5BWY

Structure of proplasmepsin II from Plasmodium falciparum, Space Group P43212

Summary for 5BWY

• Entry DOI: 10.2210/pdb5bwy/pdb
• Descriptor: Plasmepsin-2 (2 entities in total)
• Functional Keywords: malaria, hydrolase
• Biological source: Plasmodium falciparum
• Total number of polymer chains: 1
• Total formula weight: 42374.97

Authors

Recacha, R.,Akopjana, I.,Tars, K.,Jaudzems, K. (deposition date: 2015-06-08, release date: 2015-12-16, Last modification date: 2024-11-06)

Primary citation

Recacha, R.,Jaudzems, K.,Akopjana, I.,Jirgensons, A.,Tars, K.
Crystal structure of Plasmodium falciparum proplasmepsin IV: the plasticity of proplasmepsins.
Acta Crystallogr F Struct Biol Commun, 72:659-666, 2016

PubMed Abstract: Plasmepsin IV from Plasmodium falciparum (PM IV) is a promising target for the development of novel antimalarial drugs. Here, the crystal structure of the truncated zymogen of PM IV (pPM IV), consisting of the mature enzyme plus a prosegment of 47 residues, has been determined at 1.5 Å resolution. pPM IV presents the fold previously described for studied proplasmepsins, displaying closer similarities to proplasmepin IV from P. vivax (pPvPM) than to the other two proplasmepsins from P. falciparum. The study and comparison of the pPM IV structure with the proplasmepsin structures described previously provide information about the similarities and differences in the inactivation-activation mechanisms among the plasmepsin zymogens.

PubMed: 27599854
DOI: 10.1107/S2053230X16011663

Experimental method

X-RAY DIFFRACTION (2.644 Å)