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1NP0
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Human lysosomal beta-hexosaminidase isoform B in complex with intermediate analogue NAG-thiazoline
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL, Beta-hexosaminidase subunit beta, ...
著者Mark, B.L, Mahuran, D.J, Cherney, M.M, Zhao, D, Knapp, S, James, M.N.G.
登録日2003-01-16
公開日2003-04-29
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of Human beta-hexosaminidase B: Understanding the molecular basis of Sandhoff and Tay-Sachs disease
J.Mol.Biol., 327, 2003
1NOW
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BU of 1now by Molmil
Human lysosomal beta-hexosaminidase isoform B in complex with (2R,3R,4S,5R)-2-Acetamido-3,4-Dihydroxy-5-Hydroxymethyl-Piperidinium Chloride (GalNAc-isofagomine)
分子名称: (2R,3R,4S,5R)-2-ACETAMIDO-3,4-DIHYDROXY-5-HYDROXYMETHYL-PIPERIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
著者Mark, B.L, Mahuran, D.J, Cherney, M.M, Zhao, D, Knapp, S, James, M.N.G.
登録日2003-01-16
公開日2003-04-29
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of Human beta-hexosaminidase B: Understanding the molecular basis of Sandhoff and Tay-Sachs disease
J.Mol.Biol., 327, 2003
1NOU
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BU of 1nou by Molmil
Native human lysosomal beta-hexosaminidase isoform B
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, SULFATE ION, ...
著者Mark, B.L, Mahuran, D.J, Cherney, M.M, Zhao, D, Knapp, S, James, M.N.G.
登録日2003-01-16
公開日2003-04-08
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of Human beta-hexosaminidase B: Understanding the molecular basis of Sandhoff and Tay-Sachs disease
J.Mol.Biol., 327, 2003
1R4P
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BU of 1r4p by Molmil
Shiga toxin type 2
分子名称: 1,2-ETHANEDIOL, 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, FORMIC ACID, ...
著者Fraser, M.E, Fujinaga, M, Cherney, M.M, Melton-Celsa, A.R, Twiddy, E.M, O'Brien, A.D, James, M.N.G.
登録日2003-10-07
公開日2004-05-11
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Structure of Shiga Toxin Type 2 (Stx2) from Escherichia coli O157:H7.
J.Biol.Chem., 279, 2004
1R4Q
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BU of 1r4q by Molmil
Shiga toxin
分子名称: SHT cytotoxin A subunit, Shigella toxin chain B
著者Fraser, M.E, Fujinaga, M, Cherney, M.M, Melton-Celsa, A.R, Twiddy, E.M, O'Brien, A.D, James, M.N.G.
登録日2003-10-07
公開日2004-05-11
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of Shiga Toxin Type 2 (Stx2) from Escherichia coli O157:H7.
J.Biol.Chem., 279, 2004
2ULL
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BU of 2ull by Molmil
MULTIPLE CONFORMATION STRUCTURE OF ALPHA-LYTIC PROTEASE AT 120 K
分子名称: ALPHA-LYTIC PROTEASE, SULFATE ION, TRIS(HYDROXYETHYL)AMINOMETHANE
著者Rader, S.D, Agard, D.A.
登録日1996-11-26
公開日1997-07-07
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Conformational substates in enzyme mechanism: the 120 K structure of alpha-lytic protease at 1.5 A resolution.
Protein Sci., 6, 1997
5BWY
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BU of 5bwy by Molmil
Structure of proplasmepsin II from Plasmodium falciparum, Space Group P43212
分子名称: Plasmepsin-2
著者Recacha, R, Akopjana, I, Tars, K, Jaudzems, K.
登録日2015-06-08
公開日2015-12-16
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.644 Å)
主引用文献Crystal structure of Plasmodium falciparum proplasmepsin IV: the plasticity of proplasmepsins.
Acta Crystallogr F Struct Biol Commun, 72, 2016
1HP4
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BU of 1hp4 by Molmil
CRYSTAL STRUCTURE OF STREPTOMYCES PLICATUS BETA-N-ACETYLHEXOSAMINIDASE
分子名称: BETA-N-ACETYLHEXOSAMINIDASE, CHLORIDE ION, GLYCEROL, ...
著者Mark, B.L.
登録日2000-12-12
公開日2001-04-04
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase.
J.Biol.Chem., 276, 2001
5JOD
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BU of 5jod by Molmil
Structure of proplasmepsin IV from Plasmodium falciparum
分子名称: GLYCEROL, Proplasmepsin IV
著者Recacha, R, Akopjana, I, Tars, K, Jaudzems, K.
