4YA8
structure of plasmepsin II from Plasmodium Falciparum complexed with inhibitor PG394
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Plasmepsin-2 | polymer | 329 | 36909.6 | 4 | UniProt (P46925) Pfam (PF00026) | Plasmodium falciparum | Aspartic hemoglobinase II,PFAPD |
| 2 | E, F, H, K (A, B, C, D) | N'-[(2S,3S)-3-hydroxy-1-phenyl-4-{[2-(pyridin-2-yl)propan-2-yl]amino}butan-2-yl]-N,N-dipropyl-5-(pyridin-1(2H)-yl)benzene-1,3-dicarboxamide | non-polymer | 609.8 | 4 | Chemie (49W) | |||
| 3 | G, I, J (B, C) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 4 | L, M (A, B) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 329 (UniProt: P46925)
| PDB | External Database | Details |
|---|---|---|
| Ser 205 | Met 329 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 147638.5 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2715.5 | |
| All* | Total formula weight | 150354.0 |
