4YA8

structure of plasmepsin II from Plasmodium Falciparum complexed with inhibitor PG394

Summary for 4YA8

Entry DOI	10.2210/pdb4ya8/pdb
Descriptor	Plasmepsin-2, N'-[(2S,3S)-3-hydroxy-1-phenyl-4-{[2-(pyridin-2-yl)propan-2-yl]amino}butan-2-yl]-N,N-dipropyl-5-(pyridin-1(2H)-yl)benzene-1,3-dicarboxamide, GLYCEROL, ... (4 entities in total)
Functional Keywords	plasmepsin ii, malaria, inhibitor, hydrolase
Biological source	Plasmodium falciparum
Cellular location	Vacuole: P46925
Total number of polymer chains	4
Total formula weight	150353.95
Authors	Recacha, R.,Leitans, J.,Tars, K.,Jaudzems, K. (deposition date: 2015-02-17, release date: 2015-12-09, Last modification date: 2024-01-10)
Primary citation	Recacha, R.,Leitans, J.,Akopjana, I.,Aprupe, L.,Trapencieris, P.,Jaudzems, K.,Jirgensons, A.,Tars, K. Structures of plasmepsin II from Plasmodium falciparum in complex with two hydroxyethylamine-based inhibitors. Acta Crystallogr.,Sect.F, 71:1531-1539, 2015 Cited by PubMed: 26625296 DOI: 10.1107/S2053230X15022049 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.301 Å)

Structure validation