開日 | 2013-09-11 | 最終更新日 | 2013-11-06 | 実験手法 | X-RAY DIFFRACTION (2.502 Å) | 主引用文献 | Crystal structures of the two membrane-proximal Ig-like domains (D3D4) of LILRB1/B2: alternative models for their involvement in peptide-HLA binding Protein Cell, 4, 2013
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4LL9
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![BU of 4ll9 by Molmil](/molmil-images/mine/4ll9) | Crystal structure of D3D4 domain of the LILRB1 molecule | 分子名称: | IODIDE ION, Leukocyte immunoglobulin-like receptor subfamily B member 1 | 著者 | Nam, G, Shi, Y, Ryu, M, Wang, Q, Song, H, Liu, J, Yan, J, Qi, J, Gao, G.F. | 登録日 | 2013-07-09 | 公開日 | 2013-09-11 | 最終更新日 | 2013-11-06 | 実験手法 | X-RAY DIFFRACTION (2.686 Å) | 主引用文献 | Crystal structures of the two membrane-proximal Ig-like domains (D3D4) of LILRB1/B2: alternative models for their involvement in peptide-HLA binding Protein Cell, 4, 2013
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7T90
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![BU of 7t90 by Molmil](/molmil-images/mine/7t90) | Cryo-EM structure of ACh-bound M2R-Go signaling complex in S2 state | 分子名称: | ACETYLCHOLINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, J, Wang, Q, Du, Y, Kobilka, B.K. | 登録日 | 2021-12-17 | 公開日 | 2023-01-25 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor. Nat Commun, 14, 2023
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7T8X
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![BU of 7t8x by Molmil](/molmil-images/mine/7t8x) | Cryo-EM structure of ACh-bound M2R-Go signaling complex in S1 state | 分子名称: | ACETYLCHOLINE, Antibody fragment, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Xu, J, Wang, Q, Du, Y, Kobilka, B.K. | 登録日 | 2021-12-17 | 公開日 | 2023-01-25 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | 主引用文献 | Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor. Nat Commun, 14, 2023
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7T96
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![BU of 7t96 by Molmil](/molmil-images/mine/7t96) | Cryo-EM structure of S2 state ACh-bound M2R-Go signaling complex with a PAM | 分子名称: | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, ACETYLCHOLINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Xu, J, Wang, Q, Du, Y, Kobilka, B.K. | 登録日 | 2021-12-18 | 公開日 | 2023-01-25 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor. Nat Commun, 14, 2023
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7T94
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![BU of 7t94 by Molmil](/molmil-images/mine/7t94) | Cryo-EM structure of S1 state ACh-bound M2R-Go signaling complex with a PAM | 分子名称: | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, ACETYLCHOLINE, Antibody fragment, ... | 著者 | Xu, J, Wang, Q, Du, Y, Kobilka, B.K. | 登録日 | 2021-12-17 | 公開日 | 2023-01-25 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | 主引用文献 | Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor. Nat Commun, 14, 2023
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4DUI
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![BU of 4dui by Molmil](/molmil-images/mine/4dui) | DARPIN D1 binding to tubulin beta chain (not in complex) | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN) D1 | 著者 | Pecqueur, L, Duellberg, C, Dreier, B, Wang, Q, Jiang, C, Pluckthun, A, Surrey, T, Gigant, B, Knossow, M. | 登録日 | 2012-02-22 | 公開日 | 2013-02-27 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.16 Å) | 主引用文献 | An Anti-Tubulin Darpin Caps the Microtubule Plus-End To be Published
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4E42
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![BU of 4e42 by Molmil](/molmil-images/mine/4e42) | Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4 | 分子名称: | CHLORIDE ION, NITRATE ION, SODIUM ION, ... | 著者 | Deng, L, Langley, R.J, Wang, Q, Topalian, S.L, Mariuzza, R.A. | 登録日 | 2012-03-11 | 公開日 | 2012-08-29 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4 Proc.Natl.Acad.Sci.USA, 2012
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4E41
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![BU of 4e41 by Molmil](/molmil-images/mine/4e41) | Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4 | 分子名称: | HLA class II histocompatibility antigen, DR alpha chain, DRB1-1 beta chain, ... | 著者 | Deng, L, Langley, R.J, Wang, Q, Topalian, S.L, Mariuzza, R.A. | 登録日 | 2012-03-11 | 公開日 | 2012-08-29 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4 Proc.Natl.Acad.Sci.USA, 2012
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2KDF
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![BU of 2kdf by Molmil](/molmil-images/mine/2kdf) | NMR structure of minor S5a (196-306):K48 linked diubiquitin species | 分子名称: | 26S proteasome non-ATPase regulatory subunit 4, Ubiquitin | 著者 | Zhang, N, Wang, Q, Ehlinger, A, Randles, L, Lary, J.W, Kang, Y, Haririnia, A, Cole, J.L, Fushman, D, Walters, K.J. | 登録日 | 2009-01-06 | 公開日 | 2009-09-01 | 最終更新日 | 2022-03-16 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of the s5a:k48-linked diubiquitin complex and its interactions with rpn13. Mol.Cell, 35, 2009
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5WT9
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![BU of 5wt9 by Molmil](/molmil-images/mine/5wt9) | Complex structure of PD-1 and nivolumab-Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain of Nivolumab, Light Chain of Nivolumab, ... | 著者 | Tan, S, Zhang, H, Chai, Y, Song, H, Tong, Z, Wang, Q, Qi, J, Wong, G, Zhu, X, Liu, W.J, Gao, S, Wang, Z, Shi, Y, Yang, F, Gao, G.F, Yan, J. | 登録日 | 2016-12-10 | 公開日 | 2017-02-15 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | 主引用文献 | An unexpected N-terminal loop in PD-1 dominates binding by nivolumab. Nat Commun, 8, 2017
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6M71
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![BU of 6m71 by Molmil](/molmil-images/mine/6m71) | SARS-Cov-2 RNA-dependent RNA polymerase in complex with cofactors | 分子名称: | Non-structural protein 7, Non-structural protein 8, RNA-directed RNA polymerase | 著者 | Gao, Y, Yan, L, Huang, Y, Liu, F, Cao, L, Wang, T, Wang, Q, Lou, Z, Rao, Z. | 登録日 | 2020-03-16 | 公開日 | 2020-04-01 | 最終更新日 | 2021-03-10 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Science, 368, 2020
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3ULX
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2KDE
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![BU of 2kde by Molmil](/molmil-images/mine/2kde) | NMR structure of major S5a (196-306):K48 linked diubiquitin species | 分子名称: | 26S proteasome non-ATPase regulatory subunit 4, Ubiquitin | 著者 | Zhang, N, Wang, Q, Ehlinger, A, Randles, L, Lary, J.W, Kang, Y, Haririnia, A, Cole, J.L, Fushman, D, Walters, K.J. | 登録日 | 2009-01-06 | 公開日 | 2009-09-01 | 最終更新日 | 2022-03-16 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of the s5a:k48-linked diubiquitin complex and its interactions with rpn13. Mol.Cell, 35, 2009
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4NRJ
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![BU of 4nrj by Molmil](/molmil-images/mine/4nrj) | Structure of hemagglutinin with F95Y mutation of influenza virus B/Lee/40 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HEMAGGLUTININ HA1 CHAIN, ... | 著者 | Ni, F, Mbawuike, I.N, Kondrashkina, E, Wang, Q. | 登録日 | 2013-11-26 | 公開日 | 2014-03-12 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | The roles of hemagglutinin Phe-95 in receptor binding and pathogenicity of influenza B virus. Virology, 450-451, 2014
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