Summary for 5JOD
| Entry DOI | 10.2210/pdb5jod/pdb |
| Related | 4y7h |
| Descriptor | Proplasmepsin IV, GLYCEROL (3 entities in total) |
| Functional Keywords | malaria, hydrolase |
| Biological source | Plasmodium falciparum (malaria parasite P. falciparum) |
| Total number of polymer chains | 2 |
| Total formula weight | 85574.24 |
| Authors | Recacha, R.,Akopjana, I.,Tars, K.,Jaudzems, K. (deposition date: 2016-05-02, release date: 2016-08-17, Last modification date: 2024-01-10) |
| Primary citation | Recacha, R.,Jaudzems, K.,Akopjana, I.,Jirgensons, A.,Tars, K. Crystal structure of Plasmodium falciparum proplasmepsin IV: the plasticity of proplasmepsins. Acta Crystallogr.,Sect.F, 72:659-666, 2016 Cited by PubMed Abstract: Plasmepsin IV from Plasmodium falciparum (PM IV) is a promising target for the development of novel antimalarial drugs. Here, the crystal structure of the truncated zymogen of PM IV (pPM IV), consisting of the mature enzyme plus a prosegment of 47 residues, has been determined at 1.5 Å resolution. pPM IV presents the fold previously described for studied proplasmepsins, displaying closer similarities to proplasmepin IV from P. vivax (pPvPM) than to the other two proplasmepsins from P. falciparum. The study and comparison of the pPM IV structure with the proplasmepsin structures described previously provide information about the similarities and differences in the inactivation-activation mechanisms among the plasmepsin zymogens. PubMed: 27599854DOI: 10.1107/S2053230X16011663 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.528 Å) |
Structure validation
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