4YA8
structure of plasmepsin II from Plasmodium Falciparum complexed with inhibitor PG394
Summary for 4YA8
Entry DOI | 10.2210/pdb4ya8/pdb |
Descriptor | Plasmepsin-2, N'-[(2S,3S)-3-hydroxy-1-phenyl-4-{[2-(pyridin-2-yl)propan-2-yl]amino}butan-2-yl]-N,N-dipropyl-5-(pyridin-1(2H)-yl)benzene-1,3-dicarboxamide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | plasmepsin ii, malaria, inhibitor, hydrolase |
Biological source | Plasmodium falciparum |
Cellular location | Vacuole: P46925 |
Total number of polymer chains | 4 |
Total formula weight | 150353.95 |
Authors | Recacha, R.,Leitans, J.,Tars, K.,Jaudzems, K. (deposition date: 2015-02-17, release date: 2015-12-09, Last modification date: 2024-01-10) |
Primary citation | Recacha, R.,Leitans, J.,Akopjana, I.,Aprupe, L.,Trapencieris, P.,Jaudzems, K.,Jirgensons, A.,Tars, K. Structures of plasmepsin II from Plasmodium falciparum in complex with two hydroxyethylamine-based inhibitors. Acta Crystallogr.,Sect.F, 71:1531-1539, 2015 Cited by PubMed: 26625296DOI: 10.1107/S2053230X15022049 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.301 Å) |
Structure validation
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