5KW1
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![BU of 5kw1 by Molmil](/molmil-images/mine/5kw1) | Crystal Structure of the Two Tandem RRM Domains of PUF60 Bound to a Modified AdML Pre-mRNA 3' Splice Site Analogue | Descriptor: | CHLORIDE ION, DNA/RNA (30-MER), Poly(U)-binding-splicing factor PUF60 | Authors: | Crichlow, G.V, Hsiao, H.-H, Albright, R, Lolis, E.J, Braddock, D.T. | Deposit date: | 2016-07-15 | Release date: | 2017-08-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60. Plos One, 15, 2020
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5KVY
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![BU of 5kvy by Molmil](/molmil-images/mine/5kvy) | CRYSTAL STRUCTURE OF THE TWO TANDEM RRM DOMAINS OF PUF60 BOUND TO A PORTION OF AN ADML PRE-MRNA 3' SPLICE SITE ANALOG | Descriptor: | CHLORIDE ION, DNA (30-MER), Poly(U)-binding-splicing factor PUF60 | Authors: | Hsiao, H.-H, Crichlow, G.V, Albright, R.A, Murphy, J.W, Lolis, E.J, Braddock, D.T. | Deposit date: | 2016-07-15 | Release date: | 2017-08-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60. Plos One, 15, 2020
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5KWQ
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![BU of 5kwq by Molmil](/molmil-images/mine/5kwq) | Two Tandem RRM Domains of FBP-Interacting Repressor (FIR), also Known as PUF60 | Descriptor: | Poly(U)-binding-splicing factor PUF60 | Authors: | Crichlow, G.V, Yang, Y, Zhou, H, Lolis, E.J, Braddock, D.T. | Deposit date: | 2016-07-18 | Release date: | 2017-08-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60. Plos One, 15, 2020
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5KW6
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![BU of 5kw6 by Molmil](/molmil-images/mine/5kw6) | Two Tandem RRM Domains of PUF60 Bound to an AdML Pre-mRNA 3' Splice Site Analogue with a Modified Binding-Site Nucleic Acid Base | Descriptor: | DNA (30-MER), Poly(U)-binding-splicing factor PUF60 | Authors: | Crichlow, G.V, Hsiao, H.-H, Albright, R, Lolis, E.J, Braddock, D.T. | Deposit date: | 2016-07-15 | Release date: | 2017-08-23 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60. Plos One, 15, 2020
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6VGJ
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![BU of 6vgj by Molmil](/molmil-images/mine/6vgj) | N-terminal variant of CXCL13 | Descriptor: | C-X-C motif chemokine 13 | Authors: | Rosenberg Jr, E.M, Lolis, E.J. | Deposit date: | 2020-01-08 | Release date: | 2020-10-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | The N-terminal length and side-chain composition of CXCL13 affect crystallization, structure and functional activity. Acta Crystallogr D Struct Biol, 76, 2020
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3SMC
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![BU of 3smc by Molmil](/molmil-images/mine/3smc) | |
3SMB
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![BU of 3smb by Molmil](/molmil-images/mine/3smb) | |
6C5F
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![BU of 6c5f by Molmil](/molmil-images/mine/6c5f) | |
3IJG
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![BU of 3ijg by Molmil](/molmil-images/mine/3ijg) | Macrophage Migration Inhibitory Factor (MIF) Bound to the (R)-Stereoisomer of AV1013 | Descriptor: | (2R)-2-amino-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one, CHLORIDE ION, Macrophage migration inhibitory factor | Authors: | Crichlow, G.V, Cho, Y, Lolis, E.J. | Deposit date: | 2009-08-04 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proc.Natl.Acad.Sci.USA, 107, 2010
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3IJJ
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![BU of 3ijj by Molmil](/molmil-images/mine/3ijj) | Ternary Complex of Macrophage Migration Inhibitory Factor (MIF) Bound Both to 4-hydroxyphenylpyruvate and to the Allosteric Inhibitor AV1013 (R-stereoisomer) | Descriptor: | (2E)-2-hydroxy-3-(4-hydroxyphenyl)prop-2-enoic acid, (2R)-2-amino-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one, 3-(4-HYDROXY-PHENYL)PYRUVIC ACID, ... | Authors: | Crichlow, G.V, Cho, Y, Lolis, E.J. | Deposit date: | 2009-08-04 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proc.Natl.Acad.Sci.USA, 107, 2010