登録日2016-05-02
公開日2016-08-17
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.528 Å)
主引用文献Crystal structure of Plasmodium falciparum proplasmepsin IV: the plasticity of proplasmepsins.
Acta Crystallogr.,Sect.F, 72, 2016
4Z22
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BU of 4z22 by Molmil
structure of plasmepsin II from Plasmodium Falciparum complexed with inhibitor DR718A
分子名称: 2-amino-7-phenyl-3-{[(2R,5S)-5-phenyltetrahydrofuran-2-yl]methyl}quinazolin-4(3H)-one, Plasmepsin-2
著者Recacha, R, Leitans, J, Tars, K, Jaudzems, K.
登録日2015-03-28
公開日2016-01-13
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.62 Å)
主引用文献Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV.
J.Med.Chem., 59, 2016
4YA8
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BU of 4ya8 by Molmil
structure of plasmepsin II from Plasmodium Falciparum complexed with inhibitor PG394
分子名称: GLYCEROL, N'-[(2S,3S)-3-hydroxy-1-phenyl-4-{[2-(pyridin-2-yl)propan-2-yl]amino}butan-2-yl]-N,N-dipropyl-5-(pyridin-1(2H)-yl)benzene-1,3-dicarboxamide, Plasmepsin-2
著者Recacha, R, Leitans, J, Tars, K, Jaudzems, K.
登録日2015-02-17
公開日2015-12-09
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.301 Å)
主引用文献Structures of plasmepsin II from Plasmodium falciparum in complex with two hydroxyethylamine-based inhibitors.
Acta Crystallogr.,Sect.F, 71, 2015
4PEP
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BU of 4pep by Molmil
THE MOLECULAR AND CRYSTAL STRUCTURES OF MONOCLINIC PORCINE PEPSIN REFINED AT 1.8 ANGSTROMS RESOLUTION
分子名称: PEPSIN
著者Andreeva, N, Fedorov, A.A, Sielecki, A, James, M.
登録日1989-12-18
公開日1990-04-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Molecular and crystal structures of monoclinic porcine pepsin refined at 1.8 A resolution.
J.Mol.Biol., 214, 1990
4SGB
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BU of 4sgb by Molmil
STRUCTURE OF THE COMPLEX OF STREPTOMYCES GRISEUS PROTEINASE B AND POLYPEPTIDE CHYMOTRYPSIN INHIBITOR-1 FROM RUSSET BURBANK POTATO TUBERS AT 2.1 ANGSTROMS RESOLUTION
分子名称: CALCIUM ION, POTATO INHIBITOR, PCI-1, ...
著者James, M, Greenblatt, H.
登録日1989-09-21
公開日1990-07-15
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of the complex of Streptomyces griseus proteinase B and polypeptide chymotrypsin inhibitor-1 from Russet Burbank potato tubers at 2.1 A resolution.
J.Mol.Biol., 205, 1989
1TAL
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BU of 1tal by Molmil
ALPHA-LYTIC PROTEASE AT 120 K (SINGLE STRUCTURE MODEL)
分子名称: ALPHA-LYTIC PROTEASE, SULFATE ION, TRIS(HYDROXYETHYL)AMINOMETHANE
著者Rader, S.D, Agard, D.A.
登録日1996-10-30
公開日1997-04-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Conformational substates in enzyme mechanism: the 120 K structure of alpha-lytic protease at 1.5 A resolution.
Protein Sci., 6, 1997
1BOQ
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BU of 1boq by Molmil
PRO REGION C-TERMINUS: PROTEASE ACTIVE SITE INTERACTIONS ARE CRITICAL IN CATALYZING THE FOLDING OF ALPHA-LYTIC PROTEASE
分子名称: PROTEIN (ALPHA-LYTIC PROTEASE), SULFATE ION
著者Peters, R.J, Shiau, A.K, Sohl, J.L, Anderson, D.E, Tang, G, Silen, J.L, Agard, D.A.
登録日1998-08-05
公開日1998-08-12
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Pro region C-terminus:protease active site interactions are critical in catalyzing the folding of alpha-lytic protease.
Biochemistry, 37, 1998
1HP5
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BU of 1hp5 by Molmil
STREPTOMYCES PLICATUS BETA-N-ACETYLHEXOSAMINIDASE COMPLEXED WITH INTERMEDIATE ANALOUGE NAG-THIAZOLINE
分子名称: 3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL, BETA-N-ACETYLHEXOSAMINIDASE, CHLORIDE ION, ...
著者Mark, B.L.
登録日2000-12-12
公開日2001-04-04
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase.