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3MZG
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![BU of 3mzg by Molmil](/molmil-images/mine/3mzg) | Crystal structure of a human prolactin receptor antagonist in complex with the extracellular domain of the human prolactin receptor | Descriptor: | CHLORIDE ION, Prolactin, Prolactin receptor, ... | Authors: | Kulkarni, M.V, Tettamanzi, M.C, Murphy, J.W, Keeler, C, Myszka, D.G, Chayen, N.E, Lolis, E.J, Hodsdon, M.E. | Deposit date: | 2010-05-12 | Release date: | 2010-09-29 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation. J.Biol.Chem., 285, 2010
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3N06
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![BU of 3n06 by Molmil](/molmil-images/mine/3n06) | A mutant human Prolactin receptor antagonist H27A in complex with the extracellular domain of the human prolactin receptor | Descriptor: | CHLORIDE ION, Prolactin, Prolactin receptor, ... | Authors: | Kulkarni, M.V, Tettamanzi, M.C, Murphy, J.W, Keeler, C, Myszka, D.G, Chayen, N.E, Lolis, E.J, Hodsdon, M.E. | Deposit date: | 2010-05-13 | Release date: | 2010-09-29 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation. J.Biol.Chem., 285, 2010
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3NCE
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![BU of 3nce by Molmil](/molmil-images/mine/3nce) | A mutant human Prolactin receptor antagonist H27A in complex with the mutant extracellular domain H188A of the human prolactin receptor | Descriptor: | CARBONATE ION, CHLORIDE ION, Prolactin, ... | Authors: | Kulkarni, M.V, Tettamanzi, M.C, Murphy, J.W, Keeler, C, Myszka, D.G, Chayen, N.E, Lolis, E.J, Hodsdon, M.E. | Deposit date: | 2010-06-04 | Release date: | 2010-09-29 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation. J.Biol.Chem., 285, 2010
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3N0P
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![BU of 3n0p by Molmil](/molmil-images/mine/3n0p) | A mutant human Prolactin receptor antagonist H30A in complex with the extracellular domain of the human prolactin receptor | Descriptor: | CHLORIDE ION, Prolactin, Prolactin receptor, ... | Authors: | Kulkarni, M.V, Tettamanzi, M.C, Murphy, J.W, Keeler, C, Myszka, D.G, Chayen, N.E, Lolis, E.J, Hodsdon, M.E. | Deposit date: | 2010-05-14 | Release date: | 2010-09-29 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation. J.Biol.Chem., 285, 2010
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3NCB
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![BU of 3ncb by Molmil](/molmil-images/mine/3ncb) | A mutant human Prolactin receptor antagonist H180A in complex with the extracellular domain of the human prolactin receptor | Descriptor: | CARBONATE ION, CHLORIDE ION, Prolactin, ... | Authors: | Kulkarni, M.V, Tettamanzi, M.C, Murphy, J.W, Keeler, C, Myszka, D.G, Chayen, N.E, Lolis, E.J, Hodsdon, M.E. | Deposit date: | 2010-06-04 | Release date: | 2010-09-29 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation. J.Biol.Chem., 285, 2010
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3NCF
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![BU of 3ncf by Molmil](/molmil-images/mine/3ncf) | A mutant human Prolactin receptor antagonist H30A in complex with the mutant extracellular domain H188A of the human prolactin receptor | Descriptor: | CHLORIDE ION, Prolactin, Prolactin receptor, ... | Authors: | Kulkarni, M.V, Tettamanzi, M.C, Murphy, J.W, Keeler, C, Myszka, D.G, Chayen, N.E, Lolis, E.J, Hodsdon, M.E. | Deposit date: | 2010-06-04 | Release date: | 2010-09-29 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation. J.Biol.Chem., 285, 2010