J.Biol.Chem., 276, 2001
2Z3C
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BU of 2z3c by Molmil
A Mechanistic view of Enzyme Inhibition and Peptide Hydrolysis in the Active Site of the SARS-CoV 3C-Like peptidase
分子名称: GLYCEROL, Replicase polyprotein 1ab (pp1ab), inhibitor
著者Yin, J.
登録日2007-06-04
公開日2007-07-03
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献A mechanistic view of enzyme inhibition and peptide hydrolysis in the active site of the SARS-CoV 3C-like peptidase
J.Mol.Biol., 371, 2007
2Z3D
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BU of 2z3d by Molmil
A Mechanistic view of Enzyme Inhibition and Peptide Hydrolysis in the Active Site of the SARS-CoV 3C-Like peptidase
分子名称: GLYCEROL, Inhibitor, Replicase polyprotein 1ab (pp1ab)
著者Yin, J.
登録日2007-06-04
公開日2007-07-03
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A mechanistic view of enzyme inhibition and peptide hydrolysis in the active site of the SARS-CoV 3C-like peptidase
J.Mol.Biol., 371, 2007
2Z3E
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A Mechanistic view of Enzyme Inhibition and Peptide Hydrolysis in the Active Site of the SARS-CoV 3C-Like peptidase
分子名称: ACE VAL Z3E LEU KCQ peptide, GLYCEROL, Replicase polyprotein 1ab (pp1ab)
著者Yin, J.
登録日2007-06-04
公開日2007-07-03
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献A mechanistic view of enzyme inhibition and peptide hydrolysis in the active site of the SARS-CoV 3C-like peptidase
J.Mol.Biol., 371, 2007
2ZJF
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BU of 2zjf by Molmil
Crystal structure of Mycobacterium tuberculosis epoxide hydrolase B complexed with an inhibitor
分子名称: 1,3-DIPHENYLUREA, ACETATE ION, Probable epoxide hydrolase ephB
著者Biswal, B.K, TB Structural Genomics Consortium (TBSGC)
登録日2008-03-07
公開日2008-04-01
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitor.
J.Mol.Biol., 381, 2008
3LPR
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BU of 3lpr by Molmil
STRUCTURAL BASIS FOR BROAD SPECIFICITY IN ALPHA-LYTIC PROTEASE MUTANTS
分子名称: ALPHA-LYTIC PROTEASE, METHOXYSUCCINYL-ALA-ALA-PRO-NORLEUCINE BORONIC ACID INHIBITOR, SULFATE ION
著者Bone, R, Agard, D.A.
登録日1991-08-05
公開日1993-01-15
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural basis for broad specificity in alpha-lytic protease mutants.
Biochemistry, 30, 1991
2E3J
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BU of 2e3j by Molmil
The crystal structure of epoxide hydrolase B (Rv1938) from mycobacterium tuberculosis at 2.1 angstrom
分子名称: ACETATE ION, EPOXIDE HYDROLASE EPHB
著者Biswal, B.K, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
登録日2006-11-27
公開日2007-12-04
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitor.
J.Mol.Biol., 381, 2008
2GA4
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Stx2 with adenine
分子名称: 1,2-ETHANEDIOL, 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, ADENINE, ...
著者Fraser, M.E.
登録日2006-03-07
公開日2006-07-11
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Binding of adenine to Stx2, the protein toxin from Escherichia coli O157:H7.
Acta Crystallogr.,Sect.F, 62, 2006
1FQG
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MOLECULAR STRUCTURE OF THE ACYL-ENZYME INTERMEDIATE IN TEM-1 BETA-LACTAMASE
分子名称: OPEN FORM - PENICILLIN G, TEM-1 BETA-LACTAMASE
著者Strynadka, N.C.
登録日2000-09-05
公開日2000-11-01
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Molecular structure of the acyl-enzyme intermediate in beta-lactam hydrolysis at 1.7 A resolution.
Nature, 359, 1992
1HI3
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Eosinophil-derived Neurotoxin (EDN) - Adenosine 2'-5'-Diphosphate Complex
分子名称: ADENOSINE-2'-5'-DIPHOSPHATE, EOSINOPHIL-DERIVED NEUROTOXIN
著者Leonidas, D.D, Boix, E, Prill, R, Suzuki, M, Turton, R, Minson, K, Swaminathan, G.J, Youle, R.J, Acharya, K.R.
登録日2001-01-02
公開日2001-05-31
最終更新日2018-05-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Mapping the Ribonucleolytic Active Site of Eosinophil-Derived Neurotoxin (Edn): High Resolution Crystal Structures of Edn Complexes with Adenylic Nucleotide Inhibitors
J.Biol.Chem., 276, 2001

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