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3NCC
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![BU of 3ncc by Molmil](/molmil-images/mine/3ncc) | A human Prolactin receptor antagonist in complex with the mutant extracellular domain H188A of the human prolactin receptor | Descriptor: | CARBONATE ION, CHLORIDE ION, Prolactin, ... | Authors: | Kulkarni, M.V, Tettamanzi, M.C, Murphy, J.W, Keeler, C, Myszka, D.G, Chayen, N.E, Lolis, E.J, Hodsdon, M.E. | Deposit date: | 2010-06-04 | Release date: | 2010-09-29 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation. J.Biol.Chem., 285, 2010
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4HCS
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![BU of 4hcs by Molmil](/molmil-images/mine/4hcs) | Structure of Novel subfamily CX chemokine solved by sulfur SAD | Descriptor: | Uncharacterized protein | Authors: | Rajasekaran, D, Fan, C, Meng, W, Pflugrath, J.W, Lolis, E.J. | Deposit date: | 2012-10-01 | Release date: | 2013-10-16 | Last modified: | 2014-04-23 | Method: | X-RAY DIFFRACTION (1.28 Å) | Cite: | Structural insight into the evolution of a new chemokine family from zebrafish. Proteins, 82, 2014
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4HED
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![BU of 4hed by Molmil](/molmil-images/mine/4hed) | Zebrafish chemokine CXL1 | Descriptor: | Uncharacterized protein | Authors: | Rajasekaran, D, Fan, C, Meng, W, Pflugrath, J.W, Lolis, E.J. | Deposit date: | 2012-10-03 | Release date: | 2013-08-21 | Last modified: | 2014-04-23 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Structural insight into the evolution of a new chemokine family from zebrafish. Proteins, 82, 2014
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4K9G
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![BU of 4k9g by Molmil](/molmil-images/mine/4k9g) | 1.55 A Crystal Structure of Macrophage Migration Inhibitory Factor bound to ISO-66 and a related compound | Descriptor: | (4R,6Z)-6-(3-fluoro-4-hydroxyphenyl)-4-hydroxy-6-iminohexan-2-one, 1-[(5S)-3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]propan-2-one, CHLORIDE ION, ... | Authors: | Crichlow, G.V, Al-Abed, Y, Lolis, E.J. | Deposit date: | 2013-04-19 | Release date: | 2014-09-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | ISO-66, a novel inhibitor of macrophage migration, shows efficacy in melanoma and colon cancer models. INT J ONCOL., 45, 2014
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7KQX
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![BU of 7kqx by Molmil](/molmil-images/mine/7kqx) | MIF Y99C homotrimeric mutant | Descriptor: | GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... | Authors: | Manjula, R, Georgios, P, Lolis, E.J. | Deposit date: | 2020-11-18 | Release date: | 2022-01-19 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | A Cysteine Variant at an Allosteric Site Alters MIF Dynamics and Biological Function in Homo- and Heterotrimeric Assemblies. Front Mol Biosci, 9, 2022
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7JNY
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![BU of 7jny by Molmil](/molmil-images/mine/7jny) | Crystal structure of CXCL13 | Descriptor: | C-X-C motif chemokine 13 | Authors: | Rosenberg Jr, E.M, Rajasekaran, D, Murphy, J.W, Pantouris, G, Lolis, E.J. | Deposit date: | 2020-08-05 | Release date: | 2020-10-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | The N-terminal length and side-chain composition of CXCL13 affect crystallization, structure and functional activity. Acta Crystallogr D Struct Biol, 76, 2020
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5BS9
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![BU of 5bs9 by Molmil](/molmil-images/mine/5bs9) | |
6OYB
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![BU of 6oyb by Molmil](/molmil-images/mine/6oyb) | |
6OYE
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![BU of 6oye by Molmil](/molmil-images/mine/6oye) | |